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The HHEX-ABI2/SLC17A9 axis induces cancer stem cell-like properties and tumorigenesis in HCC
Accumulating evidence indicated that HHEX participated in the initiation and development of several cancers, but the potential roles and mechanisms...
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Excitatory purinergic and cholinergic expression changed in a partial bladder outlet obstruction-induced overactive bladder rat model
Overactive bladder (OAB) is a common, long-term symptom complex with a high prevalence in women worldwide. OAB has caused a social burden, and...
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Epigenetic differences at the HTR2A locus in progressive multiple sclerosis patients
The pathology of progressive multiple sclerosis (MS) is poorly understood. We have previously assessed DNA methylation in the CD4 + T cells of...
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Nitrergic and Purinergic Nerves in the Small Intestinal Myenteric Plexus and Circular Muscle of Mice and Guinea Pigs
ATP is an excitatory and inhibitory neurotransmitter, while nitric oxide (NO) is an inhibitory neurotransmitter in the enteric nervous system (ENS)....
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Amino Acid Transporters Proteins Involved in the Glutamate-Glutamine Cycle and Their Alterations in Murine Models of Alzheimer’s Disease
The brain’s ability to integrate external stimuli and generate responses is highly complex. While these mechanisms are not completely understood,...
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Harnessing function of EMT in cancer drug resistance: a metastasis regulator determines chemotherapy response
Epithelial-mesenchymal transition (EMT) is a complicated molecular process that governs cellular shape and function changes throughout tissue...
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Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude
BackgroundSeasonal variations in environmental exposures at birth or during gestation are associated with numerous adult traits and health outcomes...
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Etidronate attenuates tactile allodynia by spinal ATP release inhibition in mice with partial sciatic nerve ligation
Etidronate is widely used as a therapeutic agent for osteoporosis. We have recently shown that intrathecal administration of etidronate into mice...
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CRISPR/Cas9 mediated Y-chromosome elimination affects human cells transcriptome
BackgroundSexual dimorphism represents a key concept in the comprehension of molecular processes guiding several sex-specific physiological and...
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María Teresa Miras Portugal: a pioneer for vesicular nucleotide storage
Chromaffin granules are secretory granules present in adrenal medulla chromaffin cells. They contain high contents of catecholamines and nucleotides...
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The synergism of cytosolic acidosis and reduced NAD+/NADH ratio is responsible for lactic acidosis-induced vascular smooth muscle cell impairment in sepsis
BackgroundDuring sepsis, serve vascular dysfunctions lead to life-threatening multiple organ failure, due to vascular smooth muscle cells (VSMC)...
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Development of Purinergic Receptor Agonists and Antagonists
Adenosine, P2Y, and P2X receptors have been the focus of purinergic ligand development in the pharmaceutical sector and academic medicinal chemistry...
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Transcriptome profiling analysis of uterus during chicken laying periods
The avian eggshell is formed in the uterus. Changes in uterine function may have a significant effect on eggshell quality. To identify the vital...
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Co-expression of cancer-testis antigens of MAGE-A6 and MAGE-A11 is associated with tumor aggressiveness in patients with bladder cancer
Melanoma antigen gene (MAGE)-A6 and MAGE-A11 are two of the most cancer-testis antigens overexpressed in various types of cancers. However, the...
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Quinacrine is not a vital fluorescent probe for vesicular ATP storage
Quinacrine, a fluorescent amphipathic amine, has been used as a vital fluorescent probe to visualize vesicular storage of ATP in the field of...
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Fluorescent Labeling and Quantification of Vesicular ATP Release Using Live Cell Imaging
Adenosine triphosphate (ATP) is actively transported into vesicles for purinergic neurotransmission by the vesicular nucleotide transporter, VNUT,...
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Mechanisms of ATP release in pain: role of pannexin and connexin channels
Pain is a physiological response to bodily damage and serves as a warning of potential threat. Pain can also transform from an acute response to...
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Genome-Wide Association Study Reveals SNPs and Candidate Genes Related to Growth and Body Shape in Bighead Carp (Hypophthalmichthys nobilis)
Growth is an economically important trait in bighead carp and other aquaculture species that affects production efficiency. Interestingly, the head...
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Identification and functional analysis of LncRNA-XIST ceRNA network in prostate cancer
BackgroundLong non-coding RNAs (lncRNAs) play a functional role in the progression of prostate cancer (PCa). However, the molecular mechanism,...
