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Synthesis of Bioactive Thioxoimidazolidinones, Oxazolidinones, Thioxothiazolidinones, Thiazolidinediones
The unique biological features of five-membered heterocycles, which particularly possess exocyclic double-bonded atoms such as sulfur and oxygen,...
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Gastroprotective effect of rhodanine and 2,4-thiazolidinediones scaffolds in rat stomachs by contribution of anti-apoptotic (BCL-2) and tumor suppressor (P53) proteins
In recent times, the methods used to evaluate gastric ulcer healing worldwide have been based on visual examinations and estimating ulcer dimensions...
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Thiazolidinediones (TZDs)
Insulin resistance is essential pathophysiology of type 2 diabetes mellitus (T2DM). And unsuppressed lipolysis in adipocytes with increased free...
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Synthesis, molecular docking, and in vivo antidiabetic evaluation of new benzylidene-2,4-thiazolidinediones as partial PPAR-γ agonists
Peroxisome proliferator-activated receptor-γ (PPAR-γ) partial agonists or antagonists, also termed as selective PPAR-γ modulators, are more...
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Comparative efficacy of oral insulin sensitizers metformin, thiazolidinediones, inositol, and berberine in improving endocrine and metabolic profiles in women with PCOS: a network meta-analysis
BackgroundMultiple oral insulin-sensitizing agents, such as metformin, thiazolidinediones, inositols, and berberine, have been proven safe and...
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Association of the Pro12Ala gene polymorphism with treatment response to thiazolidinediones in patients with type 2 diabetes: a meta-analysis
Background/purpose of the studyWith the conflicting results on available studies regarding the association of the Pro12Ala polymorphism with the...
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The Effect of Thiazolidinediones in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomised Controlled Trials
IntroductionPolycystic ovary syndrome (PCOS) is a complex endocrine condition affecting women of reproductive age. It is characterised by insulin...
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Sodium-glucose cotransporter protein-2 inhibitors and glucagon-like peptide-1 receptor agonists versus thiazolidinediones for non-alcoholic fatty liver disease: A network meta-analysis
AimsNon-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disorders worldwide. Some hypoglycemic drugs can improve NAFLD....
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Synthesis, Characterization, and Antimicrobial Evaluation of Some Novel 3′-(6-(Substituted Phenyl)-4-Phenyl-6H-1,3-Thiazine-2-yl)Spiro[Indoline-3,3′-Isothiazolidine]-2,4′-Dione Derivatives
Thiazolidinediones (TZDs) are the vital component of a number of pharmaceuticals and biologically active compounds. Owing to the diversified...
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Combination therapies with thiazolidinediones are associated with a lower risk of acute exacerbations in new-onset COPD patients with advanced diabetic mellitus: a cohort-based case–control study
BackgroundThe effects of oral antihyperglycaemic drugs (OADs) for type 2 diabetes mellitus (T2DM) on the outcomes of co-existing chronic obstructive...
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Thiazolidinediones: the Forgotten Diabetes Medications
Purpose of ReviewThiazolidinediones (TZDs) are the only pharmacologic agents that specifically treat insulin resistance. The beneficial effects of...
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Synthesis of novel 1,2,3-triazoles bearing 2,4 thiazolidinediones conjugates and their biological evaluation
Searching for new active molecules against M. Bovis BCG and Mycobacterium tuberculosis (MTB) H37Ra , a focused of 1,2,3-triazoles-incorporated 2,4...
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Repurposing antidiabetic drugs for rheumatoid arthritis: results from a two-sample Mendelian randomization study
Despite increasing therapeutic options to treat rheumatoid arthritis (RA), many patients fail to reach treatment targets. The use of antidiabetic...
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In silico Studies on PPARγ Agonistic Heterocyclic Systems
Several heterocyclic derivatives like oxazolidinediones, thiazolidinediones, tetarazoles, phenoxazines, etc. are being developed for the treatment...
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Efficacy of Regimens in the Treatment of Latent Autoimmune Diabetes in Adults: A Network Meta-analysis
IntroductionLatent autoimmune diabetes in adults (LADA) is a highly heterogeneous autoimmune condition with clinical and genetic characteristics that...
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Use of Non-insulin Agents for Hyperglycemia Management in Hospitalized Patients
Hyperglycemia in hospitalized patients predicts increased morbidity and mortality. Basal-bolus insulin represents the primary recommended therapy for...
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Effects of first-line diabetes therapy with biguanides, sulphonylurea and thiazolidinediones on the differentiation, proliferation and apoptosis of islet cell populations
AimsMetformin, rosiglitazone and sulfonylureas enhance either insulin action or secretion and thus have been used extensively as early stage...
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The causal relationship between anti-diabetic drugs and gastrointestinal disorders: a drug-targeted mendelian randomization study
BackgroundThe incidence of diabetic gastrointestinal diseases is increasing year by year. This study aimed to investigate the causal relationship...
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Genotype-stratified treatment for monogenic insulin resistance: a systematic review
BackgroundMonogenic insulin resistance (IR) includes lipodystrophy and disorders of insulin signalling. We sought to assess the effects of...
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A consensus statement from the Japan Diabetes Society (JDS): a proposed algorithm for pharmacotherapy in people with type 2 diabetes—2nd Edition (English version)
The Japan Diabetes Society (JDS) adopted a swee** decision to release consensus statements on relevant issues in diabetes management that require...
