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Hematopoiesis
Hematopoiesis refers to the development of cellular blood components, which starts during the embryonic phase of life and continues throughout...
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Learning from Zebrafish Hematopoiesis
Hematopoiesis is a complex process that tightly regulates the generation, proliferation, differentiation, and maintenance of hematopoietic cells....
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Extramedullary hematopoiesis in cancer
Hematopoiesis can occur outside of the bone marrow during inflammatory stress to increase the production of primarily myeloid cells at extramedullary...
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Exploring hematopoiesis in zebrafish using forward genetic screening
Zebrafish have emerged as a powerful animal model for investigating the genetic basis of hematopoiesis. Owing to its close genetic and developmental...
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A novel computational method enables RNA editome profiling during human hematopoiesis from scRNA-seq data
RNA editing is a post-transcriptional modification with a cell-specific manner and important biological implications. Although single-cell RNA-seq...
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Bone marrow adipocytes fuel emergency hematopoiesis after myocardial infarction
After myocardial infarction (MI), emergency hematopoiesis produces inflammatory myeloid cells that accelerate atherosclerosis and promote heart...
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Interpreting variants in genes affected by clonal hematopoiesis in population data
Reference population databases like the Genome Aggregation Database (gnomAD) have improved our ability to interpret the human genome. Variant...
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miRNA-7145-cuedc2 axis controls hematopoiesis through JAK1/STAT3 signaling pathway
Hematopoiesis ensures tissue oxygenation, and remodeling as well as immune protection in vertebrates. During embryogenesis, hemangioblasts are the...
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SETBP1 is dispensable for normal and malignant hematopoiesis
SETBP1 is a potential epigenetic regulator whose hotspot mutations preventing proteasomal degradation are recurrently detected in myeloid...
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Adaptive and Maladaptive Clonal Hematopoiesis in Telomere Biology Disorders
Purpose of ReviewTelomere biology disorders (TBDs) are germline-inherited conditions characterized by reduction in telomerase function, accelerated...
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The Origin of Clonal Hematopoiesis and Its Implication in Human Diseases
Clonal expansion of hematopoietic cells is first observed in hematological malignancies where all the leukemic cells can be traced back to a single...
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Insight into microRNAs’ involvement in hematopoiesis: current standing point of findings
Hematopoiesis is a complex process in which hematopoietic stem cells are differentiated into all mature blood cells (red blood cells, white blood...
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Clonal hematopoiesis related TET2 loss-of-function impedes IL1β-mediated epigenetic reprogramming in hematopoietic stem and progenitor cells
Clonal hematopoiesis (CH) is defined as a single hematopoietic stem/progenitor cell (HSPC) gaining selective advantage over a broader range of HSPCs....
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Basic Hematopoiesis and Leukemia Stem Cells
There have been significant advances in the knowledge and understanding of hematopoiesis over the last century. Detailed functional, phenotypic, and...
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Lymphoid clonal hematopoiesis: implications for malignancy, immunity, and treatment
Clonal hematopoiesis (CH) is the age-related expansion of hematopoietic stem cell clones caused by the acquisition of somatic point mutations or...
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DDX41 haploinsufficiency causes inefficient hematopoiesis under stress and cooperates with p53 mutations to cause hematologic malignancy
Germline heterozygous mutations in DDX41 predispose individuals to hematologic malignancies in adulthood. Most of these DDX41 mutations result in a...
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Clonal hematopoiesis of a novel dic(18;20) clone following allogeneic hematopoietic stem cell transplantation
A 55-year-old man in first complete remission of acute myeloid leukemia with a normal karyotype underwent allogeneic hematopoietic stem cell...
