Search
Search Results
-
Spike initiating dynamics at axonal afterpotentials: model-based mechanisms of the recovery cycle
The axons exhibit depolarizing and hyperpolarizing afterpotentials, which result in complicated patterns of recovery cycle and influence the...
-
The impact of spike timing precision and spike emission reliability on decoding accuracy
Precisely timed and reliably emitted spikes are hypothesized to serve multiple functions, including improving the accuracy and reproducibility of...
-
Impact of SARS-CoV-2 spike stability and RBD exposure on antigenicity and immunogenicity
The spike protein (S) of SARS-CoV-2 induces neutralizing antibodies and is the key component of current COVID-19 vaccines. The most efficacious...
-
Deconvolution improves the detection and quantification of spike transmission gain from spike trains
Accurate detection and quantification of spike transmission between neurons is essential for determining neural network mechanisms that govern...
-
Spike synchrony as a measure of Gestalt structure
The function of spike synchrony is debatable: some researchers view it as a mechanism for binding perceptual features, others – as a byproduct of...
-
SARS-CoV-2 spike-specific TFH cells exhibit unique responses in infected and vaccinated individuals
Long-term humoral immunity to SARS-CoV-2 is essential for preventing reinfection. The production of neutralizing antibody (nAb) and B cell...
-
Quantity of IgG response to SARS-CoV-2 spike glycoprotein predicts pulmonary recovery from COVID-19
The CovILD study is a prospective, multicenter, observational cohort study to systematically follow up patients after coronavirus disease-2019...
-
The Effects of Ghrelin on Spike Activity of the Suprachiasmatic Nucleus Neurones of the Rat
AbstractIn one of the most important non-photic mechanisms of the circadian biological clock synchronization of the hypothalamus...
-
Effects of metal corrosion in the pump of a dialysis machine on the sterility of the terminal dialysate by spike-and-recovery testing with bacteria
BackgroundDialysis units have been concerned that the corroded metal parts of pumps used in hemodialysis might not allow sterility of the pump to be...
-
The initial intracranial pressure spike phenomenon
BackgroundElective use of intraparenchymal intracranial pressure (ICP) monitoring is a valuable resource in the investigation of hydrocephalus and...
-
SARS-CoV-2 hijacks a cell damage response, which induces transcription of a more efficient Spike S-acyltransferase
SARS-CoV-2 infection requires Spike protein-mediated fusion between the viral and cellular membranes. The fusogenic activity of Spike depends on its...
-
Effect of Et2Zn on Binding Spike Protein of SARS-Cov-2 and ACE2 from Cell Membrane
AbstractCorona virus’s connection to the cell is through spike protein to ACE2 from cell membrane. This connection was modeled using Density...
-
Prediction of Prospective Mutational Landscape of SARS-CoV-2 Spike ssRNA and Evolutionary Basis of Its Host Interaction
Booster doses are crucial against severe COVID-19, as rapid virus mutations and variant emergence prolong the pandemic crisis. The virus’s quick...
-
SARS-CoV-2 spike protein S1 activates Cx43 hemichannels and disturbs intracellular Ca2+ dynamics
BackgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the ongoing coronavirus disease 2019 (COVID-19). An aspect of high...
-
On Strong Basins of Attractions for Non-convex Sparse Spike Estimation: Upper and Lower Bounds
In this article, we study the size of strong basins of attractions for the non-convex sparse spike estimation problem. We first extend previous...
-
Molecular mimicry of the receptor-binding domain of the SARS-CoV-2 spike protein: from the interaction of spike-specific antibodies with transferrin and lactoferrin to the antiviral effects of human recombinant lactoferrin
The pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection involves dysregulations of iron metabolism, and although...
-
Computational aptamer design for spike glycoprotein (S) (SARS CoV-2) detection with an electrochemical aptasensor
AbstractA new bioinformatic platform (APTERION) was used to design in a short time and with high specificity an aptamer for the detection of the...
-
Differential Cytokine Responses of APOE3 and APOE4 Blood–brain Barrier Cell Types to SARS-CoV-2 Spike Proteins
SARS-CoV-2 spike proteins have been shown to cross the blood–brain barrier (BBB) in mice and affect the integrity of human BBB cell models. However,...
-
Low Energy Response of Spike Train Encoded Data
A low energy response of data encoded from a single time representation into a temporal spike train results in a sparse non-binary digital code...
-
Effectiveness of VSV vectored SARS-CoV-2 spike when administered through intranasal, intramuscular or a combination of both
A critical feature of the VSV vector platform is the ability to pseudotype the virus with different glycoproteins from other viruses, thus altering...
