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Biological Markers of Therapeutic Response in Prostate Cancer
The remarkable variability in clinical behaviour of prostate cancer necessitates an individualized approach to therapy. The reliance on conventional...
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The relationship between imaging features, therapeutic response, and overall survival in pediatric diffuse intrinsic pontine glioma
We aimed to evaluate the relationship between imaging features, therapeutic responses (comparative cross-product and volumetric measurements), and...
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Therapeutic targets and biomarkers of tumor immunotherapy: response versus non-response
Cancers are highly complex diseases that are characterized by not only the overgrowth of malignant cells but also an altered immune response. The...
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Clinical characteristics and therapeutic response of differentiated thyroid carcinoma with obesity and diabetes
BackgroundThe effects of obesity and diabetes on the clinical outcomes of differentiated thyroid cancer (DTC) remain unclear.
Objectives ...
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Emerging mechanisms of the unfolded protein response in therapeutic resistance: from chemotherapy to Immunotherapy
The accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER) causes ER stress and activates the unfolded protein response...
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Crosstalk with lung fibroblasts shapes the growth and therapeutic response of mesothelioma cells
Mesothelioma is an aggressive cancer of the mesothelial layer associated with an extensive fibrotic response. The latter is in large part mediated by...
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Histopathology images-based deep learning prediction of prognosis and therapeutic response in small cell lung cancer
Small cell lung cancer (SCLC) is a highly aggressive subtype of lung cancer characterized by rapid tumor growth and early metastasis. Accurate...
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Reclassification of therapeutic response of unresectable hepatocellular carcinoma to anti-angiogenic therapy and immunotherapy using alpha RECIST
ObjectivesTo assess the therapeutic response of HCC to antiangiogenic therapy plus immunotherapy by integrating RECIST 1.1 and alpha-fetoprotein...
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Dynamic blood flow imaging with 99mTc-hydroxymethylene diphosphonate as a therapeutic response marker in patients with Raynaud’s phenomenon
We evaluated the predictive value of dynamic blood flow scintigraphy with 99m Tc-HDP (hydroxymethylene diphosphonate) for therapeutic response in...
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Changes in therapeutic response, ocular manifestations of Graves’ orbitopathy and quality of life during the first year after orbital radiotherapy
PurposeThe aim of our study was to assess the changes in the therapeutic response, ocular manifestations of GO and quality of life during the first...
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TXNIP: A key protein in the cellular stress response pathway and a potential therapeutic target
Thioredoxin-interacting protein (TXNIP), which is also known as thioredoxin-binding protein 2 (TBP2), directly interacts with the major antioxidant...
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Imatinib pharmacokinetics and creatine kinase levels in chronic myeloid leukemia patients: implications for therapeutic response and monitoring
BackgroundImatinib treatment for certain cancers can lead to elevated creatine kinase (CK) levels, potentially indicating muscle injury, and ongoing...
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Inflammatory cell death, PANoptosis, screen identifies host factors in coronavirus innate immune response as therapeutic targets
The COVID-19 pandemic, caused by the β-coronavirus (β-CoV) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), continues to cause...
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Serum uric acid predicts therapeutic response to midodrine hydrochloride in children with vasovagal syncope: a pilot study
AbstractSerum uric acid (UA) level has been proven to be related to several cardiovascular and metabolic diseases. In the present study, we examined...
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A weakly supervised deep learning approach for guiding ovarian cancer treatment in prognosis: gigapixel histopathology analysis for personalized therapeutic response
Patients battling with ovarian cancer (OC) often face a formidable prognosis, further complicated by the variability in their response to treatment....
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Targeting CD73 increases therapeutic response to immunogenic chemotherapy by promoting dendritic cell maturation
The CD39-CD73–adenosinergic pathway converts adenosine triphosphate (ATP) to adenosine for inhibiting anti-tumor immune responses. Therefore,...
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Immunogenicity of Therapeutic Proteins
Therapeutic proteins are potent medications that have shown substantial promise in treating a wide range of illnesses and conditions. Immunogenicity...
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Immunogenicity of Therapeutic Proteins
The use of proteins for medical applications has revolutionized therapies of many diseases/disorders that were often incurable with small-molecule...
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Effect of direct therapeutic ultrasound exposure of ovaries on histopathology, inflammatory response, and oxidative stress in dogs
BackgroundThis research was designed to evaluate the effects of therapeutic ultrasound waves on ovarian germinal tissue and inflammatory cytokines...
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Pharmacological interaction and immune response of purinergic receptors in therapeutic modulation
Nucleosides and purine nucleotides serve as transmitter and modulator agents that extend their functions beyond the cell. In this context, purinergic...
