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Ferroptosis related gene signature in T cell-mediated rejection after kidney transplantation
BackgroundT cell-mediated rejection is an important factor affecting early transplant kidney survival. Ferroptosis has been shown to play a...
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Genome-wide association study biomarkers in T-cell mediated rejection: selective effect according to the Banff classification
BackgroundA genome-wide association study (GWAS) in kidney transplant recipients reported the association of two polymorphisms located in the PTPRO ...
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Exploring personalized treatment for cardiac graft rejection based on a four-archetype analysis model and bioinformatics analysis
Heart transplantation is the gold standard for treating patients with advanced heart failure. Although improvements in immunosuppressive therapies...
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Immunobiology, Diagnosis, and Treatment of Rejection
Despite significant improvement in pancreas allograft survival, pancreas allograft rejection continues to be a significant clinical problem. The...
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Multiplex gene analysis reveals T-cell and antibody-mediated rejection-specific upregulation of complement in renal transplants
In renal transplantation, complement is involved in ischemia reperfusion injury, graft rejection and dysfunction. However, it is still unclear how...
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IL-6 inhibition prevents costimulation blockade-resistant allograft rejection in T cell-depleted recipients by promoting intragraft immune regulation in mice
The efficacy of costimulation blockade with CTLA4-Ig (belatacept) in transplantation is limited due to T cell-mediated rejection, which also persists...
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Cell-free DNA for the detection of kidney allograft rejection
Donor-derived cell-free DNA (dd-cfDNA) is an emerging noninvasive biomarker that has the potential to detect allograft injury. The capacity of...
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Transcriptional and spatial profiling of the kidney allograft unravels a central role for FcyRIII+ innate immune cells in rejection
Rejection remains the main cause of premature graft loss after kidney transplantation, despite the use of potent immunosuppression. This highlights...
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Interferon-γ and its response are determinants of antibody-mediated rejection and clinical outcomes in patients after renal transplantation
Interferon-γ (IFN-γ) is an important cytokine in tissue homeostasis and immune response, while studies about it in antibody-mediated rejection (ABMR)...
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Acute Vascular Rejection
Acute vascular rejection is a terminology that has undergone significant change over the past three decades. It is characterized by intimal arteritis...
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A case of early recurrent immunoglobulin A nephropathy and T-cell-mediated rejection in a transplant patient with Wiskott–Aldrich syndrome
Wiskott–Aldrich syndrome (WAS) is an X-chromosome recessive immunodeficiency disease characterized by the triad of thrombocytopenia, eczema, and...
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Impact of ABO incompatibility and early antibody-mediated rejection on chronic antibody-mediated rejection in kidney transplant patients
IntroductionEarly antibody-mediated rejection has been reported to increase chronic antibody-mediated rejection and decrease graft survival in kidney...
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The Biology and Molecular Basis of Organ Transplant Rejection
Allograft rejection is defined as tissue injury in a transplanted allogeneic organ produced by the effector mechanisms of the adaptive alloimmune...
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Rejection markers in kidney transplantation: do new technologies help children?
Recent insights in allorecognition and graft rejection mechanisms revealed a more complex picture than originally considered, involving multiple...
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Rejection Challenges: Diagnosis and Management
This chapter proposes a summary of the current understanding of kidney allograft rejection, evolving from a traditional conceptualization of discrete...
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Renal Transplant Rejection
Once the technical difficulties of surgical implantation were overcome, live donor transplants between HLA-identical twins demonstrated not only that...
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Design, cohort profile and comparison of the KTD-Innov study: a prospective multidimensional biomarker validation study in kidney allograft rejection
There is an unmet need for robust and clinically validated biomarkers of kidney allograft rejection. Here we present the KTD-Innov...
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Rejection and Immunosuppression
Historically, liver graft rejection has raised great interest in the scientific community since it was the major barrier to successful implementation...
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Multidrug resistant 1 (MDR1) C3435T and G2677T gene polymorphism: impact on the risk of acute rejection in pediatric kidney transplant recipients
BackgroundTacrolimus is the backbone drug in kidney transplantation. Single nucleotide polymorphism of Multidrug resistant 1 gene can affect...
