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Effects of CYP2D6 and CYP2C19 genetic polymorphisms and cigarette smoking on the pharmacokinetics of tolperisone
Tolperisone, a muscle relaxant used for post-stroke spasticity, is metabolized to its main metabolite by CYP2D6 and to a lesser extent by CYP2C19 and...
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Effects of CYP2D6*10 allele on the pharmacokinetics of tolperisone
Tolperisone, a muscle relaxant used for post-stroke spasticity, has been reported to have a very wide interindividual pharmacokinetic variability. It...
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Effects of CYP2C19 genetic polymorphism on the pharmacokinetics of tolperisone in healthy subjects
Tolperisone hydrochloride is a centrally-acting muscle relaxant used for relieving spasticities of neurological origin and muscle spasms associated...
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NMR study of the inclusion complexes of β-cyclodextrin with diphenhydramine, clonidine and tolperisone
AbstractForming complexes with β-cyclodextrin can enhance stability, dissolution rate, solubility, and bioavailability of an active pharmaceutical...
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Application of Photogenerated Iodine for Tolperisone Hydrochloride Determination in Tablet Dosage Form
A technique for accelerated tolperisone hydrochloride (TH) determination in tablet dosage form based on titration of the analytical form with a...
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Screen-printed sensors for efficient potentiometric analysis of tolperisone hydrochloride in presence of its co-formulated drugs
Researchers seeking for green chemistry to help safeguard and boost the economy and the environment by discovering unique ways to decrease waste and...
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Oral Spasmolytics
This chapter discusses the various oral medications used and studied for the treatment of spasticity. The more common oral medications currently used... -
Clinical Problems of Drugs Used to Treat Movement Disorders
The term movement disorders describes neurological conditions producing abnormalities of movements. They are associated with the basal ganglia and... -
Clinical Problems of Drugs Used to Treat Movement Disorders
The term movement disorders describes neurological conditions producing abnormalities of movements. They are associated with the basal ganglia and... -
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Deuterated Drugs
A deuterated drug comprises diminutive molecules in which deuterium replaces one or more than one hydrogen atoms of the molecule. As deuterium and...
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Therapeutic effects of eperisone on pulmonary fibrosis via preferential suppression of fibroblast activity
Although the exact pathogenesis of idiopathic pulmonary fibrosis (IPF) is still unknown, the transdifferentiation of fibroblasts into myofibroblasts...
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Nonsurgical Treatment of Discogenic Sciatica
Conservative (nonsurgical) management is typically the first-line therapeutic intervention in the majority of patients with discogenic sciatica as... -
Faster and Dirtier for Russia: The Story of Yuliya Stepanova
Yuliya Stepanova (née Rusanova) is a former international 800 m track runner for Russia, who competed in multiple world-level competitions. During... -
CDCDB: A large and continuously updated drug combination database
In recent years, due to the complementary action of drug combinations over mono-therapy, the multiple-drugs for multiple-targets paradigm has...
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“Platelet-Rich Plasma” epidural injection an emerging strategy in lumbar disc herniation: a Randomized Controlled Trial
BackgroundLumbar herniated disc (HNP) is mainly treated by conservative management. Epidural steroid injection (ESI) has been an option to treat...