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Effects of thienopyridine class antiplatelets on bleeding outcomes following robot-assisted radical prostatectomy
This study aimed to assess the effects of thienopyridine-class antiplatelet agents (including ticlopidine, clopidogrel, and prasugrel) on bleeding...
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Prediction of Drug–Drug Interactions After Esketamine Intranasal Administration Using a Physiologically Based Pharmacokinetic Model
Background and ObjectiveA physiologically based pharmacokinetic (PBPK) modeling approach for esketamine and its metabolite noresketamine after...
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Systemic Barriers and Potential Concerns from Reporting Serious Adverse Drug Reactions
About 1–10% of all serious adverse drug reactionsSerious adverse drug reactions (sADRs) are reported to the Food and Drug Administration (FDA) (...
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Antiplatelet therapy for secondary prevention of lacunar stroke: a systematic review and network meta-analysis
PurposeTo comprehensively compare the efficacy of different antiplatelet therapies for secondary prevention of lacunar stroke (LS).
Methods ...
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Induction of clastogenesis and gene mutations by carbamazepine (at its therapeutically effective serum levels) in mammalian cells and the dependence on human CYP2B6 enzyme activity
Carbamazepine (CBZ, an antiepileptic) is metabolized by multiple CYP enzymes to its epoxide and hydroxides; however, whether it is genotoxic remains...
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Antiplatelet drugs for secondary prevention in patients with ischemic stroke or transient ischemic attack: a systematic review and network meta-analysis
BackgroundAntiplatelet drugs may prevent recurrent ischemic events after ischemic stroke but their relative effectiveness and harms still need to be...
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Effect of anticoagulant/antiplatelet therapy on the development and progression of diabetic retinopathy
BackgroundWe investigated whether antiplatelet/anticoagulant (APAC) therapy can protect patients with type 2 diabetes mellitus (T2DM) from the...
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Antithrombotic Therapy for Heterogeneous Causes of Stroke
Ischemic stroke is a leading cause of death and a primary cause of long-term disability. Patients surviving the initial event are at a high risk of...