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Distribution of Oxygen Tension on Microvessels and in Tissue of Rat Brain Cortex at Severe Arterial Hypocapnia
AbstractArterial hypocapnia (AH), induced by voluntary or forced hyperventilation of the lungs, is accompanied by a decrease in cerebral blood...
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Targeting mitochondria in the aged cerebral vasculature with SS-31, a proteomic study of brain microvessels
Cognitive impairment and dementias during aging such as Alzheimer’s disease are linked to functional decline and structural alterations of the brain...
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Three-dimensional microenvironment regulates gene expression, function, and tight junction dynamics of iPSC-derived blood–brain barrier microvessels
The blood–brain barrier (BBB) plays a pivotal role in brain health and disease. In the BBB, brain microvascular endothelial cells (BMECs) are...
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Fibrinogen in mice cerebral microvessels induces blood–brain barrier dysregulation with aging via a dynamin-related protein 1–dependent pathway
We previously reported evidence that oxidative stress during aging leads to adverse protein profile changes of brain cortical microvessels (MVs: end...
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The proteome of the blood–brain barrier in rat and mouse: highly specific identification of proteins on the luminal surface of brain microvessels by in vivo glycocapture
BackgroundThe active transport of molecules into the brain from blood is regulated by receptors, transporters, and other cell surface proteins that...
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HIV Promotes Neurocognitive Impairment by Damaging the Hippocampal Microvessels
Current evidence suggests that mild cerebrovascular changes could induce neurodegeneration and contribute to HIV-associated neurocognitive disease...
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Protein Expression of Amino Acid Transporters Is Altered in Isolated Cerebral Microvessels of 5xFAD Mouse Model of Alzheimer’s Disease
Membrane transporters such as ATP-binding cassette (ABC) and solute carrier (SLC) transporters expressed at the neurovascular unit (NVU) play an...
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Computational Fractal-Based Analysis of Brain Tumor Microvascular Networks
Brain parenchyma microvasculature is set in disarray in the presence of tumors, and malignant brain tumors are among the most vascularized neoplasms...
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On P2X receptors in the brain: microvessels. Dedicated to the memory of the late Professor Geoffrey Burnstock (1929–2020)
This tribute article presents selected immunocytochemical and transmission electron microscope data on the location of ATP-gated P2X receptor in the...
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Role of interleukin-6 and interleukin-10 in morphological and functional changes of the blood–brain barrier in hypertriglyceridemia
BackgroundHypertriglyceridemia is closely linked to atherosclerosis related inflammatory processes and blood–brain barrier (BBB) dysfunction. Using...
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Metabolic Plasticity in Develo** and Aging Brain
Abstract —Brain plasticity is a fundamental phenomenon based on various types of intercellular interactions (synaptic activity, neuritogenesis,...
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High-Resolution Confocal Imaging of Pericytes in Human Fetal Brain Microvessels
Pericytes are integral part of neurovascular unit and play a role in the maintenance of blood-brain barrier integrity, angiogenesis, and cerebral...
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Three-dimensional visualization of human brain tumors using the CUBIC technique
Application of tissue clearing techniques on human brain tumors is still limited. This study was to investigate the application of CUBIC on 3D...
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Cerebral Microvessels
It has always been customary to remove the meninges prior to examining the brain. Deprived of meninges, the brain surface appears smooth and without...
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Increased Expression of Transferrin Receptor 1 in the Brain Cortex of 5xFAD Mouse Model of Alzheimer’s Disease Is Associated with Activation of HIF-1 Signaling Pathway
Alzheimer’s disease (AD) is the most common cause of dementia. Despite intensive research efforts, there are currently no effective treatments to...
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Endothelial cells and macrophages as allies in the healthy and diseased brain
Diseases of the central nervous system (CNS) are often associated with vascular disturbances or inflammation and frequently both. Consequently,...
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Morphological Features and Clinical Significance of Tumor Microvessels in Glandular and Squamous Cell Cancers
Angiogenesis plays a key role in the growth and metastasis of malignant tumors. The main purpose of this chapter is to discuss the key factors...
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ASK1-K716R reduces neuroinflammation and white matter injury via preserving blood–brain barrier integrity after traumatic brain injury
BackgroundTraumatic brain injury (TBI) is a significant worldwide public health concern that necessitates attention. Apoptosis signal-regulating...
