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Conjugates of Desmycosin with Fragments of Antimicrobial Peptide Oncocin: Synthesis, Antibacterial Activity, Interaction with Ribosome
AbstractDesign and synthesis of conjugates consisting of the macrolide antibiotic desmycosin and fragments of the antibacterial peptide oncocin were...
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Tylosin A and desmycosin in honey by salting-out assisted liquid-liquid extraction and aqueous normal phase ultraperformance liquid chromatography-tandem mass spectrometry
A simple and rapid method was developed for the determination of tylosin A and desmycosin residues in honey. Aliquots of honey samples were dissolved...
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Re-evaluation of a microbiological acceptable daily intake for tylosin based on its impact on human intestinal microflora
As veterinary drugs available for fish is very restricted, there is growing trials for repurposing livestock drugs as aquatic animal drugs. Tylosin...
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Microextraction Recovery of Tilmicosin Phosphate for HPLC-UV Determination in Washings from Surfaces of Pharmaceutical Equipment
A method for microextraction recovery and concentration of tilmicosin phosphate in washings from surfaces of pharmaceutical equipment for its...
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Molecularly Imprinted Polymers: Cutting-Edge Characterization Strategies
Molecularly Imprinted Polymers (MIPs), also known as synthetic antibodies or plastic antibodies, can be prepared using various polymerization methods...
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Highly Specific Anti-tylosin Monoclonal Antibody and Its Application in the Quantum Dot Bead-Based Immunochromatographic Assay
In this study, mAb-5A7 and mAb-1D7, two highly specific monoclonal antibodies against tylosin (TYL), were prepared by using hapten...
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Bioconversion of cow manure through vermicomposting: effects of tylosin concentration on the weight of worms and manure quality
This study investigated batch-fed vermicomposting of cow manure, with a specific focus on assessing the effects of tylosin on the weight of...
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Nanomaterial-Based Sensors for Macrolide Sensing
Recent developments in nanotechnology have empowered researchers to significantly advance all biomes of research, including sensing or detection of...
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Metabolites of soil microorganisms modulate amyloid β production in Alzheimer’s neurons
Microbial flora is investigated to be related with neuropathological conditions in Alzheimer’s disease (AD), and is attracting attention as a drug...
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Aldsulfin, a novel unusual anti-mannheimiosis epithiodiketopiperazine antibiotic produced by Lasiodiplodia pseudotheobromae FKI-4499
An anti-mannheimiosis agent, aldsulfin, was isolated from a culture broth of the fungus Lasiodiplodia pseudotheobromae FKI-4499, together with a...
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Determination of antimicrobial agents and their transformation products in an agricultural water-soil system modified with manure
Manure fertilization is the primary source of veterinary antimicrobials in the water-soil system. The research gap is the fate of antimicrobials...
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Effect of Antibiotics on Plant Growth in a Water Culture
The primary entrance pathways of antibiotics in the environment are through wastewater and spreading animal manure as a mean of irrigation and...
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Application of modified Michaelis – Menten equations for determination of enzyme inducing and inhibiting drugs
BackgroundPharmacokinetics (PK) is the process of absorption, distribution, metabolism and elimination (ADME) of drugs. Some drugs undergo zero-order...
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l-Carnitine and vitamin E ameliorate cardiotoxicity induced by tilmicosin in rats
The present study aimed to investigate the possible mitigating effect of l -carnitine (LC) and/or α-tocopherol (Vit. E) administration against...
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Protective potency of Astragalus polysaccharides against tilmicosin- induced cardiac injury via targeting oxidative stress and cell apoptosis-encoding pathways in rat
Tilmicosin (Til) was purposed to be used in the treatment of a wide range of respiratory diseases in livestock. However, undesirable adverse effects,...
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Consistency evaluation between matrix components ratio and microbiological potency of tylosin major components
BackgroundThe aim of our research work was to investigate the relative potencies of matrix components of tylosin, a multi-component antibiotic, and...
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5-O-Mycaminosyltylonolide antibacterial derivatives: design, synthesis and bioactivity
Tylosin is a 16-membered macrolide broad-spectrum antibiotic that has an important role in veterinary medicine, active against Gram-positive and a...
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New fluorescent macrolide derivatives for studying interactions of antibiotics and their analogs with the ribosomal exit tunnel
Novel fluorescent derivatives of macrolide antibiotics related to tylosin bearing rhodamine, fluorescein, Alexa Fluor 488, BODIPY FL, and...
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Natural product discovery: past, present, and future
Microorganisms have provided abundant sources of natural products which have been developed as commercial products for human medicine, animal health,...
