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1. Machine learning-identified stemness features and constructed stemness-related subtype with prognosis, chemotherapy, and immunotherapy responses for non-small cell lung cancer patients

   Aim

   This study aimed to explore a novel subtype classification method based on the stemness characteristics of patients with non-small cell lung...

   Mingshan Liu, Ruihao Zhou, ... **gtao Zhang in Stem Cell Research & Therapy

   Article Open access 07 September 2023
   

2. Characterization of stemness features and construction of a stemness subtype classifier to predict survival and treatment responses in lung squamous cell carcinoma

   Background

   Cancer stemness has been proven to affect tumorigenesis, metastasis, and drug resistance in various cancers, including lung squamous cell...

   **zhi Lai, **nyi Lin, ... Deqiang Fu in BMC Cancer

   Article Open access 08 June 2023
   

3. Regulation Mechanisms and Maintenance Strategies of Stemness in Mesenchymal Stem Cells

   Stemness pertains to the intrinsic ability of mesenchymal stem cells (MSCs) to undergo self-renewal and differentiate into multiple lineages, while...

   Nizhou Jiang, **liang Tian, ... Hong Wang in Stem Cell Reviews and Reports

   Article 27 November 2023
   

4. CMYC-initiated HNF1A-AS1 overexpression maintains the stemness of gastric cancer cells

   Cancer stem cells (CSCs) are believed to be responsible for cancer metastasis and recurrence due to their self-renewal ability and resistance to...

   Ruinan Zhao, **angyu Guo, ... Haiting Liu in Cell Death & Disease

   Article Open access 23 April 2024
   

5. NELF and PAF1C complexes are core transcriptional machineries controlling colon cancer stemness

   Mutations in APC , found in 80% of colon caner, enhance β-catenin stabilization, which is the initial step of colonic tumorigenesis. However, the core...

   Koji Aoki, Akari Nitta, Ayumi Igarashi in Oncogene

   Article Open access 05 January 2024
   

6. Stemness signature and targeted therapeutic drugs identification for Triple Negative Breast Cancer

   Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer and carries the worst prognosis, characterized by the lack of...

   Samina Gul, Jianyu Pang, ... Wenru Tang in Scientific Data

   Article Open access 20 November 2023
   

7. Molecular Mechanisms of Tumor Cell Stemness Modulation during Formation of Spheroids

   Abstract

   Cancer stem cells (CSCs), their properties and interaction with microenvironment are of interest in modern medicine and biology. There are...

   Aleksei S. Ponomarev, Zarema E. Gilazieva, ... Albert A. Rizvanov in Biochemistry (Moscow)

   Article Open access 20 July 2023

8. Deep dissection of stemness-related hierarchies in hepatocellular carcinoma

   Background

   Increasing evidence suggests that hepatocellular carcinoma (HCC) stem cells (LCSCs) play an essential part in HCC recurrence, metastasis,...

   Rui Liang, Weifeng Hong, ... Guanbin Song in Journal of Translational Medicine

   Article Open access 16 September 2023
   

9. Tumor microenvironment-induced FOXM1 regulates ovarian cancer stemness

   In ovarian tumors, the omental microenvironment profoundly influences the behavior of cancer cells and sustains the acquisition of stem-like traits,...

   Chiara Battistini, Hilary A. Kenny, ... Ugo Cavallaro in Cell Death & Disease

   Article Open access 28 May 2024
   

10. IL20RB signaling enhances stemness and chemotherapy resistance in pancreatic cancer

    Objective

    Pancreatic cancer is an aggressive malignancy with high mortality, and cancer cell stemness and related drug resistance are considered...

    **ao-hui Li, Gui-zhong Huang, ... **ao-jun Lin in Journal of Translational Medicine

    Article Open access 14 December 2023
    

11. p63: a crucial player in epithelial stemness regulation

    Epithelial tissue homeostasis is closely associated with the self-renewal and differentiation behaviors of epithelial stem cells (ESCs). p63, a...

    Yanan Li, Sara Giovannini, ... Francesca Bernassola in Oncogene

    Article Open access 17 October 2023
    

12. Development of a stemness-related prognostic index to provide therapeutic strategies for bladder cancer

    Bladder cancer (BC) is a heterogeneous disease with varying clinical outcomes. Recent evidence suggests that cancer progression involves the...

    Shi Fu, Zhiyong Tan, ... Haifeng Wang in npj Precision Oncology

    Article Open access 20 January 2024
    

13. Targeted silencing of SOCS1 by DNMT1 promotes stemness of human liver cancer stem-like cells

    Background

    Human liver cancer stem-like cells (HLCSLCs) are widely acknowledged as significant factors in the recurrence and eradication of...

    Lei Lou, Tingyun Deng, ... **ang Li in Cancer Cell International

    Article Open access 12 June 2024
    

14. The DUBA-SLC7A11-c-Myc axis is critical for stemness and ferroptosis

    Ferroptosis is characterized by the accumulation of lipid peroxidation as a unique iron-dependent cell death. However, the interplay between stemness...

    Zuli Wang, Lianlian Ouyang, ... Yongguang Tao in Oncogene

    Article 03 August 2023
    

15. USP51 promotes non-small cell lung carcinoma cell stemness by deubiquitinating TWIST1

    Background

    USP51 is a deubiquitinase (DUB), that is involved in diverse cellular processes. Accumulating evidence has demonstrated that USP51...

    ** Chen, Zhongqiu Wu, ... Wenting Li in Journal of Translational Medicine

    Article Open access 08 July 2023
    

16. Identification of stemness-related glycosylation changes in head and neck squamous cell carcinoma

    Background

    Altered glycosylation is a hallmark of cancer associated with therapy resistance and tumor behavior. In this study, we investigated the...

    E Routila, R Mahran, ... J Leivo in BMC Cancer

    Article Open access 10 April 2024
    

17. CDC45 promotes the stemness and metastasis in lung adenocarcinoma by affecting the cell cycle

    Objective

    This study aimed to assess the functions of cell division cycle protein 45 (CDC45) in Non-small cell lung cancer (NSCLC) cancer and its...

    Yafeng Liu, Tao Han, ... Dong Hu in Journal of Translational Medicine

    Article Open access 08 April 2024
    

18. Pancreatic cancer stemness: dynamic status in malignant progression

    Pancreatic cancer (PC) is one of the most aggressive malignancies worldwide. Increasing evidence suggests that the capacity for self-renewal,...

    Yutong Zhao, Cheng Qin, ... Weibin Wang in Journal of Experimental & Clinical Cancer Research

    Article Open access 13 May 2023
    

19. Stemness subtypes in lower-grade glioma with prognostic biomarkers, tumor microenvironment, and treatment response

    Our research endeavors are directed towards unraveling the stem cell characteristics of lower-grade glioma patients, with the ultimate goal of...

    Shengda Ye, Bin Yang, ... Wenyuan Zhao in Scientific Reports

    Article Open access 26 June 2024
    

20. Lysine demethylase LSD1 is associated with stemness in EBV-positive B cell lymphoma

    EBV-infected lymphoma has a poor prognosis and various treatment strategies are being explored. Reports suggesting that B cell lymphoma can be...

    Joo Hyun Kim, Chaehwa Park, Won Seog Kim in Scientific Reports

    Article Open access 21 March 2024