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Septic Shock
Septic shock is a life-threatening condition resulting in the dysregulation of the host defense mechanisms in response to a pathogen. As its... -
Case report: septic shock after endometrial polypectomy with tissue removal system
As an emerging surgical technology, tissue removal systems have been widely used in the treatment of endometrial polyps due to its characteristics of...
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Sepsis and Septic Shock
This chapter outlines the essentials and most current concepts and understanding of the relevant epidemiology, definitions, pathogenesis, diagnosis... -
Sepsis and Septic Shock
Sepsis and septic shock are among the leading causes of admission to ICU. This chapter focuses on clinically relevant pathophysiology and its... -
Impaired angiotensin II signaling in septic shock
Recent years have seen a resurgence of interest for the renin–angiotensin–aldosterone system in critically ill patients. Emerging data suggest that...
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Septic Coagulopathy: Pathophysiology, Diagnosis, and Therapeutic Strategies
Purpose of ReviewSeptic coagulopathy is a complex disorder linked with multiple organ dysfunction and increased mortality, and definitive treatments...
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Precision Medicine in Septic Shock
All patients with septic shock should be given the fundamental pillars of sepsis management (source control, antibiotic stewardship, initial... -
Septic Tanks as Small Municipal Sewage Treatment Plants
The function of a septic tank is primarily to retain wastewater and purify it in an anaerobic process. Septic tanks are differentiated by flow rate... -
A model of porcine polymicrobial septic shock
BackgroundSepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Mortality of patients with sepsis is...
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The role of endotoxin in septic shock
Septic shock can be caused by a variety of mechanisms including direct effects of bacterial toxins such as endotoxin. Annually, approximately 5–7...
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Septic Shock, Tubular Necrosis, and Central Diabetes Insipidus: A Challenging Syndrome
BackgroundThe association between septic shock, acute tubular necrosis, and central diabetes insipidus is infrequent: our recent clinical observation...
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In Silico Modeling of Antibiotics Treatment Combined with Corticosteroids for Septic Arthritis
Septic arthritis is a bacterial infection in the joint fluid and joint tissues. Although it is rare, septic arthritis is a serious condition—it can... -
Whole blood transcriptomics identifies subclasses of pediatric septic shock
BackgroundSepsis is a highly heterogeneous syndrome, which has hindered the development of effective therapies. This has prompted investigators to...
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Septic Arthritis
Pediatric septic arthritis is a surgical emergency that requires multidisciplinary diagnosis and management. A high clinical suspicion with... -
Melatonin alleviates septic ARDS by inhibiting NCOA4-mediated ferritinophagy in alveolar macrophages
Ferroptosis is a novel form of programmed cell death which can exacerbate lung injury in septic acute respiratory distress syndrome (ARDS). Alveolar...
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Blockade of sympathetic ganglia improves vascular dysfunction in septic shock
Sepsis/septic shock activates the sympathetic nervous system (SNS) to deal with the infection stress. However, an imbalanced or maladaptive response...
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Assessment of hemodynamic dysfunction in septic newborns by functional echocardiography: a systematic review
BackgroundNeonatal sepsis remains a leading cause of mortality in neonatal units. Neonatologist-performed echocardiography (NPE) offers the potential...
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Carbapenem is not always the best choice in the treatment of septic shock
BackgroundSeptic shock is a global public health burden. In addition to the improvement of the level of individual care, the improvement of the...
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Inhibitory Activities of GDX-365 on HMGB1-mediated Septic Responses
GDX-365, is the main fraction of black ginseng comprising protopanaxatriol-type rare ginsenosides (ginsenosides Rg3, Rk1, and Rg5). High mobility...
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Diastolic/systolic blood pressure ratio for predicting febrile children with sepsis and progress to septic shock in the emergency department
ObjectiveGiven the scarcity of studies analyzing the clinical predictors of pediatric septic cases that would progress to septic shock, this study...