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Randomized Controlled Trials in Orthodontics
There has been an exponential increase in the number of randomized studies within orthodontics over the past three decades. However, issues remain in...
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Randomized Controlled Trials in Endodontics
The randomized clinical trial (RCT) is the most rigorous way of determining cause-and-effect between treatment and outcome, also providing data...
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Randomized Controlled Trials in Geriatric Dentistry
The population of older adults in all parts of the world is rising, and they also constitute a segment of patients with high risk for oral diseases...
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Appraisal of Randomized Sham-Controlled Trial Data on Renal Denervation for the Management of Hypertension
The following text provides a brief summary of pivotal non-randomized and randomized non-sham controlled trials followed by a more detailed...
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A randomized controlled trial evaluating the effects of motivational interviewing in new hearing aid users (MI-HAT): study protocol for a randomized controlled trial
BackgroundHearing loss is the third leading global cause of disability and is associated with poorer quality of life. Hearing aids are often...
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Randomized controlled trial of intravenous immunoglobulin for autoimmune postural orthostatic tachycardia syndrome (iSTAND)
ObjectiveThis study assesses response to intravenous immunoglobulin (IVIG) in presumed autoimmune postural orthostatic tachycardia syndrome (POTS).
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Randomized Controlled Trials in Oral and Maxillofacial Surgery
This chapter reviews the published literature for randomized controlled trials in oral and maxillofacial surgery. Two-hundred-thirty-two studies were...
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Escitalopram for Older Adults with Generalized Anxiety Disorder: A Randomized Controlled Trial
In this study, the investigators conducted a 12-week randomized placebo-controlled trial that evaluated the use of escitalopram for the treatment of...
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The LIVER CARE trial — screening for liver disease in individuals attending treatment for alcohol use disorder: a randomized controlled feasibility trial
BackgroundAlcohol-related liver disease is a preventable disease with high mortality. If individuals with alcohol-related liver disease were to be...
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LapEmerge trial: study protocol for a laparoscopic approach for emergency colon resection—a multicenter, open label, randomized controlled trial
BackgroundDue to faster recovery and lower morbidity rates, laparoscopy has become the gold standard in elective colorectal surgery for both the...
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The Skin Antiseptic agents at Vaginal dElivery (SAVE) trial: study protocol for a randomized controlled trial
BackgroundCleansing of the vulva and perineum is recommended during preparation for vaginal delivery, and special attention is paid to cleansing...
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Drainless robot-assisted minimally invasive oesophagectomy—randomized controlled trial (RESPECT)
BackgroundThe purpose of this randomized trial is to evaluate the early removal of postoperative drains after robot-assisted minimally invasive...
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Randomized controlled trial of intermittent hypoxia in Parkinson’s disease: study rationale and protocol
BackgroundParkinson’s disease (PD) is a neurodegenerative disease for which no disease-modifying therapies exist. Preclinical and clinical evidence...
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Doxapram versus placebo in preterm newborns: a study protocol for an international double blinded multicentre randomized controlled trial (DOXA-trial)
BackgroundApnoea of prematurity (AOP) is one of the most common diagnoses among preterm infants. AOP often leads to hypoxemia and bradycardia which...
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Nurse-Guided Maternal Interventional Package for Neonatal Stress–A Randomized Controlled Trial
ObjectiveTo assess the role of nurse-guided maternal interventional package for reducing stress behaviour among preterm neonates admitted in neonatal...
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Effect of chest shielding during phototherapy for hyperbilirubinemia on symptomatic patent ductus arteriosus – a double-blind randomized placebo-controlled trial
BackgroundMeta-analysis of randomized trials suggests that phototherapy is associated with patent ductus arteriosus (PDA). We hypothesized that chest...
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High-dose cephalexin for cellulitis: a pilot randomized controlled trial
BackgroundUp to 3% of all Emergency Department (ED) visits are due to skin and soft tissue infections such as non-purulent cellulitis. The current...
