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MicroRNA-499-5p inhibits transforming growth factor-β1-induced Smad2 signaling pathway and suppresses fibroblast proliferation and collagen synthesis in rat by targeting TGFβ-R1
BackgroundAtrial fibrosis has been recognized as a typical pathological change in atrial fibrillation. Although present evidence suggests that...
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MicroRNA‑331 inhibits isoproterenol‑induced expression of profibrotic genes in cardiac myofibroblasts via the TGFβ/smad3 signaling pathway
Cardiac fibrosis in the failing heart is modulated by activated myofibroblasts, and is a pathology marked by their deposition of extracellular matrix...
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Cabozantinib with or without Panitumumab for RAS wild-type metastatic colorectal cancer: impact of MET amplification on clinical outcomes and circulating biomarkers
PurposeAcquired resistance to EGFR inhibitors in metastatic colorectal cancer (mCRC) remains a hurdle for effective treatment. MET amplification has...
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New insights into macrophage polarization and its prognostic role in patients with colorectal cancer liver metastasis
BackgroundAs liver metastasis is the most common cause of mortality in patients with colorectal cancer, studying colorectal cancer liver metastasis...
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Inducible TgfbR1 and Pten deletion in a model of tongue carcinogenesis and chemoprevention
Head and neck squamous cell carcinoma (HNSCC) is a significant public health problem, with a need for novel approaches to chemoprevention and...
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Deciphering the immune reaction leading to spontaneous melanoma regression: initial role of MHCII+ CD163− macrophages
The human cutaneous metastatic melanoma is the deadliest skin cancer. Partial, or less frequently complete spontaneous regressions could be observed,...
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Phenolic acids and a static magnetic field change the expression of transforming growth factor β isoforms in amelanotic melanoma cells
BackgroundMelanoma is an aggressive type of cancer that can metastasize to numerous other organs. TGFβ is one of the key signaling pathways in...
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TGFβ signalling pathway impacts brain metastases profiles in locally advanced colorectal cancer
RationaleColorectal Cancer (CRC) represents the third most common type of cancer in Germany and the second most common cancer-related cause of death...
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Diabetic microenvironment deteriorates the regenerative capacities of adipose mesenchymal stromal cells
BackgroundType 2 diabetes is an endocrine disorder characterized by compromised insulin sensitivity that eventually leads to overt disease. Adipose...
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Generation of locus coeruleus norepinephrine neurons from human pluripotent stem cells
Central norepinephrine (NE) neurons, located mainly in the locus coeruleus (LC), are implicated in diverse psychiatric and neurodegenerative diseases...
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Non-Coding Ribonucleic Acids as Diagnostic and Therapeutic Targets in Cardiac Fibrosis
Purpose of ReviewCardiac fibrosis is a crucial juncture following cardiac injury and a precursor for many clinical heart disease manifestations....
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Application of the Human Amniotic Membrane as an Adjuvant Therapy for the Treatment of Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related morbidity and mortality worldwide. Current therapeutic approaches...
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Downregulation of Elovl5 promotes breast cancer metastasis through a lipid-droplet accumulation-mediated induction of TGF-β receptors
Metastatic breast cancer cannot be cured, and alteration of fatty acid metabolism contributes to tumor progression and metastasis. Here, we were...
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Recruitment of LEF1 by Pontin chromatin modifier amplifies TGFBR2 transcription and activates TGFβ/SMAD signalling during gliomagenesis
Synergies of transcription factors, chromatin modifiers and their target genes are vital for cell fate determination in human cancer. Although the...
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CX3CR1 modulates SLE-associated glomerulonephritis and cardiovascular disease in MRL/lpr mice
ObjectivePatients with systemic lupus erythematosus (SLE) often develop multi-organ damages including heart and kidney complications. We sought to...
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Deciphering tumor immune microenvironment differences between high-grade serous and endometrioid ovarian cancer to investigate their potential in indicating immunotherapy response
BackgroundOvarian cancer is a significant public health concern with a poor prognosis for epithelial ovarian cancer. To explore the potential of...
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Circadian patterns of growth factor receptor-dependent signaling and implications for carcinogenesis
Several different signaling pathways that regulate cell proliferation and differentiation are initiated by binding of ligands to cell-surface and...
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Lung Development
The human capacity to oxygenate and ventilate requires a complex association between the cardiovascular and pulmonary systems. As muscles of...
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Control of TGFβ signalling by ubiquitination independent function of E3 ubiquitin ligase TRIP12
Transforming growth factor β (TGFβ) pathway is a master regulator of cell proliferation, differentiation, and death. Deregulation of TGFβ signalling...
