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Double knock-in pig models with elements of binary Tet-On and phiC31 integrase systems for controllable and switchable gene expression
Inducible expression systems are indispensable for precise regulation and in-depth analysis of biological process. Binary Tet-On system has been...
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The Usefulness of AirSeal™ Intelligent Flow System in Gas Insufflation Total Endoscopic Thyroidectomy
Total endoscopic thyroidectomy (TET) using low CO 2 insufflation provides cosmetic advantage, excellent working space and visibility. On the contrary,...
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Functional and phylogenetic analysis of TetX variants to design a new classification system
Recently, many TetX variants such as Tet(X3~14) were reported to confer resistance to tigecycline which is a last-resort antibiotic used to treat...
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Real-Time Plasma Magnetic Control System with Equilibrium Reconstruction Algorithm in the Feedback for the Globus-M2 Tokamak
AbstractTo control the plasma shape during a tokamak discharge, it is necessary to calculate the plasma shape in real-time. The rate requirements for...
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Optimisation of Tet-On inducible systems for Slee** Beauty-based chimeric antigen receptor (CAR) applications
Regulated expression of genetic elements that either encode polypeptides or various types of functional RNA is a fundamental goal for gene therapy....
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Establishing a one-step marker-free CRISPR/Cas9 system for industrial Aspergillus niger using counter-selectable marker Ang-ace2
ObjectivesTo develop a one-step, marker-free CRISPR/Cas9 system for highly efficient genome editing in industrial Aspergillus niger , with a short...
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Research on suppressing radiation noise of plate inside acoustic cavity based on targeted energy transfer of nonlinear energy sink
The membrane as a nonlinear energy sink (NES) can suppress the noise inside acoustic cavities. In this paper, aiming at the radiated noise of the...
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Doxycycline Sensitive Two-Promoter Integrator Based on the TET-ON 3G Transactivator
AbstractA synthetic genetic chain was created—a two-promoter integrator, the activity of the output signal of which is high only with the high...
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Tetrandrine Alleviates Silica-induced Pulmonary Fibrosis Through PI3K/AKT Pathway: Network Pharmacology Investigation and Experimental Validation
Tetrandrine (TET) is a bisbenzylisoquinoline alkaloid derived from Stephania tetrandra S. Moor, known for its potential use in attenuating the...
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An improved Tet-on system in microRNA overexpression and CRISPR/Cas9-mediated gene editing
BackgroundTetracycline (Tet)-regulated expression system has become a widely applied tool to control gene activity. This study aimed to improve the...
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Development and evaluation of rapid and accurate one-tube RPA-CRISPR-Cas12b-based detection of mcr-1 and tet(X4)
AbstractThe emergence and quick spread of the plasmid-mediated tigecycline resistance gene tet (X4) and colistin resistance gene mcr-1 have posed a...
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Optimized Doxycycline-Inducible Gene Expression System for Genetic Programming of Tumor-Targeting Bacteria
PurposeIn the programming of tumor-targeting bacteria, various therapeutic or reporter genes are expressed by different gene-triggering strategies....
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Potent synergistic efficacy of 2-methoxy-1,4-naphthoquinone derived from quinones against drug-resistant bacteria
The emergence and worldwide dissemination of mobile tigecycline resistance genes tet (X3)/ tet (X4) posed an enormous threat to the public health....
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Detection and genomic characterization of Klebsiella pneumoniae and Escherichia coli harboring tet(X4) in black kites (Milvus migrans) in Pakistan
The emergence of plasmid-mediated tigecycline resistance gene tet (X4) among clinically relevant bacteria has promoted significant concerns, as...
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Tetrandrine Represses Inflammation and Attenuates Osteoarthritis by Selective Inhibition of COX-2
ObjectiveThere is a lack of effective and long-term safe drugs for the treatment of osteoarthritis (OA). Tetrandrine (Tet) has been approved and used...
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Sequencing analysis of tigecycline resistance among tigecycline non-susceptible in three species of G-ve bacteria isolated from clinical specimens in Baghdad
BackgroundRecent emergence of high-level tigecycline resistance is mediated by tet (X) genes in Gram-negative bacteria, which undoubtedly constitutes...
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Association between arterial stiffness and autonomic dysfunction in participants underwent treadmill exercise testing: a cross-sectional analysis
Data on the impact of arterial stiffness on autonomic function are limited. We sought to investigate whether heart rate recovery (HRR), a predictor...
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A (Traditional Chinese Medicine) TCM-Inspired Doxorubicin Resistance Reversing Strategy: Preparation, Characterization, and Application of a Co-loaded pH-Sensitive Liposome
In this study, nano-strategy for combined medication of active compounds from traditional Chinese medicine herbs was proposed to achieve the...
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A ratiometric fluorescence sensor for tetracycline detection based on two fluorophores derived from Partridge tea
Blue fluorescent carbon dots (PCDs) were prepared by hydrothermal method with Partridge tea. The ethanol extract of Partridge tea (PEE) was found to...
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Mechanism of antibiotic resistance development in an activated sludge system under tetracycline pressure
The mechanism of antibiotic resistance (AR) development in an activated sludge system under tetracycline (TC) pressure was discussed and analyzed....
