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1. LncRNA TUG1 mediates microglial inflammatory activation by regulating glucose metabolic reprogramming

   Microglia are natural immune cells in the central nervous system, and the activation of microglia is accompanied by a reprogramming of glucose...

   Chunxiang He, Ze Li, ... Shaowu Cheng in Scientific Reports

   Article Open access 27 May 2024
   

2. LncRNA Tug1 relieves the steatosis of SelenoF-knockout hepatocytes via sponging miR-1934-3p

   Metabolic dysfunction associated with fatty liver disease (MAFLD), always accompanied by disturbance of glucose and lipid metabolism, is becoming the...

   Wei Wang, Zhiruo Miao, ... Shiwen Xu in Cell Biology and Toxicology

   Article 18 September 2023
   

3. TUG1-mediated R-loop resolution at microsatellite loci as a prerequisite for cancer cell proliferation

   Oncogene-induced DNA replication stress (RS) and consequent pathogenic R-loop formation are known to impede S phase progression. Nonetheless, cancer...

   Miho M. Suzuki, Kenta Iijima, ... Yutaka Kondo in Nature Communications

   Article Open access 22 August 2023
   

4. CHI3L1 promotes myocardial fibrosis via regulating lncRNA TUG1/miR-495-3p/ETS1 axis

   Abnormal levels of CHI3L1 and lnc TUG1 are often associated with myocardial fibrosis, and their specific expressions may be closely related to the...

   Yunpeng Sun, Xue Shan, ... Dashi Ma in Apoptosis

   Article 07 June 2023
   

5. Long Noncoding RNAs MEG3, TUG1, and hsa-miR-21-3p Are Potential Diagnostic Biomarkers for Coronary Artery Disease

   Abstract

   Peripheral blood biomarkers are of particular importance to diagnose certain diseases including coronary artery disease (CAD) due to their...

   M. Abdelgawad, H. Y. Abdallah, ... A. E. Ahmed in Molecular Biology

   Article 07 December 2023
   

6. METTL14 promotes the development of diabetic kidney disease by regulating m⁶A modification of TUG1

   Background

   Diabetic kidney disease (DKD) is one of the most common diabetic complications. Endoplasmic reticulum stress (ERS) is an important step for...

   Yingying Zheng, Zhengjun Zhang, ... Shaoqiang Wang in Acta Diabetologica

   Article 10 July 2023
   

7. Long noncoding RNA TUG1 induces angiogenesis of endothelial progenitor cells and dissolution of deep vein thrombosis

   Objective

   Long non-coding RNA (lncRNA) essentially controls many physiological and pathological processes of deep vein thrombosis (DVT). Based on...

   Ya** Feng, Bo Lei, ... Fuxian Zhang in Thrombosis Journal

   Article Open access 26 September 2022
   

8. LncRNA TUG1 Promoted Stabilization of BAG5 by Binding DDX3X to Exacerbate Ketamine-Induced Neurotoxicity

   As a clinically widely used anesthetic, ketamine (KET) has been reported to cause neurotoxicity in patients. Our work aimed to probe the function of...

   Xue Lei, **angFei Fang, ... Huan Liu in Neurotoxicity Research

   Article 24 September 2022
   

9. Diagnostic and Prognostic Value of Deregulated Circulating Long Non-coding RNA TUG1 in Elderly Patients with Severe Pneumonia

   To investigate the expression pattern of long non-coding RNA TUG1 in elderly patients with severe community-acquired pneumonia (sCAP) and evaluate...

   Kai Gong, Jiao Xu, Jianlei Tang in Inflammation

   Article 15 September 2022
   

10. The interaction between MALAT1 and TUG1 with dietary fatty acid quality indices on visceral adiposity index and body adiposity index

    We aimed to investigate the interaction between the transcript levels of taurine-upregulated gene 1 (TUG1) and metastasis-associated lung...

    Niloufar Rasaei, Fatemeh Gholami, ... Khadijeh Mirzaei in Scientific Reports

    Article Open access 02 January 2024

11. The pathogenic roles of lncRNA-Taurine upregulated 1 (TUG1) in colorectal cancer

    Colorectal cancer (CRC) is a gastrointestinal tumor that develops from the colon, rectum, or appendix. The prognosis of CRC patients especially those...

