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Invasion and Metastatic Potential of Cancer Stem Cells In Vitro
In order to fight against cancer, it is critical to study cellular migration, invasion, and adhesion, which are the pivotal steps of metastasis.... -
A YAP-centered mechanotransduction loop drives collective breast cancer cell invasion
Dense and aligned Collagen I fibers are associated with collective cancer invasion led by protrusive tumor cells, leader cells. In some breast...
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Targeting cholesterol impairs cell invasion of all breast cancer types
BackgroundBreast cancer clinical outcome relies on its intrinsic molecular subtype and mortality is almost exclusively due to metastasis, whose...
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Surgical Management of Locally Advanced Thyroid Cancer with Tracheal Invasion
Locally advanced disease occurs in approximately 10-15% of patients with differentiated thyroid cancer. While minimal invasion into strap muscles are... -
PLK1 phosphorylates RhoGDI1 and promotes cancer cell migration and invasion
BackgroundRho guanine nucleotide dissociation inhibitor 1 (RhoGDI1) plays an important role in diverse cellular processes by regulating Rho guanosine...
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Analysis of Energy-Driven Leader-Follower Hierarchy During Collective Cancer Cell Invasion
Many solid tumors can invade the surrounding three-dimensional (3D) tissue in a collective manner, and increasing evidence suggests that collective... -
Invasion and Metastasis
This chapter delineates processes, molecules, and interactions contributing to invasion and metastasis, the most defining properties of malignancy.... -
Cancer-Associated Fibroblast-Secreted Exosomes Promote Gastric Cancer Cell Migration and Invasion via the IL-32/ESR1 Axis
Exosomes secreted by cancer-associated fibroblasts (CAFs) play a critical part in cancer progression. This study aimed to explore the effects of...
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The miR-1290/OGN axis in ovarian cancer-associated fibroblasts modulates cancer cell proliferation and invasion
Despite receiving first-line treatment, ovarian cancer patients continue to experience a high rate of recurrence; nearly all women with ovarian...
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The depth of perineural invasion is an independent prognostic factor for stage II colorectal cancer
BackgroundPerineural invasion (PNI) is the invasion of nerves by cancer cells and is associated with poor survival in stage II colorectal cancer....
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Neural Influence on Cancer Invasion and Metastasis
Nerves modulate the surrounding tissue to facilitate nerve repair and regeneration. This fascinating regenerative ability is demonstrated in case of... -
PLCD3 inhibits apoptosis and promotes proliferation, invasion and migration in gastric cancer
Gastric cancer (GC) is a heterogeneous disease whose development is accompanied by alterations in a variety of pathogenic genes. The phospholipase C...
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Prognostic significance and value of further classification of lymphovascular invasion in invasive breast cancer: a retrospective observational study
PurposeTo investigate the prognostic significance of lymphovascular invasion in invasive breast cancer and the value of using specific vascular...
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Invasion und Metastasierung
Dieses Kapitel beschreibt Prozesse, Moleküle und Wechselwirkungen, die zur Invasion und Metastasierung beitragen, die am stärksten definierenden... -
A prediction nomogram for perineural invasion in colorectal cancer patients: a retrospective study
BackgroundPerineural invasion (PNI), as the fifth recognized pathway for the spread and metastasis of colorectal cancer (CRC), has increasingly...
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Dicalcin suppresses invasion and metastasis of mammalian ovarian cancer cells by regulating the ganglioside-Erk1/2 axis
Metastasis, a multistep process including cancer cell migration and invasion, is the major cause of mortality in patients with cancer. Here, we...
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IFIT1 modulates the proliferation, migration and invasion of pancreatic cancer cells via Wnt/β-catenin signaling
ObjectivesPreviously, Interferon-induced Protein with Tetratricopeptide Repeats 1 (IFIT1) has been shown to promote cancer development. Here, we...
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A Genuinely Hybrid, Multiscale 3D Cancer Invasion and Metastasis Modelling Framework
We introduce in this paper substantial enhancements to a previously proposed hybrid multiscale cancer invasion modelling framework to better reflect...
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CSGALNACT2 restricts ovarian cancer migration and invasion by modulating MAPK/ERK pathway through DUSP1
PurposeOvarian cancer is one of the leading causes of cancer-related death among women. CSGALNACT2 is a vital Golgi transferase and is related to a...
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Mutant TP53 promotes invasion of lung cancer cells by regulating desmoglein 3
PurposeTargeted therapies have markedly improved the prognosis of lung cancer patients; nevertheless, challenges persist, including limited...