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Purification of Borrelia burgdorferi Outer Membrane Vesicles
Bacterial outer membrane vesicles (OMVs) are spherical membrane constructs shed by gram-negative bacteria. OMVs produced by the Lyme disease pathogen...
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SlyB encapsulates outer membrane proteins in stress-induced lipid nanodomains
The outer membrane in Gram-negative bacteria consists of an asymmetric phospholipid—lipopolysaccharide bilayer that is densely packed with...
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Maintenance of bacterial outer membrane lipid asymmetry: insight into MlaA
The outer membrane (OM) of Gram-negative bacteria acts as an effective barrier to protect against toxic compounds. By nature, the OM is asymmetric...
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Molecular mechanism of phospholipid transport at the bacterial outer membrane interface
The outer membrane (OM) of Gram-negative bacteria is an asymmetric lipid bilayer with outer leaflet lipopolysaccharides and inner leaflet...
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Mechanism of outer membrane destabilization by global reduction of protein content
The outer membrane (OM) of Gram-negative bacteria such as Escherichia coli is an asymmetric bilayer with the glycolipid lipopolysaccharide (LPS) in...
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Preparation of Protein-Enriched Outer Membrane Vesicles from Escherichia Coli for In Situ Structural Biology of Outer Membrane Proteins
Bacterial outer membrane vesicles (OMVs) can be selectively enriched with one or more outer membrane proteins to allow the biophysical...
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Tackling the outer membrane: facilitating compound entry into Gram-negative bacterial pathogens
Emerging resistance to all available antibiotics highlights the need to develop new antibiotics with novel mechanisms of action. Most of the...
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Structural Modeling of T9SS Outer Membrane Proteins and Their Complexes
The type 9 secretion system (T9SS) is a recently discovered machinery that both transports cargo proteins across the Gram-negative bacterial outer...
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Outer Membrane Vesicle Vaccine Platforms
Outer membrane vesicles (OMVs) are spontaneously released by many gram-negative bacteria during their growth and constitute an important virulence...
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Outer membrane vesicles as a platform for the discovery of antibodies to bacterial pathogens
AbstractBacterial outer membrane vesicles (OMVs) are nanosized spheroidal particles shed by gram-negative bacteria that contain biomolecules derived...
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Protein–lipid charge interactions control the folding of outer membrane proteins into asymmetric membranes
Biological membranes consist of two leaflets of phospholipid molecules that form a bilayer, each leaflet comprising a distinct lipid composition....
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Outer membrane utilisomes mediate glycan uptake in gut Bacteroidetes
Bacteroidetes are abundant members of the human microbiota, utilizing a myriad of diet- and host-derived glycans in the distal gut
1 . Glycan uptake...
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Targeting Outer Membrane to Tackle Multidrug-Resistant Bacterial Pathogens
Infections caused due to Gram-negative bacterial pathogens, under community as well as nosocomial settings, are increasing affecting healthcare...
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Bacterial outer membrane vesicle-cancer cell hybrid membrane-coated nanoparticles for sonodynamic therapy in the treatment of breast cancer bone metastasis
Breast cancer bone metastasis is a terminal-stage disease and is typically treated with radiotherapy and chemotherapy, which causes severe side...
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Pore-Forming VDAC Proteins of the Outer Mitochondrial Membrane: Regulation and Pathophysiological Role
AbstractVoltage-dependent anion channels (VDAC1-3) of the outer mitochondrial membrane are a family of pore-forming β-barrel proteins that carry out...
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Molecular imaging of bacterial outer membrane vesicles based on bacterial surface display
The important roles of bacterial outer membrane vesicles (OMVs) in various diseases and their emergence as a promising platform for vaccine...
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Peptidoglycan maturation controls outer membrane protein assembly
Linkages between the outer membrane of Gram-negative bacteria and the peptidoglycan layer are crucial for the maintenance of cellular integrity and...
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Proteomic and Functional Analyses of Outer Membrane Vesicles Secreted by Vibrio splendidus
Vibrio splendidus is an important opportunistic pathogen ubiquitously present in the marine environment, exhibiting virulence to a variety of...
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Fluorescent Labeling of Outer Membrane Proteins Using the SpyCatcher-SpyTag System
The SpyCatcher-SpyTag system has become a popular and versatile tool for protein ligation. It is based on a small globular protein (SpyCatcher) that...