Search
Search Results
-
Synthesis and evaluation of pyridine-3-carboxamide analogs as effective agents against bacterial wilt in tomatoes
This study focused on develo** novel pyridine-3-carboxamide analogs to treat bacterial wilt in tomatoes caused by Ralstonia solanacearum . The...
-
Solid State Synthesis, Spectroscopic, X-ray and Antibacterial Studies of Zn(II) and Fe(III) Complexes of Pyridine-3-Carboxamide and 2-Hydroxybenzoic Acid
Mixed-ligand metal complexes are being prepared under solvent-free conditions and this has formed a vital ongoing research focus. One of the purposes...
-
New Syntheses of Cycloalka[c]pyridine-3-carboxamide and -carbonitrile Derivatives
AbstractNicotinamide and nicotinonitrile derivatives containing a C 5 –C 7 -cycloalkane ring fused to the C 4 –C 5 bond were synthesized via Knoevenagel...
-
Homology modeling and molecular docking simulation of some novel imidazo[1,2-a]pyridine-3-carboxamide (IPA) series as inhibitors of Mycobacterium tuberculosis
BackgroundTuberculosis (TB) remains a serious global health challenge that is caused by Mycobacterium tuberculosis and has killed numerous people....
-
Synthesis of Benzothiazole/Benzimidazole-Conjugated Imidazoles as Anticancer Agents and Their Molecular Modeling
AbstractAn efficient and high-yielding method was developed for the synthesis of N -(benzo[ d ]thiazol-2-yl)-6-methoxy-5-(4-methyl-1 H -imidazol-1-yl)pyri...
-
Design, Synthesis, and Insecticidal Activity of Novel Diacylhydrazine Derivatives Containing an Isoxazole Carboxamide or a Pyridine Carboxamide Moiety
AbstractIn this study, two series of novel diacylhydrazine derivatives containing an isoxazole carboxamide or a pyridine carboxamide moiety have been...
-
The biological effects and thermal degradation of NPB-22, a synthetic cannabinoid
PurposeNPB-22 (quinolin-8-yl 1-pentyl-1 H -indazole-3-carboxylate), Adamantyl-THPINACA ( N -(1-adamantantyl)-1-[(tetrahydro-2 H -pyran-4-yl)methyl]-1 H -inda...
-
Carboxamide: based chemosensor grafted on SBA-15 nanostructure for selective detection of Hg2+ ion in an aqueous solution
A new adeninecarboxamide ligand, N-(9 H-purin-6-yl) pyridine-2-carboxamide (H 2 pzac) has been synthesized by a green chemistry method using...
-
DFT and TDDFT exploration on the role of pyridyl ligands with copper toward bonding aspects and light harvesting
ContextSchiff base-containing metal complexes have been the subject of extensive research. In this work, a coordination polymer-derived complex...
-
Synthesis of New Polycyclic Compounds Containing Thieno[2′,3′:5,6]pyrimido[2,1-a]isoindole Fragment
AbstractThe reaction of partially saturated derivatives of 3-aminothieno[2,3- b ]pyridine-2-carboxamide with phthalic anhydride in acetic acid or DMF...
-
Synthesis, characterization, crystal structure, hirshfeld surface analysis and DFT calculations of N-(pyridin-2-ylmethyl)furan-2-carboxamide and its molecular docking
The crystal structure of N -(pyridin-2-ylmethyl)furan-2-carboxamide was elucidated by single crystal X-ray diffraction and characterized by NMR,...
-
Synthesis and Anticancer Activity of New Thiophene, Thiazolyl-Thiophene, and Thienopyridine Derivatives
AbstractNew 4-acetyl-5-anilino- N -arylthiophene-2-carboxamide derivatives have been synthesized by reaction of 2-acetyl-3-oxo- N -phenylbutanethioamide...
-
3-Aminofuro[2,3-b]pyridines: Reaction with N-Chlorosuccinimide and Sodium Hypochlorite
AbstractThe reaction of aminoamides of the furo[2,3- b ]pyridine series with an aqueous solution of sodium hypochlorite and N -chlorosuccinimide was...
-
Design, Synthesis, and Anticancer Activity of Novel Methoxycyclohexyl Nicotinamides
AbstractOver the past decade, the molecular targeted therapies have been found beneficial. These therapies utilize small chemical molecules which...
-
Substituted furan-carboxamide and Schiff base derivatives as potential hypolipidemic compounds: evaluation in Triton WR-1339 hyperlipidemic rat model
Substituted furan carboxamide and Schiff base derivatives were evaluated for their hypolipidemic activity. Fourteen derivatives were synthesised:...
-
Synthesis and Antiproliferative Activity of 2-Oxo-4-Cyano-1,2-Dihydropyridine-3-Carboxamides
2-Oxo-4-cyano-1,2-dihydropyridine-3-carboxamides were synthesized. Their antiproliferative activity was studied. They were shown to inhibit slightly...
-
Pyrazole-sulfonamide scaffold featuring dual-tail strategy as apoptosis inducers in colon cancer
Dual-tail strategy has been successfully utilized in the development of novel carbonic anhydrase IX (CA IX) inhibitors. Herein we adopted this...
-
Novel biologically active pyridine derivatives: Synthesis, structure characterization, in vitro antimicrobial evaluation and structure-activity relationship
The rate of microbial resistance has continued to rise significantly as the availability of new antibiotics has declined. A new series of pyridine...
-
Design, synthesis, and evaluation of thiazolecarboxamide derivatives as stimulator of interferon gene inhibitors
Stimulator of interferon gene (STING) plays critical roles in the cytoplasmic DNA-sensing pathway and in the induction of inflammatory response....
-
Synthesis, molecular docking and molecular dynamics simulations, drug-likeness studies, ADMET prediction and biological evaluation of novel pyrazole-carboxamides bearing sulfonamide moiety as potent carbonic anhydrase inhibitors
Pyrazoles are unique bioactive molecules with a versatile biological profile and they have gained an important place on pharmaceutical chemistry....
