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Meta-analysis of single-cell and single-nucleus transcriptomics reveals kidney cell type consensus signatures
While the amount of studies involving single-cell or single-nucleus RNA-sequencing technologies grows exponentially within the biomedical research...
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Comparison of cell type distribution between single-cell and single-nucleus RNA sequencing: enrichment of adherent cell types in single-nucleus RNA sequencing
Single-cell ribonucleic acid (RNA) sequencing (scRNA-seq) is an effective technique for estimating the cellular composition and transcriptional...
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Dissociation protocols used for sarcoma tissues bias the transcriptome observed in single-cell and single-nucleus RNA sequencing
BackgroundSingle-cell RNA-seq has emerged as an innovative technology used to study complex tissues and characterize cell types, states, and lineages...
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Single-nucleus transcriptome sequencing reveals hepatic cell atlas in pigs
BackgroundAs the largest substantive organ of animals, the liver plays an essential role in the physiological processes of digestive metabolism and...
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scCDC: a computational method for gene-specific contamination detection and correction in single-cell and single-nucleus RNA-seq data
In droplet-based single-cell and single-nucleus RNA-seq assays, systematic contamination of ambient RNA molecules biases the quantification of gene...
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Single-nucleus RNA velocity reveals critical synaptic and cell-cycle dysregulations in neuropathologically confirmed Alzheimer’s disease
Typical differential single-nucleus gene expression (snRNA-seq) analyses in Alzheimer’s disease (AD) provide fixed snapshots of cellular alterations,...
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Single-nucleus analysis reveals microenvironment-specific neuron and glial cell enrichment in Alzheimer’s disease
BackgroundAlzheimer’s disease (AD) is a complicated neurodegenerative disease. Neuron-glial cell interactions are an important but not fully...
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Single-cell RNA-seq analysis reveals the Wnt/Ca2+ signaling pathway with inflammation, apoptosis in nucleus pulposus degeneration
BackgroundIncreasing studies have shown degeneration of nucleus pulposus cells (NPCs) as an critical part of the progression of intervertebral disc...
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Analysis of Single-Cell/Nucleus Transcriptome Data in Adipose Tissue
Adipose tissue is highly heterogeneous and plastic. Recent advances in single-cell/nucleus RNA sequencing technology have helped to study the...
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Plant Single-Cell/Nucleus RNA-seq Workflow
Single-cell transcriptomics technologies allow researchers to investigate how individual cells, in complex multicellular organisms, differentially...
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Single-nucleus multi-omics of human stem cell-derived islets identifies deficiencies in lineage specification
Insulin-producing β cells created from human pluripotent stem cells have potential as a therapy for insulin-dependent diabetes, but human pluripotent...
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Nucleus accumbens core single cell ensembles bidirectionally respond to experienced versus observed aversive events
Fear learning is a critical feature of survival skills among mammals. In rodents, fear learning manifests itself through direct experience of the...
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Single nucleus transcriptomic analysis of rat nucleus accumbens reveals cell type-specific patterns of gene expression associated with volitional morphine intake
Opioid exposure is known to cause transcriptomic changes in the nucleus accumbens (NAc). However, no studies to date have investigated cell...
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Human liver single nucleus and single cell RNA sequencing identify a hepatocellular carcinoma-associated cell-type affecting survival
BackgroundHepatocellular carcinoma (HCC) is a common primary liver cancer with poor overall survival. We hypothesized that there are HCC-associated...
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Major cell-types in multiomic single-nucleus datasets impact statistical modeling of links between regulatory sequences and target genes
Epigenomic profiling, including ATACseq, is one of the main tools used to define enhancers. Because enhancers are overwhelmingly cell-type specific,...
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Fine-grained cell-type specific association studies with human bulk brain data using a large single-nucleus RNA sequencing based reference panel
Brain disorders are leading causes of disability worldwide. Gene expression studies provide promising opportunities to better understand their...
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Single-nucleus RNA sequencing reveals cell type-specific transcriptome alterations of Down syndrome hippocampus using the Dp16 mouse model
BackgroundDown syndrome (DS), the most frequently occurring human chromosomal disorder, is caused by trisomy 21. The exact molecular effects of...
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Single-nucleus RNA sequencing of human pancreatic islets identifies novel gene sets and distinguishes β-cell subpopulations with dynamic transcriptome profiles
BackgroundSingle-cell RNA sequencing (scRNA-seq) provides valuable insights into human islet cell types and their corresponding stable gene...
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