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Imaging of aqueous outflow in health and glaucoma. Justifying the re-direction of aqueous
A wave of less invasive surgical options that target or bypass the conventional aqueous outflow system has been incorporated into routine clinical...
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RNA-seq analysis of human trabecular endothelial cells after treatment with timolol maleate
PurposeTimolol maleate (timolol), a β-receptor blocker, reduces intraocular pressure by decreasing aqueous humor production. Timolol reportedly also...
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VEGF-A-induced changes in distal outflow tract structure and function
PurposeTo investigate changes in distal outflow tract vessels caused by VEGF-A and their impact on outflow.
MethodsWe compared VEGF-A perfused...
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iPSCs-Based Therapy for Trabecular Meshwork
The trabecular meshwork (TM) of the eye serves as an essential tissue in controlling aqueous humor (AH) outflow and intraocular pressure (IOP)...
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Role of mechanically-sensitive cation channels Piezo1 and TRPV4 in trabecular meshwork cell mechanotransduction
Glaucoma is one of the leading causes of irreversible blindness in developed countries, and intraocular pressure (IOP) is primary and only treatable...
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Development of Cell Culture Platforms for Study of Trabecular Meshwork Cells and Glaucoma Development
Background:Various cell culture platforms that could display native environmental cue-mimicking stimuli were developed, and effects of environmental...
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Serine to proline mutation at position 341 of MYOC impairs trabecular meshwork function by causing autophagy deregulation
Glaucoma is a highly heritable disease, and myocilin was the first identified causal and most common pathogenic gene in glaucoma. Serine-to-proline...
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Characterization of Trabecular Meshwork Mechanical Property Modulation After Application of Lipids
Treatment of lipids endogenous to the aqueous humor of the eye could serve as a potential therapy to slow the progression of glaucoma. Herein, we...
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Double trouble - dual outflow tract obstruction in congenital heart disease: a case report
BackgroundDouble chambered right ventricle is a rare congenital heart disease that is characterised by the presence of an anomalous muscle bundle...
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Suppression of trabecular meshwork phagocytosis by norepinephrine is associated with nocturnal increase in intraocular pressure in mice
Intraocular pressure (IOP) is an important factor in glaucoma development, which involves aqueous humor (AH) dynamics, with inflow from the ciliary...
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Analysis of Lipid Contents in Human Trabecular Meshwork Cells by Multiple Reaction Monitoring (MRM) Profiling Lipidomics
Lipids are among the major constituents of cells and play many important cellular functions. Lipid levels in the trabecular meshwork (TM) aqueous...
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Association of trabecular meshwork height with steroid-induced ocular hypertension
It is important to identify at-risk patients prior to administering steroid injections to prevent avoidable irreversible blindness inducted by...
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Predictive biomarkers of intra-ocular pressure decrease after cataract surgery associated with trabecular washout in patients with pseudo exfoliative glaucoma
To investigate biomarkers of intra-ocular pressure (IOP) decrease after cataract surgery with trabecular washout in pseudo-exfoliative (PEX)...
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Biomechanical Properties of the Trabecular Meshwork in Aqueous Humor Outflow Resistance
Glaucoma is a multi-factorial disease often associated with elevated intraocular pressure and increased rigidity of the trabecular meshwork (TM)....
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Five-Year Outcomes of Single Trabecular Microbypass Stent (iStent®) Implantation with Phacoemulsification in Korean Patients
IntroductionThis study reports the long-term intraocular pressure (IOP)-lowering efficacy and safety of a single trabecular microbypass stent (iStent
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Detailed 3D micro-modeling of rat aqueous drainage channels based on two-photon imaging: simulating aqueous humor through trabecular meshwork and Schlemm’s canal by two-way fluid structure interaction approach
Elevated intraocular pressure (IOP) appears to have a broader impact on increased resistance to aqueous humor (AH) outflow through the conventional...
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Trabeculopuncture as a predictive test of distal outflow resistance in canal-based surgery
We investigated whether trabeculopuncture (TP) could detect distal outflow resistance to predict the outcome of canal-based glaucoma surgery such as...
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Right Ventricular Outflow Obstructive Lesions with Right-to-Left Shunt
Cyanotic congenital heart lesions associated with right ventricular outflow obstruction is characterized by reduced blood flow to the pulmonary...
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SDPR expression in human trabecular meshwork and its potential role in racial disparities of glaucoma
In order to identify how differential gene expression in the trabecular meshwork (TM) contributes to racial disparities of caveolar protein...
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The effect of uneventful cataract surgery on Schlemm’s canal and the trabecular meshwork in cases with pseudoexfoliation
PurposeTo evaluate the effect of uneventful cataract surgery on Schlemm’s canal (SC) and the trabecular meshwork (TM) in cases with pseudoexfoliation...
