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Prediction of postoperative respiratory depression and respiratory complications in patients on preoperative methadone
PurposeWe developed prediction models for postoperative respiratory depression and respiratory complications for 958 patients who were on methadone...
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Whole body physiology model to simulate respiratory depression of fentanyl and associated naloxone reversal
BackgroundOpioid use in the United States and abroad is an endemic part of society with yearly increases in overdose rates and deaths. In response,...
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Latent neural population dynamics underlying breathing, opioid-induced respiratory depression and gas**
Breathing is vital and must be concurrently robust and flexible. This rhythmic behavior is generated and maintained within a rostrocaudally aligned...
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Mechanisms of opioid-induced respiratory depression
Opioid-induced respiratory depression (OIRD), the primary cause of opioid-induced death, is the neural depression of respiratory drive which,...
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Respiratory depression following cesarean section with single-shot spinal with 100 μg morphine
PurposeLittle evidence is available regarding bradypnea measured using continuous monitoring following cesarean section. We aimed to evaluate the...
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Neonatal opioid toxicity: opioid withdrawal (abstinence) syndrome with emphasis on pharmacogenomics and respiratory depression
The increasing use of opioids in pregnant women has led to an alarming rise in the number of cases of neonates with drug-induced withdrawal symptoms...
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The use of gabapentinoids and opioids and risk of develo** opioid-induced respiratory depression among older breast cancer survivors with neuropathic pain
PurposeTo estimate the combined effect of gabapentinoid and opioid therapy compared to opioid monotherapy on the risk of develo** opioid-induced...
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Incidence of postoperative opioid-induced respiratory depression episodes in patients on room air or supplemental oxygen: a post-hoc analysis of the PRODIGY trial
BackgroundSupplemental oxygen (SO) potentiates opioid-induced respiratory depression (OIRD) in experiments on healthy volunteers. Our objective was...
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Mitochondria-wide association study observed significant interactions of mitochondrial respiratory and the inflammatory in the development of anxiety and depression
The aim of this study was to investigate the possible interaction of mitochondrial dysfunction and inflammatory cytokines in the risk of anxiety and...
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Postoperative respiratory depression in patients on sublingual buprenorphine: a retrospective cohort study for comparison between postoperative continuation and discontinuation of buprenorphine
BackgroundWe tested the hypothesis that patients who continued buprenorphine postoperatively experience postoperative respiratory depression less...
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Depression and Noninvasive Ventilation
The co-occurrence of depression and respiratory conditions is frequent. The resource to noninvasive ventilation is increasing and is now a first-line...
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Respiratory Acidosis
In this chapter, the mechanisms of carbon dioxide balance, pathophysiology, causes, diagnosis, clinical manifestations, and management of acute and...
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Patterns of Psychology Responses in Acute and Chronic Respiratory Failure
Patterns of psychological response to diseases causing respiratory failure could include a broad range of conditions including behavioral...
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Measurements and Scores: Hospital Anxiety and Depression Scale (HADS)
Psychological disorders such as anxiety and depression are common problems in population, with particularly high morbidity in patients with chronic...
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CYX-5, a G-protein biassed MOP receptor agonist, DOP receptor antagonist and KOP receptor agonist, evokes constipation but not respiratory depression relative to morphine in rats
BackgroundStrong opioid analgesics such as morphine alleviate moderate to severe acute nociceptive pain (e.g. post-surgical or post-trauma pain) as...
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Respiratory Failure and Respiratory Support
The main reasons for instituting mechanical ventilation are to decrease the work of breathing, support gas exchange, and buy time for other...
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Respiratory Emergencies
The physiologic changes that occur at altitude can put travelers at risk for respiratory decompensation in flight. While plenty of respiratory...
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Sex/Gender Differences in Respiratory Diseases
Sex/gender-specific differences in the respiratory system begin with intrauterine lung development and continue throughout childhood and adulthood....
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Dementia, Delirium, and Depression
Changes in mental status can affect many residents during their stay in a post-acute or long-term care (PA/LTC) facility. Changes in cognition can...
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Blood-based mitochondrial respiratory chain function in major depression
Mitochondrial dysfunction has been implicated in major depressive disorder (MDD). A measure of mitochondrial respiratory chain (RC) enzymatic...
