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Low TYROBP expression predicts poor prognosis in multiple myeloma
BackgroundMultiple myeloma (MM) is the second most common refractory hematologic cancer. Searching for new targets and prognostic markers for MM is...
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TYROBP/DAP12 knockout in Huntington’s disease Q175 mice cell-autonomously decreases microglial expression of disease-associated genes and non-cell-autonomously mitigates astrogliosis and motor deterioration
IntroductionHuntington’s disease (HD) is a fatal neurodegenerative disorder caused by an expansion of the CAG trinucleotide repeat in the Huntingtin...
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Microglial TYROBP/DAP12 in Alzheimer’s disease: Transduction of physiological and pathological signals across TREM2
TYROBP (also known as DAP12 or KARAP) is a transmembrane adaptor protein initially described as a receptor-activating subunit component of natural...
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MMP9 and TYROBP affect the survival of circulating tumor cells in clear cell renal cell carcinoma by adapting to tumor immune microenvironment
Circulating tumor cells (CTCs) play a key role in tumor metastasis. CTCs have altered gene expression and can survive in the bloodstream. Finding the...
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The role of SPI1-TYROBP-FCER1G network in oncogenesis and prognosis of osteosarcoma, and its association with immune infiltration
Osteosarcoma is an aggressive malignant bone sarcoma worldwide. A causal gene network with specific functions underlying both the development and...
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Elevated TYROBP expression predicts poor prognosis and high tumor immune infiltration in patients with low-grade glioma
BackgroundTyrosine protein tyrosine kinase binding protein (TYROBP) binds non-covalently to activated receptors on the surface of various immune...
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TYROBP, TLR4 and ITGAM regulated macrophages polarization and immune checkpoints expression in osteosarcoma
We established a relationship among the immune-related genes, tumor-infiltrating immune cells (TIICs), and immune checkpoints in patients with...
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Identification of TYROBP and FCER1G as Key Genes with Prognostic Value in Clear Cell Renal Cell Carcinoma by Bioinformatics Analysis
The involvement of aberrantly expressed genes in the pathogenesis and progression of various human malignancies has been widely reported, including...
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Novel biomarkers identified by weighted gene co-expression network analysis for atherosclerosis
BackgroundThis study aimed to screen out the potential diagnostic biomarkers for atherosclerosis (AS).
MethodsWe downloaded the gene expression...
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Identification and validation of potential common biomarkers for papillary thyroid carcinoma and Hashimoto’s thyroiditis through bioinformatics analysis and machine learning
There is a growing body of evidence suggesting that Hashimoto’s thyroiditis (HT) may contribute to an increased risk of papillary thyroid carcinoma...
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Transcriptomics and Metabolomics Unveil the Neuroprotection Mechanism of AnGong NiuHuang (AGNH) Pill Against Ischaemic Stroke Injury
As a famous prescription in China, AnGong NiuHuang (AGNH) pill exerts good neuroprotection for ischaemic stroke (IS), but its mechanism is still...
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Identifying potential biomarkers for the diagnosis and treatment of IgA nephropathy based on bioinformatics analysis
BackgroundIgA nephropathy (IgAN) has become the leading cause of end-stage renal disease in young adults. Nevertheless, the current diagnosis...
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Title: Bioinformatic Identification of Genes Involved in Diabetic Nephropathy Fibrosis and their Clinical Relevance
Tubulointerstitial fibrosis is an important pathological feature of diabetic nephropathy that is associated with impaired renal function. However,...
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Identification of potential diagnostic biomarkers for tenosynovial giant cell tumour by integrating microarray and single-cell RNA sequencing data
PurposeTenosynovial giant cell tumour (TGCT) is a benign hyperplastic and inflammatory disease of the joint synovium or tendon sheaths, which may be...
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Neoadjuvant camrelizumab (an anti-PD-1 antibody) plus chemotherapy or apatinib (a VEGFR-2 inhibitor) for initially unresectable stage II–III non-small-cell lung cancer: a multicentre, two-arm, phase 2 exploratory study
This multicentre, two-arm, phase 2 study aimed to explore the efficacy and safety of neoadjuvant camrelizumab plus chemotherapy or apatinib in...
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Identification of important genes related to HVSMC proliferation and migration in graft restenosis based on WGCNA
The great saphenous vein is the most commonly used vessel for coronary artery bypass grafting (CABG), but its use has been associated with a high...
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Screening and identification of potential key biomarkers for glucocorticoid-induced osteonecrosis of the femoral head
BackgroundGlucocorticoid-induced osteonecrosis of the femoral head (GIONFH) is a common disease in osteoarticular surgery, with a high disability...
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Bronchial epithelial transcriptomics and experimental validation reveal asthma severity-related neutrophilc signatures and potential treatments
Airway epithelial transcriptome analysis of asthma patients with different severity was used to disentangle the immune infiltration mechanisms...
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Identification of shared pathogenetic mechanisms between COVID-19 and IC through bioinformatics and system biology
COVID-19 increased global mortality in 2019. Cystitis became a contributing factor in SARS-CoV-2 and COVID-19 complications. The complex molecular...
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Identification and validation of glomerulotubular crosstalk genes mediating IgA nephropathy by integrated bioinformatics
BackgroundIgA nephropathy (IgAN), which has been reported as the most prevalent glomerulonephritis globally, is the major contributor to end-stage...
