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A Purkinje cell to parabrachial nucleus pathway enables broad cerebellar influence over the forebrain
In addition to its motor functions, the cerebellum is involved in emotional regulation, anxiety and affect. We found that suppressing the firing of...
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Basal forebrain volume and metabolism in carriers of the Colombian mutation for autosomal dominant Alzheimer’s disease
We aimed to study atrophy and glucose metabolism of the cholinergic basal forebrain in non-demented mutation carriers for autosomal dominant...
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Development and Developmental Disorders of the Forebrain
The forebrain comprises those structures that are derived from the most rostral part of the neural plate, i.e. the primary prosencephalon. The...
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Generation of iPSC-derived human forebrain organoids assembling bilateral eye primordia
Induced pluripotent stem cell-derived brain organoids enable the developmental complexities of the human brain to be deconstructed. During...
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Cell-type-resolved mosaicism reveals clonal dynamics of the human forebrain
Debate remains around the anatomical origins of specific brain cell subtypes and lineage relationships within the human forebrain
1 –7 . Thus, direct...
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Expression patterns of Piezo1 in the develo** mouse forebrain
Malformation during cortical development can disrupt the balance of excitatory and inhibitory neural circuits, contributing to various psychiatric...
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Parvalbumin-expressing basal forebrain neurons mediate learning from negative experience
Parvalbumin (PV)-expressing GABAergic neurons of the basal forebrain (BFPVNs) were proposed to serve as a rapid and transient arousal system, yet...
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Basal forebrain cholinergic signalling: development, connectivity and roles in cognition
Acetylcholine plays an essential role in fundamental aspects of cognition. Studies that have mapped the activity and functional connectivity of...
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taVNS Alleviates Sevoflurane-Induced Cognitive Dysfunction in Aged Rats Via Activating Basal Forebrain Cholinergic Neurons
Postoperative cognitive dysfunction (POCD) is a common complication of central nervous system after anesthesia or surgery. Sevoflurane, an inhalation...
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Anatomical organization of forebrain circuits in the primate
The primate forebrain is a complex structure. Thousands of connections have been identified between cortical areas, and between cortical and...
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Developmental loss of NMDA receptors results in supernumerary forebrain neurons through delayed maturation of transit-amplifying neuroblasts
Developmental neurogenesis is a tightly regulated spatiotemporal process with its dysregulation implicated in neurodevelopmental disorders. NMDA...
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Evolutionary relevance of single nucleotide variants within the forebrain exclusive human accelerated enhancer regions
BackgroundHuman accelerated regions (HARs) are short conserved genomic sequences that have acquired significantly more nucleotide substitutions than...
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Spatially resolved cell atlas of the teleost telencephalon and deep homology of the vertebrate forebrain
The telencephalon has undergone remarkable diversification and expansion throughout vertebrate evolution, exhibiting striking variations in...
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Intranasal Insulin Administration to Rats with Forebrain Ischemia and Reperfusion Injury Reduces Autophagy and Apoptosis Intensity in the Hippocampus and Frontal Cortex, a Possible Mechanism of Action
AbstractRat forebrain ischemia followed by a 3-day reperfusion led to an increase in the levels of the autophagic marker LC3B-II and glial fibrillary...
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Comparative MRI analysis of the forebrain of three sauropsida models
The study of the brain by magnetic resonance imaging (MRI) allows to obtain detailed anatomical images, useful to describe specific encephalic...
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Characterization of enhancer activity in early human neurodevelopment using Massively Parallel Reporter Assay (MPRA) and forebrain organoids
Regulation of gene expression through enhancers is one of the major processes sha** the structure and function of the human brain during...
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An epigenome atlas of neural progenitors within the embryonic mouse forebrain
A comprehensive characterization of epigenomic organization in the embryonic mouse forebrain will enhance our understanding of neurodevelopment and...
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Functional neurogenomic responses to acoustic threats, including a heterospecific referential alarm call and its referent, in the auditory forebrain of red-winged blackbirds
In animal communication, functionally referential alarm calls elicit the same behavioral responses as their referents, despite their typically...
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Forebrain corticosteroid receptors promote post-myocardial infarction depression and mortality
Myocardial infarction (MI) with subsequent depression is associated with increased cardiac mortality. Impaired central mineralocorticoid (MR) and...
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Activation of basal forebrain-to-lateral habenula circuitry drives reflexive aversion and suppresses feeding behavior
Environmental cues and internal states such as mood, reward, or aversion directly influence feeding behaviors beyond homeostatic necessity. The...
