Search
Search Results
-
Homology Modeling of Transporter Proteins
Membrane transporter proteins are divided into channels/pores and carriers and constitute protein families of physiological and pharmacological...
-
Dopamine Transporter Deficiency Syndrome (DTDS)
Dopamine transporter deficiency syndrome (DTDS) associated with SLC6A3 is a complex and unusual form of movement disorder caused by human dopamine...
-
Plasmodium falciparum: Transporter and Drug Target
Malaria will continue to be a concern for public health well into the future, as it is responsible for more than 50 million fatalities annually...
-
Dimerization and antidepressant recognition at noradrenaline transporter
The noradrenaline transporter has a pivotal role in regulating neurotransmitter balance and is crucial for normal physiology and neurobiology
1 ....
-
Discovery and Development of Monoamine Transporter Ligands
Monoamine transporters (MATs) are targets of a wide range of compounds that have been developed as therapeutic treatments for various...
-
Genome-wide identification of nitrate transporter 1/peptide transporter family (NPF) induced by arbuscular mycorrhiza in the maize genome
The Transporter 1/Peptide Transporter Family (NPF) is essential for the uptake and transport of nitrate nitrogen. Significant increases in nitrogen...
-
Glutathione transporter as a target for brain drug delivery
Inability to achieve therapeutic concentrations of a medication in the brain due to the blood brain barrier (BBB) is the major cause of treatment...
-
A new antibiotic traps lipopolysaccharide in its intermembrane transporter
Gram-negative bacteria are extraordinarily difficult to kill because their cytoplasmic membrane is surrounded by an outer membrane that blocks...
-
Generation of a Cell Line Selectively Producing Functionally Active OATP1B1 Transporter
AbstractThe solute carrier organic anion transporter family member, OATP1B1, is one of the most important transporter proteins, which mediate...
-
Cryo-EM structure of the human Asc-1 transporter complex
The Alanine-Serine-Cysteine transporter 1 (Asc-1 or SLC7A10) forms a crucial heterodimeric transporter complex with 4F2hc (SLC3A2) through a covalent...
-
Unearthing FLVCR1a: tracing the path to a vital cellular transporter
The Feline Leukemia Virus Subgroup C Receptor 1a (FLVCR1a) is a member of the SLC49 Major Facilitator Superfamily of transporters. Initially...
-
Design and Experiment of Double Scissor Sugarcane Field Transporter
At present, the sugarcane field transporters used widely in Guangxi, China, have insufficient applicability and efficiency due to the integral...
-
Liganden für Kanäle, Poren und Transporter
Die Zelle ist die kleinste strukturelle und funktionale Einheit aller Lebewesen. Einzeller bestehen nur aus einer einzigen solchen Einheit. Bei...
-
Circular and L50-like leaderless enterocins share a common ABC-transporter immunity gene
Microbes live within complex communities of interacting populations, either free-living in waters and soils or symbionts of animals and plants. Their...
-
The Role of Variability in Monoamine Transporter Genes in Sport Physiology
AbstractMonoamine transporters (MATs) are responsible for the reuptake of dopamine, serotonin, and norepinephrine, modulating concentrations of these...
-
The glucose transporter GLUT12, a new actor in obesity and cancer
Obesity constitutes a global health epidemic which worsens the main leading death causes such as type 2 diabetes, cardiovascular diseases, and...
-
W546 stacking disruption traps the human porphyrin transporter ABCB6 in an outward-facing transient state
Human ATP-binding cassette transporter subfamily B6 (ABCB6) is a mitochondrial ATP-driven pump that translocates porphyrins from the cytoplasm into...
-
Correlating sugar transporter expression and activities to identify transporters for an orphan sugar substrate
AbstractFilamentous fungi like Neurospora crassa are able to take up and metabolize important sugars present, for example, in agricultural and human...
-
Structural insights into human organic cation transporter 1 transport and inhibition
The human organic cation transporter 1 (hOCT1), also known as SLC22A1, is integral to hepatic uptake of structurally diversified endogenous and...
-
Ligand coupling mechanism of the human serotonin transporter differentiates substrates from inhibitors
The presynaptic serotonin transporter (SERT) clears extracellular serotonin following vesicular release to ensure temporal and spatial regulation of...
