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Viral RNA Is a Hub for Critical Host–Virus Interactions
RNA is a central molecule in the life cycle of viruses, acting not only as messenger (m)RNA but also as a genome. Given these critical roles, it is...
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DEAD box RNA helicase 5 is a new pro-viral host factor for Sindbis virus infection
BackgroundRNA helicases are emerging as key factors regulating host-virus interactions. The DEAD-box ATP-dependent RNA helicase DDX5, which plays an...
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Dengue virus pathogenesis and host molecular machineries
Dengue viruses (DENV) are positive-stranded RNA viruses belonging to the Flaviviridae family. DENV is the causative agent of dengue, the most rapidly...
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Comparative analysis of retroviral Gag-host cell interactions: focus on the nuclear interactome
Retroviruses exploit host proteins to assemble and release virions from infected cells. Previously, most studies focused on interacting partners of...
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Interactome profiling of Crimean-Congo hemorrhagic fever virus glycoproteins
Crimean-Congo hemorrhagic fever virus (CCHFV) is a biosafety level-4 pathogen requiring urgent research and development efforts. The glycoproteins of...
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A comprehensive SARS-CoV-2–human protein–protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets
Studying viral–host protein–protein interactions can facilitate the discovery of therapies for viral infection. We use high-throughput yeast...
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Isolation and Identification of Dengue Virus Interactome with Human Plasma Proteins by Affinity Purification-Mass Spectrometry
Viral proteins evolve to benefit the interaction with host proteins during the infection and replication processes. A comprehensive understanding of...
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Systematic HOIP interactome profiling reveals critical roles of linear ubiquitination in tissue homeostasis
Linear ubiquitination catalyzed by HOIL-1-interacting protein (HOIP), the key component of the linear ubiquitination assembly complex, plays...
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Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing
Coronavirus Disease-2019 (COVID-19) is an infectious disease caused by the SARS-CoV-2 virus. Various studies exist about the molecular mechanisms of...
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YWHAH, a member of 14-3-3 family proteins, and PSME2, the proteasome activator subunit 2, are key host factors of Japanese encephalitis virus infection
BackgroundHost response to virus infection is key to the effective control and eventual elimination of viruses or infected cells; however, the...
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Interactome of Paraoxonase PON2 Reveals New Pathways for Tumor Growth Regulation
AbstractThe interactome of paraoxonase-2 encoded by the PON2 gene was investigated. A cDNA library was screened using a yeast two-hybrid system to...
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Prediction of human protein interactome of dengue virus non-structural protein 5 (NS5) and its downstream immunological implications
The non-structural protein 5 (NS5) is the most conserved protein among flaviviruses, a family that includes the dengue virus. It functions both as an...
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Neuroimmune Mechanisms Underlying Post-acute Sequelae of SARS-CoV-2 (PASC) Pain, Predictions from a Ligand-Receptor Interactome
Purpose of ReviewIndividuals with post-acute sequelae of SARS-CoV-2 (PASC) complain of persistent musculoskeletal pain. Determining how COVID-19...
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Looking for pathways related to COVID-19: confirmation of pathogenic mechanisms by SARS-CoV-2–host interactome
In the last months, many studies have clearly described several mechanisms of SARS-CoV-2 infection at cell and tissue level, but the mechanisms of...
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Split-Luciferase Complementation for Analysis of Virus–Host Protein Interactions
Productive viral infection entails highly regulated and sequential protein–protein interactions between viral factors and between virus and host...
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Multiscale interactome analysis coupled with off-target drug predictions reveals drug repurposing candidates for human coronavirus disease
The COVID-19 pandemic has highlighted the urgent need for the identification of new antiviral drug therapies for a variety of diseases. COVID-19 is...
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Plant-Virus Interactions
This detailed volume provides practical guidance on techniques in plant-virus interaction research, from targeting specific molecular interactions...
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Analysis of Zika virus capsid-Aedes aegypti mosquito interactome reveals pro-viral host factors critical for establishing infection
The escalating global prevalence of arboviral diseases emphasizes the need to improve our understanding of their biology. Research in this area has...
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Comprehensive map** of SARS-CoV-2 interactions in vivo reveals functional virus-host interactions
SARS-CoV-2 is a major threat to global health. Here, we investigate the RNA structure and RNA-RNA interactions of wildtype (WT) and a mutant (Δ382)...
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Immunoprecipitation Followed by Mass Spectrometry: An Approach for Identifying Host–Viral Protein–Protein Interactions
As obligate intracellular parasites, viruses rely on the efficient manipulation of the cell they invade in order to multiply and spread....