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1. The fibro-adipogenic progenitor APOD+DCN+LUM+ cell population in aggressive carcinomas

   We identified a progenitor cell population highly enriched in samples from invasive and chemo-resistant carcinomas, characterized by a well-defined...

   Lingyi Cai, Mikhail G. Kolonin, Dimitris Anastassiou in Cancer and Metastasis Reviews

   Article Open access 11 March 2024
   

2. Identification of a rare Gli1⁺ progenitor cell population contributing to liver regeneration during chronic injury

   In adults, hepatocytes are mainly replenished from the existing progenitor pools of hepatocytes and cholangiocytes during chronic liver injury....

   Jiayin Peng, Fei Li, ... Yun Zhao in Cell Discovery

   Article Open access 01 November 2022
   

3. A statistical method for quantifying progenitor cells reveals incipient cell fate commitments

   Quantifying the number of progenitor cells that found an organ, tissue or cell population is of fundamental importance for understanding the...

   Shanjun Deng, Han Gong, ... **onglei He in Nature Methods

   Article 20 February 2024
   

4. Single-cell transcriptomics uncovers EGFR signaling-mediated gastric progenitor cell differentiation in stomach homeostasis

   Defects in gastric progenitor cell differentiation are associated with various gastric disorders, including atrophic gastritis, intestinal...

   Hitomi Takada, Yohei Sasagawa, ... Akira Kurisaki in Nature Communications

   Article Open access 29 June 2023
   

5. Neural Stem/Progenitor Cell (NSPC) Extraction and Culture

   Neural stem–progenitor cells (NSPCs) are multipotent, self-renewing cells that generate radial glial cells (RGC). RGCs then give rise to neurons and...

   Jemma Gasperoni, Sebastian Dworkin in Neurobiology

   Protocol 2024
   

6. Modeled microgravity unravels the roles of mechanical forces in renal progenitor cell physiology

   Background

   The glomerulus is a highly complex system, composed of different interdependent cell types that are subjected to various mechanical...

   Maria Elena Melica, Francesca Cialdai, ... Laura Lasagni in Stem Cell Research & Therapy

   Article Open access 17 January 2024
   

7. Cardiac progenitor cell therapy: mechanisms of action

   Heart failure (HF) is an end-stage of many cardiac diseases and one of the main causes of death worldwide. The current management of this disease...

   Rut Bryl, Magdalena Kulus, ... Bartosz Kempisty in Cell & Bioscience

   Article Open access 05 March 2024
   

8. Muscle Progenitor Cell Fusion in the Maintenance of Skeletal Muscle

   Skeletal muscle possesses a resident, multipotent stem cell population that is essential for its repair and maintenance throughout life. Here I...

   Jarred M. Whitlock in Syncytia: Origin, Structure, and Functions

   Chapter 2024
   

9. Wnt signaling preserves progenitor cell multipotency during adipose tissue development

   Mesenchymal stem/progenitor cells are essential for tissue development and repair throughout life, but how they are maintained under chronic...

   Zinger Yang Loureiro, Shannon Joyce, ... Silvia Corvera in Nature Metabolism

   Article Open access 19 June 2023
   

10. TCF1–LEF1 co-expression identifies a multipotent progenitor cell (T_H2-MPP) across human allergic diseases

    Repetitive exposure to antigen in chronic infection and cancer drives T cell exhaustion, limiting adaptive immunity. In contrast, aberrant, sustained...

    Radomir Kratchmarov, Sarah Djeddi, ... Patrick J. Brennan in Nature Immunology

    Article 08 April 2024
    

11. A single-cell transcriptional atlas reveals resident progenitor cell niche functions in TMJ disc development and injury

    The biological characteristics of the temporomandibular joint disc involve complex cellular network in cell identity and extracellular matrix...

    Ruiye Bi, Qing Yin, ... Songsong Zhu in Nature Communications

    Article Open access 14 February 2023
    

12. Emetine induces oxidative stress, cell differentiation and NF-κB inhibition, suppressing AML stem/progenitor cells

    Acute myeloid leukemia (AML) is a fatal malignancy of the blood and bone marrow. Leukemic stem cells (LSCs) are a rare subset of leukemic cells that...

    Suellen L. R. Silva, Ingrid R. S. B. Dias, ... Daniel P. Bezerra in Cell Death Discovery

    Article Open access 29 April 2024
    

13. Extracellular miR-6723-5p could serve as a biomarker of limbal epithelial stem/progenitor cell population

    Background

    Dysfunction or loss of limbal stem cells can result in limbal stem cell deficiency (LSCD), a disease that cause corneal opacity, pain, and...

    M. Ruiz, S. González, ... S. X. Deng in Biomarker Research

    Article Open access 31 May 2022
    

14. Single-cell analyses reveal transient retinal progenitor cells in the ciliary margin of develo** human retina

    The emergence of retinal progenitor cells and differentiation to various retinal cell types represent fundamental processes during retinal...

    Birthe Dorgau, Joseph Collin, ... Majlinda Lako in Nature Communications

    Article Open access 26 April 2024
    

15. Single-cell gene and isoform expression analysis reveals signatures of ageing in haematopoietic stem and progenitor cells

    Single-cell approaches have revealed that the haematopoietic hierarchy is a continuum of differentiation, from stem cell to committed progenitor,...

    Laura Mincarelli, Vladimir Uzun, ... Iain C. Macaulay in Communications Biology

    Article Open access 24 May 2023
    

16. Hematopoietic Stem and Progenitor Cell Identification and Transplantation in Zebrafish

    The zebrafish as a model organism is well known for its versatile genetics, rapid development, and straightforward live imaging. It is an excellent...

    Ellen Fraint, Peng Lv, ... Owen J. Tamplin in Hematopoietic Stem Cells

    Protocol 2023
    

17. Baf-mediated transcriptional regulation of teashirt is essential for the development of neural progenitor cell lineages

    Accumulating evidence hints heterochromatin anchoring to the inner nuclear membrane as an upstream regulatory process of gene expression. Given that...

    Byung Su Ko, Myeong Hoon Han, ... Sung Bae Lee in Experimental & Molecular Medicine

    Article Open access 19 February 2024
    

18. Small volume bone marrow aspirates with high progenitor cell concentrations maximize cell therapy dose manufacture and substantially reduce donor hemoglobin loss

    Background

    Bone marrow (BM) transplantation is a life-saving therapy for hematological diseases, and the BM harbors also highly useful (progenitor)...

    Jeremy Epah, Gabriele Spohn, ... Richard Schäfer in BMC Medicine

    Article Open access 19 September 2023
    

19. Cell-type-specific consequences of mosaic structural variants in hematopoietic stem and progenitor cells

    The functional impact and cellular context of mosaic structural variants (mSVs) in normal tissues is understudied. Utilizing Strand-seq, we sequenced...

    Karen Grimes, Hyobin Jeong, ... Jan O. Korbel in Nature Genetics

    Article Open access 28 May 2024
    

20. Hematopoietic stem and progenitor cell membrane-coated vesicles for bone marrow-targeted leukaemia drug delivery

    Leukemia is a kind of hematological malignancy originating from bone marrow, which provides essential signals for initiation, progression, and...

    **xin Li, Honghui Wu, ... Pengxu Qian in Nature Communications

    Article Open access 07 July 2024