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Focal Adhesion
In the previous chapter, we learned about various biomaterial surfaces used for tissue engineering applications. Successful biomaterial surfaces...
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Polarized focal adhesion kinase activity within a focal adhesion during cell migration
Focal adhesion kinase (FAK) relays integrin signaling from outside to inside cells and contributes to cell adhesion and motility. However, the...
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Membrane-induced 2D phase separation of the focal adhesion protein talin
Focal adhesions form liquid-like assemblies around activated integrin receptors at the plasma membrane. How they achieve their flexible properties is...
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Hax1 regulate focal adhesion dynamics through IQGAP1
Cell migration is a highly orchestrated process requiring the coordination between the cytoskeleton, cell membrane and extracellular matrix...
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Remodeling of the focal adhesion complex by hydrogen-peroxide-induced senescence
Cellular senescence is a phenotype characterized by cessation of cell division, which can be caused by exhaustive replication or environmental...
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Electronic Structure Analysis of Dasatinib Inhibition of Focal Adhesion Kinase
A theoretical analysis was conducted using the DFT method with the ωB97XD functional to determine the binding energies of established inhibitors and...
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Focal adhesion kinase: from biological functions to therapeutic strategies
Focal adhesion kinase (FAK), a nonreceptor cytoplasmic tyrosine kinase, is a vital participant in primary cellular functions, such as proliferation,...
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Acinar to β-like cell conversion through inhibition of focal adhesion kinase
Insufficient functional β-cell mass causes diabetes; however, an effective cell replacement therapy for curing diabetes is currently not available....
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Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study
Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action is incompletely understood, and prediction of...
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Identification of a novel type of focal adhesion remodelling via FAK/FRNK replacement, and its contribution to cancer progression
Numerous studies have investigated the various cellular responses against genotoxic stress, including those mediated by focal adhesions. We here...
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Establishing and Validating an Innovative Focal Adhesion-Linked Gene Signature for Enhanced Prognostic Assessment in Endometrial Cancer
AbstractStudies have highlighted the significant role of focal adhesion signaling in cancer. Nevertheless, its specific involvement in the...
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Unusual effects of a nanoporous gold substrate on cell adhesion and differentiation because of independent multi-branch signaling of focal adhesions
A variety of cell behaviors, such as cell adhesion, motility, and fate, can be controlled by substrate characteristics such as surface topology and...
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Effect of Focal Adhesion Kinase and Vinculin Expression on Migration Parameters of Normal and Tumor Epitheliocytes
AbstractFocal adhesions (FAs) are mechanosensory structures that transform physical stimuli into chemical signals guiding cell migration....
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Focal adhesion is associated with lithium response in bipolar disorder: evidence from a network-based multi-omics analysis
Lithium (Li) is one of the most effective drugs for treating bipolar disorder (BD), however, there is presently no way to predict response to guide...
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ERRα coordinates actin and focal adhesion dynamics
Cell migration depends on the dynamic organisation of the actin cytoskeleton and assembly and disassembly of focal adhesions (FAs). However, the...
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Cellular nanomechanics derived from pattern-dependent focal adhesion and cytoskeleton to balance gene transfection of malignant osteosarcoma
Gene transfection was supposed to be the most promising technology to overcome the vast majority of diseases and it has been popularly reported in...
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Focal adhesion kinase-YAP signaling axis drives drug-tolerant persister cells and residual disease in lung cancer
Targeted therapy is effective in many tumor types including lung cancer, the leading cause of cancer mortality. Paradigm defining examples are...
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Kisspeptin-10 increases collagen content in the myocardium by focal adhesion kinase activity
The aim of the study was to evaluate the role of kisspeptin-10 (KiSS-10) in the regulation of collagen content in cardiac fibroblasts. An attempt was...
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Ebastine impairs metastatic spread in triple-negative breast cancer by targeting focal adhesion kinase
We sought to investigate the utility of ebastine (EBA), a second-generation antihistamine with potent anti-metastatic properties, in the context of...
