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A recombinant virus-like particle vaccine against adenovirus-7 induces a potent humoral response
Adenoviruses (AdVs) cause infections in humans that range from mild to severe, and can cause outbreaks particularly in close contact settings....
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Impact of Ebola virus nucleoprotein on VP40 virus-like particle production: a computational approach
Ebola virus (EBOV) matrix protein VP40 can assemble and bud as virus-like particles (VLPs) when expressed alone in mammalian cells. Nucleoprotein...
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Expression of dengue virus and Zika virus NS2B-NS3pro constructs alter cellular fatty acids, but co-expression with a Zika virus virus-like particle is detrimental to virus-like particle expression
ObjectiveStudies have shown that Flavivirus infection remodels the host cell to favour viral replication. In particular, the host cell lipid profile...
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Advancing usability of an influenza hemagglutinin virus-like particle vaccine expressing a chimeric cytokine
Vaccine efficacy of conventional influenza vaccines depend on the antigenic similarity between the selected vaccine strain and annual epidemic...
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Melt Processing Virus-Like Particle-Based Vaccine Candidates into Biodegradable Polymer Implants
Melt processing is an emerging production method to efficiently encapsulate proteins into polymeric devices for sustained release. In the context of...
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Design and Purification of Tag/Catcher AP205-Based Capsid Virus-Like Particle Vaccines
Capsid virus-like particles (cVLPs), assembled from viral coat proteins, are used as therapeutic cargo delivery vehicles as well as molecular...
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Plant Virus-Like Particles for RNA Delivery
Plant viruses such as brome mosaic virus and cowpea chlorotic mottle virus are effectively purified through PEG precipitation and sucrose cushion...
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Plant Molecular Farming: Production of Virus-like Particles in Plants
Plant molecular farmingPlant molecular farming, or biopharmingBiopharming, is the production of heterologous proteins in plants or plant cells. This...
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Virus-like particle vaccinology, from bench to bedside
Virus-like particles (VLPs) have become key tools in biology, medicine and even engineering. After their initial use to resolve viral structures at...
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A virus-like particle-based bivalent PCSK9 vaccine lowers LDL-cholesterol levels in non-human primates
Elevated low-density lipoprotein cholesterol (LDL-C) is an important risk factor in the development of atherosclerotic cardiovascular disease...
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Preclinical Evaluation of virus-like particle Vaccine Against Carbonic Anhydrase IX Efficacy in a Mouse Breast Cancer Model System
Carbonic anhydrase IX (CAIX) is a cancer-associated membrane protein frequently overexpressed in hypoxic solid tumours leading to enhanced tumour...
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Dendritic-cell-targeting virus-like particles as potent mRNA vaccine carriers
Messenger RNA vaccines lack specificity for dendritic cells (DCs)—the most effective cells at antigen presentation. Here we report the design and...
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Programmable polymorphism of a virus-like particle
Virus-like particles (VLPs) have significant potential as artificial vaccines and drug delivery systems. The ability to control their size has wide...
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Nanoparticle and virus-like particle vaccine approaches against SARS-CoV-2
The global spread of coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has provoked an urgent...
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Bacteriophage Virus-Like Particles: Platforms for Vaccine Design
Virus-like particles (VLPs) derived from bacteriophages have many applications in biomedical sciences, especially in the development of candidate...
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A virus like particle approach to study the Chikungunya virus envelope protein mutations
Virus like particles (VLPs) are used as a tool to study the mutations in the structural genes that influence the virus assembly and entry process. We...
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Virus-like particle vaccine displaying an external, membrane adjacent MUC16 epitope elicits ovarian cancer-reactive antibodies
BackgroundMUC16 is a heavily glycosylated cell surface mucin cleaved in the tumor microenvironment to shed CA125. CA125 is a serum biomarker...
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Durability and cross-reactivity of immune responses induced by a plant-based virus-like particle vaccine for COVID-19
As the SARS-CoV-2 pandemic evolves, vaccine evaluation needs to include consideration of both durability and cross-reactivity. This report expands on...
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Virus-like structures for combination antigen protein mRNA vaccination
Improved vaccination requires better delivery of antigens and activation of the natural immune response. Here we report a lipid nanoparticle system...
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Design of hepadnavirus core protein-based chimeric virus-like particles carrying epitopes from respiratory syncytial virus
Respiratory syncytial virus (RSV) is one of the most important pathogens causing respiratory tract infection in humans, especially in infants and the...
