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Cytoplasmic delivery of siRNA using human-derived membrane penetration-enhancing peptide
BackgroundAlthough protein-based methods using cell-penetrating peptides such as TAT have been expected to provide an alternative approach to siRNA...
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Nanotechnology for Enhanced Cytoplasmic and Organelle Delivery of Bioactive Molecules to Immune Cells
Immune cells stand as a critical component of the immune system to maintain the internal environment homeostasis. The dysfunction of immune cells can...
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Cytoplasmic Delivery of Bioactives
Most therapeutic agents are designed to exert their pharmacological actions by modulating intracellular components targeting specific organelles.... -
Strategy for Cytoplasmic Delivery Using Inorganic Particles
Endosome escape is a key process for intracellular uptake of intact biomolecules and therapeutics, such as nucleic acids. Lysosome escape is a more...
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Competitive binding and molecular crowding regulate the cytoplasmic interactome of non-viral polymeric gene delivery vectors
In contrast to the processes controlling the complexation, targeting and uptake of polycationic gene delivery vectors, the molecular mechanisms...
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Nanoparticle-Mediated Cytoplasmic Delivery of Messenger RNA Vaccines: Challenges and Future Perspectives
The COVID-19 pandemic has left scientists and clinicians no choice but a race to find solutions to save lives while controlling the rapid spreading....
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Nuclear and cytoplasmic specific RNA binding proteome enrichment and its changes upon ferroptosis induction
The key role of RNA-binding proteins (RBPs) in posttranscriptional regulation of gene expression is intimately tied to their subcellular...
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Engineering the Tat-secretion pathway of Bacillus licheniformis for the secretion of cytoplasmic enzyme arginase
AbstractThe industrial bacterium Bacillus licheniformis has long been used as a microbial factory for the production of enzymes due to its ability...
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Gene Delivery Using Polymer Therapeutics
The use of polymers as synthetic non-viral carriers for introducing nucleic acids into cells appears very appealing. Polymers can be generated in...
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Effect of cytoplasmic fragmentation on embryo development, quality, and pregnancy outcome: a systematic review of the literature
The role of cytoplasmic fragmentation in human embryo development and reproductive potential is widely recognized, albeit without standard definition...
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Connexin-Containing Vesicles for Drug Delivery
Connexin is a transmembrane protein present on the cell membrane of most cell types. Connexins assemble into a hexameric hemichannel known as...
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N2FXm, a method for joint nuclear and cytoplasmic volume measurements, unravels the osmo-mechanical regulation of nuclear volume in mammalian cells
In eukaryotes, cytoplasmic and nuclear volumes are tightly regulated to ensure proper cell homeostasis. However, current methods to measure...
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Drug Delivery Systems for Muscles
Muscle diseases and disorders can cause a loss of function and mobility, significantly reducing the quality of life for patients and their...
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Nuclear and cytoplasmic spatial protein quality control is coordinated by nuclear–vacuolar junctions and perinuclear ESCRT
Effective protein quality control (PQC), essential for cellular health, relies on spatial sequestration of misfolded proteins into defined...
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Microinjection-Based Drug Delivery
Microinjection is a gold standard technique to understand physiological and pathological processes at single-cell level; as well as has applications...
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RNA Delivery to Mitochondria
The approval of mRNA-containing lipid nanoparticles (LNPs) for use in a vaccine against the severe acute respiratory syndrome coronavirus 2...
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Nonviral Delivery of Cancer Genetic Vaccines
The potential use of genetic vaccines to address numerous diseases including cancer is promising, but currently unrealized. Here, we review...
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Synbiotics in Oral Drug Delivery
Gut microbiota constitutes a variety of microorganism like bacteria, fungi, virus, rickettsiae, etc. Any imbalance in gut microbiota termed as...
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Single molecule delivery into living cells
Controlled manipulation of cultured cells by delivery of exogenous macromolecules is a cornerstone of experimental biology. Here we describe a...
