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VIBRANT: spectral profiling for single-cell drug responses
High-content cell profiling has proven invaluable for single-cell phenoty** in response to chemical perturbations. However, methods with improved...
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Single-cell spatial metabolomics with cell-type specific protein profiling for tissue systems biology
Metabolic reprogramming in cancer and immune cells occurs to support their increasing energy needs in biological tissues. Here we propose Single Cell...
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Understanding Spondyloarthritis Pathogenesis: The Promise of Single-Cell Profiling
Purpose of ReviewSingle-cell profiling, either in suspension or within the tissue context, is a rapidly evolving field. The purpose of this review is...
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Scalable single-cell profiling of chromatin modifications with sciCUT&Tag
Cleavage under targets and tagmentation (CUT&Tag) is an antibody-directed in situ chromatin profiling strategy that is rapidly replacing immune...
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Advances in single-cell omics and multiomics for high-resolution molecular profiling
Single-cell omics technologies have revolutionized molecular profiling by providing high-resolution insights into cellular heterogeneity and...
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Identification of a clinically efficacious CAR T cell subset in diffuse large B cell lymphoma by dynamic multidimensional single-cell profiling
Chimeric antigen receptor (CAR) T cells used for the treatment of B cell malignancies can identify T cell subsets with superior clinical activity....
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Profiling joint tissues at single-cell resolution: advances and insights
Advances in the profiling of human joint tissues at single-cell resolution have provided unique insights into the organization and function of these...
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Single-cell T-cell receptor repertoire profiling in dogs
Spontaneous cancers in companion dogs are robust models of human disease. Tracking tumor-specific immune responses in these models requires reagents...
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Large-scale neurophysiology and single-cell profiling in human neuroscience
Advances in large-scale single-unit human neurophysiology, single-cell RNA sequencing, spatial transcriptomics and long-term ex vivo tissue culture...
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Morphological profiling by high-throughput single-cell biophysical fractometry
Complex and irregular cell architecture is known to statistically exhibit fractal geometry, i.e., a pattern resembles a smaller part of itself....
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Principles, challenges, and advances in ribosome profiling: from bulk to low-input and single-cell analysis
Ribosome profiling has revolutionized our understanding of gene expression regulation by providing a snapshot of global translation in vivo. This...
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Profiling Single-Cell Genome and Transcriptome by scONE-Seq
Single-cell multi-omics technologies can provide a unique perspective on tumor cellular heterogeneity. We have developed a versatile method for...
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High-capacity sample multiplexing for single cell chromatin accessibility profiling
Single-cell chromatin accessibility has emerged as a powerful means of understanding the epigenetic landscape of diverse tissues and cell types, but...
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Immunophenoty** with (phospho)protein profiling and fluorescent cell barcoding for single-cell signaling analysis and biomarker discovery
The microenvironment of hematologic cancers contributes to tumor cell survival and proliferation, as well as treatment resistance. Understanding...
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Droplet-based bisulfite sequencing for high-throughput profiling of single-cell DNA methylomes
The genome-wide DNA methylation profile, or DNA methylome, is a critical component of the overall epigenomic landscape that modulates gene activities...
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Emerging applications of single-cell profiling in precision medicine of atherosclerosis
Atherosclerosis is a chronic, progressive, inflammatory disease that occurs in the arterial wall. Despite recent advancements in treatment aimed at...
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Combinatorial single-cell profiling of major chromatin types with MAbID
Gene expression programs result from the collective activity of numerous regulatory factors. Studying their cooperative mode of action is imperative...
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Joint single-cell profiling resolves 5mC and 5hmC and reveals their distinct gene regulatory effects
Oxidative modification of 5-methylcytosine (5mC) by ten-eleven translocation (TET) DNA dioxygenases generates 5-hydroxymethylcytosine (5hmC), the...
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Single-cell transcriptional profiling of clear cell renal cell carcinoma reveals a tumor-associated endothelial tip cell phenotype
Clear cell renal cell carcinoma (ccRCC) is the most prevalent form of renal cancer, accounting for over 75% of cases. The asymptomatic nature of the...
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Nanobody-tethered transposition enables multifactorial chromatin profiling at single-cell resolution
Chromatin states are functionally defined by a complex combination of histone modifications, transcription factor binding, DNA accessibility and...