    Shirin Azizidoost, Ava Nasrolahi, ... Maryam Farzaneh in Cancer Cell International

    Article Open access 04 November 2022
    

12. Photobiomodulation promotes spinal cord injury repair by inhibiting macrophage polarization through lncRNA TUG1-miR-1192/TLR3 axis

    Background

    Secondary spinal cord injury (SCI) often causes the aggravation of inflammatory reaction and nerve injury, which affects the recovery of...

    Cheng Ju, Yangguang Ma, ... Zhe Wang in Cellular & Molecular Biology Letters

    Article Open access 19 January 2023
    

13. Interfering TUG1 Attenuates Cerebrovascular Endothelial Apoptosis and Inflammatory injury After Cerebral Ischemia/Reperfusion via TUG1/miR-410/FOXO3 ceRNA Axis

    Background Emerging studies illustrate that long non-coding RNA TUG1 (TUG1) participates in neuron death after ischemia. However, the role of TUG1...

    Zhirong He, Yanyan Zhao, ... Fen Lu in Neurotoxicity Research

    Article 01 December 2021
    

14. Anti-angiogenic effect of exo-LncRNA TUG1 in myocardial infarction and modulation by remote ischemic conditioning

    The successful use of exosomes in therapy after myocardial infarction depends on an improved understanding of their role in cardiac signaling and...

    Yini Dang, Wenjie Hua, ... Yu Zheng in Basic Research in Cardiology

    Article 12 January 2023
    

15. SP1-mediated up-regulation of lncRNA TUG1 underlines an oncogenic property in colorectal cancer

    The long non-coding RNA (lncRNA) taurine up-regulated gene 1 (TUG1) acts as tumor-promoting factor in colorectal cancer (CRC). We aimed to elucidate...

    Wei Liu, ** Meng, ... **aoxia Li in Cell Death & Disease

    Article Open access 04 May 2022
    

16. Long non-coding RNA Tug1 modulates mitochondrial and myogenic responses to exercise in skeletal muscle

    Background

    Mitochondria have an essential role in regulating metabolism and integrate environmental and physiological signals to affect processes such...

    Adam J. Trewin, Jessica Silver, ... Séverine Lamon in BMC Biology

    Article Open access 18 July 2022
    

17. Long non-coding RNAs TUG1 and MEG3 in patients with type 2 diabetes and their association with endoplasmic reticulum stress markers

    Background

    Long non-coding RNAs (lncRNAs), including taurine upregulated gene 1 (TUG1), metastasis-associated lung adenocarcinoma transcript 1...

    N. Heydari, R. Sharifi, ... M. Nourbakhsh in Journal of Endocrinological Investigation

    Article 20 January 2023
    

18. LncRNA TUG1 compromised neuronal mitophagy in cerebral ischemia/reperfusion injury by targeting sirtuin 1

    Background

    Mitophagy protects against cerebral ischemia/reperfusion (CI/R)–induced neuronal apoptosis via mitochondrial clearance. Although...

    Long-xing Xue, Song-feng Chen, ... Hong-bo Liu in Cell Biology and Toxicology

    Article 28 March 2022
    

19. LncRNA Tug1 Contributes Post-stroke NLRP3 Inflammasome-Dependent Pyroptosis via miR-145a-5p/Tlr4 Axis

    Pyroptosis, a type of programmed cell death illuminated by inflammasomes and active caspases, is implicated in post-stroke inflammation. Our previous...

    Meiling Yao, Ying Luo, ... Jian Yu in Molecular Neurobiology

    Article 22 August 2022
    

20. Hypermethylation in Ovarian Cancer of Long Noncoding RNA Genes: HOTAIR, GAS5, LINC00472, LINC00886, TUG1

    Abstract

    Recently, more and more data have been accumulating indicating the role of long noncoding RNAs (lncRNAs) in the regulation of biological...

    A. M. Burdennyy, S. S. Lukina, ... E. A. Braga in Russian Journal of Genetics

    Article 21 May 2024