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A Tumor Homing Peptide-Conjugated Poly(epsilon-lysine) Delivery System for Improved Antitumor Drug Loading and Targeting
The main challenges with conventional chemotherapeutic drugs are their non-selective toxicity and limited targeting abilities. Hence, it is...
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Enhancing the Stability of Tumor Homing LyP-1 Peptide Using Cyclization and Retro Grafting Strategies
Anticancer peptide therapeutics are promising candidates for cancer treatment as they are highly specific to their targets and can have tumor-homing...
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The influence of a modified p53 C-terminal peptide by using a tumor-targeting sequence on cellular apoptosis and tumor treatment
The restoration of the function of p53 in tumors is a therapeutic strategy for the highly frequent mutation of the TP53 tumor suppressor gene. P460...
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Tumor Homing Peptides as Fusion Partners of Therapeutic Proteins for Efficient Delivery to Cancer Cells
for practical protein therapeutics and diagnostics, it is necessary to develop a method that can effectively and specifically deliver proteins into...
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A Computational Predictor for Accurate Identification of Tumor Homing Peptides by Integrating Sequential and Deep BiLSTM Features
Cancer remains a severe illness, and current research indicates that tumor homing peptides (THPs) play an important part in cancer therapy. The...
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Molecular hybridization combining tumor homing and penetrating peptide domains for cellular targeting
A complete peptide-based drug delivery unit has been designed with a tumor homing domain chemically linked to a syndiotactic cell-penetrating domain....
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New Tools for Streamlined In Vivo Homing Peptide Identification
In vivo peptide-phage display is an unbiased technique for map** of the vascular diversity and identification of homing peptides. This chapter is...
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Hybridization of tumor homing and mitochondria-targeting peptide domains to design novel dual-imaging self-assembled peptide nanoparticles for theranostic applications
A novel hybridized dual-targeting peptide-based nanoprobe was successfully designed by using the cyclic heptapeptide. This peptide has...
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Tumor-specific intracellular delivery: peptide-guided transport of a catalytic toxin
There continues to be a need for cancer-specific ligands that can deliver a wide variety of therapeutic cargos. Ligands demonstrating both...
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Self-assembled peptide-dye nanostructures for in vivo tumor imaging and photodynamic toxicity
We report noncovalent assemblies of iRGD peptides and methylene blue dyes via electrostatic and hydrophobic stacking. These resulting nanomaterials...
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Tumor Microenvironment and Tumor-Targeted Therapy
Cancer tissue or cancer cells do not exist in isolation, but start life within the microenvironment called tumor microenvironment (TME). The...
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Recent advances and applications of peptide–agent conjugates for targeting tumor cells
BackgroundCancer, being a complex disease, presents a major challenge for the scientific and medical communities. Peptide therapeutics have played a...
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Synthesis and evaluation of tumor-homing peptides for targeting prostate cancer
High toxicity caused by chemotherapeutic drugs and the acquisition of drug resistance by cancer cells are the major drawbacks in cancer therapy. A...
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Combination of STING agonist with anti-vascular RGD-(KLAKLAK)2 peptide as a novel anti-tumor therapy
Immunotherapy is one of the most promising anti-cancer treatment. It involves activating the host's own immune system to eliminate cancer cells....
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Enhancing mesenchymal stem cell survival and homing capability to improve cell engraftment efficacy for liver diseases
Although mesenchymal stem cell (MSC) transplantation provides an alternative strategy for end-stage liver disease (ESLD), further widespread...
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Homing Peptides for Cancer Therapy
Tumor-homing peptides are widely used for improving tumor selectivity of anticancer drugs and imaging agents. The goal is to increase tumor uptake...
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Attenuation of osteoarthritis progression via locoregional delivery of Klotho-expressing plasmid DNA and Tanshinon IIA through a stem cell-homing hydrogel
BackgroundOsteoarthritis (OA) is an aging-related degenerative joint disorder marked by joint discomfort and rigidity. Senescent chondrocytes release...
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A quick and innovative pipeline for producing chondrocyte-homing peptide-modified extracellular vesicles by three-dimensional dynamic culture of hADSCs spheroids to modulate the fate of remaining ear chondrocytes in the M1 macrophage-infiltrated microenvironment
BackgroundExtracellular vesicles (EVs) derived from human adipose-derived mesenchymal stem cells (hADSCs) have shown great therapeutic potential in...
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Formulated nano-liposomes for reversal of cisplatin resistance in NSCLC with nucleus-targeting peptide
Cell membrane-engineered nano-delivery systems have evolved as a promising strategy to enhance drug bioavailability, offering an alternative for...
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Natural killer cell homing and trafficking in tissues and tumors: from biology to application
Natural killer (NK) cells, a subgroup of innate lymphoid cells, act as the first line of defense against cancer. Although some evidence shows that NK...
