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Presence of a long nuclear-localization signal sequence in homeodomain transcription factor Nkx1.2
Homeodomains, a 60-amino acid sequence encoded by 180 nucleotides, are highly conserved DNA-binding motifs that are present in a variety of...
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In Silico Characterization of Pathogenic Homeodomain Missense Mutations in the PITX2 Gene
Paired homologous domain transcription factor 2 (PITX2) is critically involved in ocular and cardiac development. Mutations in PITX2 are consistently...
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A cationic motif upstream Engrailed2 homeodomain controls cell internalization through selective interaction with heparan sulfates
Engrailed2 (En2) is a transcription factor that transfers from cell to cell through unconventional pathways. The poorly understood internalization...
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The homeodomain transcription factor CEH-37 regulates PMK-1/p38 MAPK pathway to protect against intestinal infection via the phosphatase VHP-1
Increasing evidence indicate that the expression of defense genes at the right place and the right time are regulated by host-defense transcription...
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In silico and computational analysis of zinc finger motif-associated homeodomain (ZF-HD) family genes in chilli (Capsicum annuum L)
Zinc finger-homeodomain (ZHD) proteins are mostly expressed in plants and are involved in proper growth and development and minimizing biotic and...
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Role of moss and Arabidopsis zinc-finger homeodomain transcription factors in regulating plant architecture
Zinc-finger homeodomain transcription factors (ZF-HD TFs) are relatively a small gene family in Arabidopsis involved in plant development and stress...
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DNA binding analysis of rare variants in homeodomains reveals homeodomain specificity-determining residues
Homeodomains (HDs) are the second largest class of DNA binding domains (DBDs) among eukaryotic sequence-specific transcription factors (TFs) and are...
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Genome-wide characterization of the TALE homeodomain family and the KNOX-BLH interaction network in tomato
Key messageComprehensive yeast and protoplast two-hybrid analyses illustrated the protein–protein interaction network of the TALE homeodomain protein...
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Overexpression of microRNA-205-5p promotes cholangiocarcinoma growth by reducing expression of homeodomain-interacting protein kinase 3
The microRNA miR-205-5p has diverse effects in different malignancies, including cholangiocarcinoma (CCA), but its effects on CCA progression is...
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The homeodomain transcriptional regulator DVE-1 directs a program for synapse elimination during circuit remodeling
The elimination of synapses during circuit remodeling is critical for brain maturation; however, the molecular mechanisms directing synapse...
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Genome-wide analysis of zinc finger-homeodomain (ZF-HD) transcription factors in diploid and tetraploid cotton
ZF-HD (zinc finger-homeodomain) gene family plays important roles in plant growth, development, and various stress responses. In the present study,...
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Characterization of a Homeodomain-Leucine Zipper Gene 12: Gene Silencing in Pepper and Arabidopsis-Based Overexpression During Abiotic Stress
Homeodomain-Leucine Zipper (HD-Zip) proteins are important ubiquitous and diverse molecular chaperones in plants. We characterized a gene CaATHB-12 ...
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Genome-Wide Identification, Expression, and Interaction Analysis of BEL-Like Homeodomain Gene Family in Peach
BEL1-like homeodomain (BLH) family genes as homeodomain transcription factors are found ubiquitously in plants to play important regulatory roles in...
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Comprehensive bioinformation analysis of homeodomain-leucine zipper gene family and expression pattern of HD-Zip I under abiotic stress in Salix suchowensis
BackgroundHomeodomain-leucine zipper (HD-Zip) transcription factors are plant-specific and play important roles in plant defense against...
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Homeodomain Transcription Factors Nkx2.2 and Pax6 as Novel Biomarkers for Meningioma Tumor Treatment
Meningioma is a common brain tumour which has neither a specific detection nor treatment method. The Sonic hedgehog (Shh) cell signaling pathway is a...
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Possible Role of Prep1 Homeodomain Transcription Factor in Cardiac Mesenchymal Stromal Cells
Abstract —Homeodomain transcription factors play a significant role in mesenchymal stromal cells (MSCs). Previously, the role of Meis1, Pbx1 and Prep1...
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Genome-wide identification of the plant homeodomain-finger family in rye and ScPHD5 functions in cold tolerance and flowering time
Key message111 PHD genes were newly identified in rye genome and ScPHD5’s role in regulating cold tolerance and flowering time was suggested.
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Identification and characterization of stress responsive homeodomain leucine zipper transcription factors in Medicago truncatula
BackgroundHomeodomain leucine zipper (HD-ZIP) transcription factors play roles in regulating plant development and responses to abiotic stresses;...
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The significance of homeodomain transcription factor 2 in colon cancer cells
BackgroundColon cancer is a serious malignant tumor. It has been reported that paired-like homeodomain transcription factor 2 (PITX2) can promote the...
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CcBLH6, a bell-like homeodomain-containing transcription factor, regulates the fruit lignification pattern
Main conclusionCcBLH6 is a bell-like homeodomain-containing transcription factor that plays an important role of lignin biosynthesis in the control...
