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Structural insights into cardiolipin replacement by phosphatidylglycerol in a cardiolipin-lacking yeast respiratory supercomplex
Cardiolipin is a hallmark phospholipid of mitochondrial membranes. Despite established significance of cardiolipin in supporting respiratory...
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Peculiarities of Cytochrome c Enzymatic Activity with Cardiolipin
AbstractThe points of enzymatic activity, quantum yields, structure, functions of luminol chemiluminescence activated by physical activators natural...
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ALCAT1-mediated abnormal cardiolipin remodelling promotes mitochondrial injury in podocytes in diabetic kidney disease
BackgroundCardiolipin (CL) plays a critical role in maintaining mitochondrial membrane integrity and overall mitochondrial homeostasis. Recent...
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Modeling of the Interaction of Cytochrome c with Cardiolipin
AbstractInteractions of horse heart cytochrome c (Cyt c ) with cardiolipin molecules were modeled by molecular dynamics simulations. It was shown...
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Obesity impairs cardiolipin-dependent mitophagy and therapeutic intercellular mitochondrial transfer ability of mesenchymal stem cells
Mesenchymal stem cell (MSC) transplantation alleviates metabolic defects in diseased recipient cells by intercellular mitochondrial transport (IMT)....
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Severe COVID-19 patients exhibit elevated levels of autoantibodies targeting cardiolipin and platelet glycoprotein with age: a systems biology approach
Age is a significant risk factor for the coronavirus disease 2019 (COVID-19) severity due to immunosenescence and certain age-dependent medical...
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Two mitochondrial DNA polymorphisms modulate cardiolipin binding and lead to synthetic lethality
Genetic screens have been used extensively to probe interactions between nuclear genes and their impact on phenotypes. Probing interactions between...
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Aggregation of alpha-synuclein disrupts mitochondrial metabolism and induce mitophagy via cardiolipin externalization
Accumulation of α-synuclein aggregates in the substantia nigra pars compacta is central in the pathophysiology of Parkinson’s disease, leading to the...
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Modeling of Quantum Yields, Structure and Function of Cytochrome C and Cardiolipin: Its Enzymatic Activity and Free Radical Processes
AbstractQuantum yields, structure, and enzymatic activity points of coumarin–activated C-334 chemiluminescence of lipid peroxidation processes under...
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Impact of acute heat stress on mitochondrial function, ultrastructure and cardiolipin distribution in Arabidopsis
Besides providing energy to sustain life, mitochondria also play crucial roles in stress response and programmed cell death. The mitochondrial...
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Restoring mitochondrial cardiolipin homeostasis reduces cell death and promotes recovery after spinal cord injury
Alterations in phospholipids have long been associated with spinal cord injury (SCI). However, their specific roles and signaling cascades in...
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SARS CoV- 2 vaccination induces antibodies against cardiolipin
ObjectiveCases of thrombosis have been reported after administration of SARS-CoV-2 vaccines, with controversial results relating to...
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An in vitro-transcribed circular RNA targets the mitochondrial inner membrane cardiolipin to ablate EIF4G2+/PTBP1+ pan-adenocarcinoma
In vitro-transcribed (IVT) mRNA has arisen as a rapid method for the production of nucleic acid drugs. Here, we have constructed an oncolytic IVT...
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Dynamics and stabilization mechanism of mitochondrial cristae morphofunction associated with turgor-driven cardiolipin biosynthesis under salt stress conditions
Maintaining energy production efficiency is of vital importance to plants growing under changing environments. Cardiolipin localized in the inner...
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Anti-cardiolipin IgG autoantibodies associate with circulating extracellular DNA in severe COVID-19
Whereas the detection of antiphospholipid autoantibodies (aPL) in COVID-19 is of increasing interest, their role is still unclear. We analyzed a...
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The Use of Quinolizidine Derivatives of Coumarin in the Studies of the Mechanisms of Action of the Cytochrome c–Cardiolipin Complex
AbstractThe cytochrome c –cardiolipin complex plays a key role in triggering apoptosis via the mitochondrial pathway due to lipoperoxidase and...
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Antiphospholipid Antibody Testing for Anti-cardiolipin and Anti-β2 Glycoprotein I Antibodies Using Chemiluminescence-Based Panels
Antiphospholipid (antibody) syndrome (APS) is a prothrombotic condition with increased risk for thrombosis and pregnancy-related morbidity. In...
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Integrated lipidomics and proteomics reveal cardiolipin alterations, upregulation of HADHA and long chain fatty acids in pancreatic cancer stem cells
Pancreatic cancer stem cells (PCSCs) play a key role in the aggressiveness of pancreatic ductal adenocarcinomas (PDAC); however, little is known...
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The Destruction of Cytochrome c in a Complex with Cardiolipin during Catalysis of Lipid Peroxidation
The destruction of cytochrome c during its catalysis of the lipoperoxidase reaction, which causes the impairment of mitochondrial membranes in living...
