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Loosely synchronized activation of anterior cingulate cortical neurons for scratching response during histamine-induced itch
Itch is a distinctive sensation that causes a specific affection and scratching reaction. The anterior cingulate cortex (ACC) has been linked to itch...
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Yawning and scratching contagion in wild spider monkeys (Ateles geoffroyi)
Behavioural contagion is a widespread phenomenon in animal species, which is thought to promote coordination and group cohesion. Among non-human...
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Imiquimod-induced pruritus in female wild-type and knockin Wistar rats: underscoring behavioral scratching in a rat model for antipruritic treatments
ObjectivesAnimal models of skin disease are used to evaluate therapeutics to alleviate disease. One common clinical dermatological complaint is...
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Exploring neuronal mechanisms involved in the scratching behavior of a mouse model of allergic contact dermatitis by transcriptomics
BackgroundAllergic contact dermatitis (ACD) is a common skin condition characterized by contact hypersensitivity to allergens, accompanied with skin...
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Region-specific activation in the accumbens nucleus by itch with modified scratch efficacy in mice – a model-free multivariate analysis
Itch is a protective/defensive function with divalent motivational drives. Itch itself elicits an unpleasant experience, which triggers the urge to...
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Neural pathways that compel us to scratch an itch
Itch is a unique sensory experience that is responded to by scratching. How pruritogens, which are mechanical and chemical stimuli with the potential...
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The lateral habenula nucleus regulates pruritic sensation and emotion
Itch is a complex aversive sensory and emotional experience. As a most upsetting symptom in many dermatological and systemic diseases, it lacks...
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The Sapap3−/− mouse reconsidered as a comorbid model expressing a spectrum of pathological repetitive behaviours
Symptom comorbidity is present amongst neuropsychiatric disorders with repetitive behaviours, complicating clinical diagnosis and impeding...
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PIEZO1 transduces mechanical itch in mice
Itch triggers scratching, a behavioural defence mechanism that aids in the removal of harmful irritants and parasites
1 . Chemical itch is triggered by...
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Hypothalamic orexinergic neurons modulate pain and itch in an opposite way: pain relief and itch exacerbation
Pain and itch are recognized as antagonistic sensations; pain suppresses itch and inhibition of pain generates itch. There is still a lack of...
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The effects of visitors and social isolation from a peer on the behavior of a mixed-species pair of captive gibbons
Human visitors affect the behavior of captive animals, which is the so-called visitor effect. The number and behavior of visitors may influence...
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Anti-pruritic effect of L-carnitine against chloroquine-induced pruritus mediated via nitric oxide pathway
BackgroundPruritus, or itching, is a distressing symptom associated with various dermatological and systemic diseases. L-carnitine (βeta...
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Sophorolipid inhibits histamine-induced itch by decreasing PLC/IP3R signaling pathway activation and modulating TRPV1 activity
Biosurfactants are attracting much interest due to their potential application as therapeutic agents in the medical and cosmetic field. Previous...
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Role of gut-derived bacterial lipopolysaccharide and peripheral TLR4 in immobilization stress-induced itch aggravation in a mouse model of atopic dermatitis
Psychological stress and intestinal leakage are key factors in atopic dermatitis (AD) recurrence and exacerbation. Here, we demonstrate the...
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Acupuncture attenuates comorbid anxiety- and depressive-like behaviors of atopic dermatitis through modulating neuroadaptation in the brain reward circuit in mice
Atopic dermatitis (AD) is highly comorbid with negative emotions such as anxiety and depression. Although acupuncture has demonstrated efficacy in...
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Mitochondrial Reactive Oxygen Species Elicit Acute and Chronic Itch via Transient Receptor Potential Canonical 3 Activation in Mice
Mitochondrial reactive oxygen species (mROS) that are overproduced by mitochondrial dysfunction are linked to pathological conditions including...
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Neuronal pentraxin 2 is required for facilitating excitatory synaptic inputs onto spinal neurons involved in pruriceptive transmission in a model of chronic itch
An excitatory neuron subset in the spinal dorsal horn (SDH) that expresses gastrin-releasing peptide receptors (GRPR) is critical for pruriceptive...
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The mouse model of fragile X syndrome exhibits deficits in contagious itch behavior
Individuals with autism spectrum disorders (ASDs) imitate observed behavior less than age-matched and typically develo** peers, resulting in...
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Caffeic acid phenethyl ester inhibits pseudo-allergic reactions via inhibition of MRGPRX2/MrgprB2-dependent mast cell degranulation
Mast cells play essential role in allergic reactions through the process called mast cell degranulation. Recent studies have found that a basic...
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Precursors and aftermath of severe targeted aggression in captive cotton-top tamarins
We observed a zoo-housed group of cotton-top tamarins ( Saguinus oedipus ) before and after a bout of severe targeted aggression directed towards two...
