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Analysis of T follicular and T peripheral helper lymphocytes in autoimmune thyroid disease
PurposePeripheral helper T (Tph) cells have an important role in the induction of humoral immune responses and autoantibody production. Accordingly,...
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Genetic Modification of Tumor-Infiltrating Lymphocytes, Peripheral T Cells, and T-Cell Model Cell Lines
Genetic modification of tumor-infiltrating lymphocytes (TILs) or circulating T cells has become an important avenue in cancer therapy. Here we...
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The effect of metformin on senescence of T lymphocytes
BackgroundImmunosenescence occurs as people age, leading to an increased incidence of age-related diseases. The number of senescent T cells also...
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T-cell lymphocytes’ aging clock: telomeres, telomerase and aging
Aging is the decline of physiological capabilities required for life maintenance and reproduction over time. The human immune cells, including...
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Predominance of T-bet-positive Th1 cells in infiltrating T-lymphocytes in most of active arteritis lesions of giant cell arteritis
Immunological mechanisms through the activation of CD4-positive T-cells have been assumed to be involved in the pathogenesis of giant cell arteritis...
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Regulated secretion of mutant p53 negatively affects T lymphocytes in the tumor microenvironment
Several studies have demonstrated the role of the oncogenic mutant p53 in promoting tumor progression; however, there is limited information on the...
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Evaluation of Leukocytes, B and T Lymphocytes, and expression of CD200 and CD23 on B lymphocytes in Patients with Atopic Dermatitis on Dupilumab Therapy—Pilot Study
BackgroundThere are a lot of studies that describe the change in quantity of T cells in patients with atopic dermatitis (AD) compared with healthy...
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Detection of Intracellular Complement Activation by Nanoparticles in Human T Lymphocytes
The complement system is complex and includes two main components: the systemic or plasma complement and the so-called intracellular complement or...
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Human T lymphocytes at tumor sites
CD4 + and CD8 + T lymphocytes mediate most of the adaptive immune response against tumors. Naïve T lymphocytes specific for tumor antigens are primed...
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CD20 + T lymphocytes in isolated Hashimoto’s thyroiditis and type 3 autoimmune polyendocrine syndrome: a pilot study
BackgroundCD20 + T cells represent up to 5% of circulating T lymphocytes. These cells have been shown to produce higher levels of IL-17A and IFN-γ...
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T Lymphocytes as Targets for SARS-CoV-2
AbstractDespite numerous data on the absence or weak expression of the main functional receptor of SARS-CoV-2 angiotensin-converting enzyme 2 (ACE2)...
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Loss of Y in regulatory T lymphocytes in the tumor micro-environment of primary colorectal cancers and liver metastases
Male sex is a risk factor for colorectal cancer (CRC) with higher illness burden and earlier onset. Thus, we hypothesized that loss of chromosome Y...
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The interplay between T lymphocytes and macrophages in myocardial ischemia/reperfusion injury
Acute myocardial infarction is one of the most important causes of death in the world, causing a huge health and economic burden to the world. It is...
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Cell softness renders cytotoxic T lymphocytes and T leukemic cells resistant to perforin-mediated killing
Mechanical force contributes to perforin pore formation at immune synapses, thus facilitating the cytotoxic T lymphocytes (CTL)-mediated killing of...
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Altered levels of cytokine, T- and B-lymphocytes, and PD-1 expression rates in drug-naïve schizophrenia patients with acute phase
Many studies have investigated the changes of immune cells and proinflammatory cytokines in patients with acute schizophrenia, but few studies have...
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Evaluation of changes in exhausted T lymphocytes and miRNAs expression in the different trimesters of pregnancy in pregnant women
BackgroundThroughout the three trimesters of a typical pregnancy, we looked at changes in the expression of miRNAs and exhausted T lymphocytes for...
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A solution for highly efficient electroporation of primary cytotoxic T lymphocytes
BackgroundCytotoxic T lymphocytes (CTLs) are central players in the adaptive immune response. Their functional characterization and clinical research...
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The Role of Recombinant Glycodelin in the Differentiation of Regulatory T-Lymphocytes
AbstractThe effect of recombinant glycodelin (GdA) on the number of T-regulatory lymphocytes (Treg) in a culture of activated CD4 + lymphocytes was...
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The Composition of Micronuclei in T-Lymphocytes in Women Affected by Chronic Radiation Exposure
AbstractWe studied the chromosomal composition of micronuclei the peripheral blood T-lymphocytes of women chronically exposed due to their residence...
