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Tension activation of mechanosensitive two-pore domain K+ channels TRAAK, TREK-1, and TREK-2
TRAAK, TREK-1, and TREK-2 are mechanosensitive two-pore domain K+ (K2P) channels that contribute to action potential propagation, sensory...
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Mechanosensitive Channels: History, Diversity, and Mechanisms
Abstract —Mechanical forces are inseparable from most cellular functions. Cell division, contraction, and adhesion generate intrinsic forces in the...
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Investigating mechanosensitive channels activation in concert with the mechanical properties of red blood cells
The activity of the mechanosensitive Ca 2+ permeable channels expressed in the membrane of the red blood cells (RBC) is determined both by the...
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Deciphering the role of mechanosensitive channels in plant root biology: perception, signaling, and adaptive responses
Main conclusionMechanosensitive channels are integral membrane proteins that rapidly translate extrinsic or intrinsic mechanical tensions into...
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Asymmetric effects of amphipathic molecules on mechanosensitive channels
Mechanosensitive (MS) ion channels are primary transducers of mechanical force into electrical and/or chemical intracellular signals. Many diverse MS...
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Hypergravity Increases the Number of Gene Transcripts of Mechanically Gated and Mechanosensitive Ion Channels in Rat Ventricular Cardiomyocytes
Since hypergravity changes the morphological and physiological properties of the heart, it was assumed that the expression of ion channels that...
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Mechanosensitive aquaporins
Cellular systems must deal with mechanical forces to satisfy their physiological functions. In this context, proteins with mechanosensitive...
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Simulated Microgravity Changes the Number of Mechanically Gated and Mechanosensitive Ion Channels Genes Transcripts in Rat Ventricular Cardiomyocytes
AbstractThe mechanoelectrical feedback in the heart is based on the work of mechanically gated (MGCs) and mechanosensitive (MSCs) channels. Since...
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Analysis of Possible Mechanisms of Endometrial Stem Cell Migration Suppression by Selective Chemical Activation of Piezo1 Mechanosensitive Channels
AbstractWe investigated the possible molecular mechanisms that could mediate the suppression of cell motility of human endometrial mesenchymal stem...
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Emerging roles of mechanosensitive ion channels in acute lung injury/acute respiratory distress syndrome
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a devastating respiratory disorder with high rates of mortality and morbidity,...
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Axonal membrane stretch suppresses neuronal excitability by activating mechanosensitive K2P channels at the node of Ranvier
Saltatory conduction is the propagation of action potentials along myelinated nerves, which enables fast propagation through the node of Ranvier....
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Mechanosensitive Piezo channels mediate the physiological and pathophysiological changes in the respiratory system
Mechanosensitive Piezo ion channels were first reported in 2010 in a mouse neuroblastoma cell line, opening up a new field for studying the...
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Mechanosensitive receptors in migraine: a systematic review
BackgroundMigraine is a debilitating neurological disorder with pain profile, suggesting exaggerated mechanosensation. Mechanosensitive receptors of...
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Mechanosensitive ion channel gene survey suggests potential roles in primary open angle glaucoma
Although glaucoma is a disease modulated by eye pressure, the mechanisms of pressure sensing in the eye are not well understood. Here, we...
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Origin, evolution and diversification of plant mechanosensitive channel of small conductance-like (MSL) proteins
Mechanosensitive (MS) ion channels provide efficient molecular mechanism for transducing mechanical forces into intracellular ion fluxes in all...
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Open structure and gating of the Arabidopsis mechanosensitive ion channel MSL10
Plants are challenged by drastically different osmotic environments during growth and development. Adaptation to these environments often involves...
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Membrane phospholipids control gating of the mechanosensitive potassium leak channel TREK1
Tandem pore domain (K2P) potassium channels modulate resting membrane potentials and shape cellular excitability. For the mechanosensitive subfamily...
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MCAs in Arabidopsis are Ca2+-permeable mechanosensitive channels inherently sensitive to membrane tension
Mechanosensitive (MS) ion channels respond to mechanical stress and convert it into intracellular electric and ionic signals. Five MS channel...
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Mechanosensitive TRPV4 channel guides maturation and organization of the bilayered mammary epithelium
Biophysical cues from the cell microenvironment are detected by mechanosensitive components at the cell surface. Such machineries convert physical...
