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MBD1 protects replication fork stability by recruiting PARP1 and controlling transcription-replication conflicts
The replication-stress response is essential to ensure the faithful transmission of genetic information to daughter cells. Although several...
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Replication fork uncoupling causes nascent strand degradation and fork reversal
Genotoxins cause nascent strand degradation (NSD) and fork reversal during DNA replication. NSD and fork reversal are crucial for genome stability...
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H2AX promotes replication fork degradation and chemosensitivity in BRCA-deficient tumours
Histone H2AX plays a key role in DNA damage signalling in the surrounding regions of DNA double-strand breaks (DSBs). In response to DNA damage, H2AX...
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Gene duplication and deletion caused by over-replication at a fork barrier
Replication fork stalling can provoke fork reversal to form a four-way DNA junction. This remodelling of the replication fork can facilitate repair,...
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TFIP11 promotes replication fork reversal to preserve genome stability
Replication fork reversal, a critical protective mechanism against replication stress in higher eukaryotic cells, is orchestrated via a series of...
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Nuclear actin polymerization rapidly mediates replication fork remodeling upon stress by limiting PrimPol activity
Cells rapidly respond to replication stress actively slowing fork progression and inducing fork reversal. How replication fork plasticity is achieved...
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Genome-wide identification of replication fork stalling/pausing sites and the interplay between RNA Pol II transcription and DNA replication progression
BackgroundDNA replication progression can be affected by the presence of physical barriers like the RNA polymerases, leading to replication stress...
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Replication fork binding triggers structural changes in the PriA helicase that govern DNA replication restart in E. coli
Bacterial replisomes often dissociate from replication forks before chromosomal replication is complete. To avoid the lethal consequences of such...
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Regulation of Rad52-dependent replication fork recovery through serine ADP-ribosylation of PolD3
Although Poly(ADP-ribose)-polymerases (PARPs) are key regulators of genome stability, how site-specific ADP-ribosylation regulates DNA repair is...
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UFL1 triggers replication fork degradation by MRE11 in BRCA1/2-deficient cells
The stabilization of stalled forks has emerged as a crucial mechanism driving resistance to poly(ADP-ribose) polymerase (PARP) inhibitors in...
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Dynamic de novo heterochromatin assembly and disassembly at replication forks ensures fork stability
Chromatin is dynamically reorganized when DNA replication forks are challenged. However, the process of epigenetic reorganization and its implication...
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Synergism between CMG helicase and leading strand DNA polymerase at replication fork
The replisome that replicates the eukaryotic genome consists of at least three engines: the Cdc45-MCM-GINS (CMG) helicase that separates duplex DNA...
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Interferon restores replication fork stability and cell viability in BRCA-defective cells via ISG15
DNA replication and repair defects or genotoxic treatments trigger interferon (IFN)-mediated inflammatory responses. However, whether and how IFN...
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Genome-wide measurement of DNA replication fork directionality and quantification of DNA replication initiation and termination with Okazaki fragment sequencing
Studying the dynamics of genome replication in mammalian cells has been historically challenging. To reveal the location of replication initiation...
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Monitoring and quantifying replication fork dynamics with high-throughput methods
Before each cell division, eukaryotic cells must replicate their chromosomes to ensure the accurate transmission of genetic information. Chromosome...
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Nuclear myosin VI maintains replication fork stability
The actin cytoskeleton is of fundamental importance for cellular structure and plasticity. However, abundance and function of filamentous actin in...
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The COMPASS subunit Spp1 protects nascent DNA at the Tus/Ter replication fork barrier by limiting DNA availability to nucleases
Homologous recombination factors play a crucial role in protecting nascent DNA during DNA replication, but the role of chromatin in this process is...
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Parental histone transfer caught at the replication fork
In eukaryotes, DNA compacts into chromatin through nucleosomes
1 ,2 . Replication of the eukaryotic genome must be coupled to the transmission of the...
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Compartmentalization of the replication fork by single-stranded DNA-binding protein regulates translesion synthesis
Processivity clamps tether DNA polymerases to DNA, allowing their access to the primer–template junction. In addition to DNA replication, DNA...
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The chromatin-associated lncREST ensures effective replication stress response by promoting the assembly of fork signaling factors
Besides the well-characterized protein network involved in the replication stress response, several regulatory RNAs have been shown to play a role in...
