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Population pharmacokinetic modeling of levodropropizine: extended application to comparative analysis between commercial formulations and exploration of pharmacokinetic effects of diet
Levodropropizine, a nonopioid antitussive agent, is being increasingly used in clinical practice with the development of several formulations for...
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Clinical Pharmacokinetic Studies
Drug efficacy and response are a function of drug concentration over time. In clinical pharmacokinetic studies, aspects of drug absorption,...
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Effect of massive ascites on ramucirumab pharmacokinetics in patients with gastrointestinal cancers: a population pharmacokinetic analysis
PurposeConsiderable amounts of injected immunoglobulin G-based therapeutic monoclonal antibodies, such as ramucirumab, are distributed into ascites....
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Population Pharmacokinetic Analysis of Dorzagliatin in Healthy Subjects and Patients with Type 2 Diabetes Mellitus
Background and ObjectivesDorzagliatin is a first-in-class small molecule glucokinase activator (GKA) that improves pancreatic insulin secretion...
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Compartmental Pharmacokinetic Models
Pharmacokinetic modeling is a tool that helps drug developers, clinicians, and health care professionals in general to understand and/or predict the...
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Escitalopram and Sertraline Population Pharmacokinetic Analysis in Pediatric Patients
Background and ObjectiveEscitalopram and sertraline are commonly prescribed for anxiety and depressive disorders in children and adolescents. The...
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Population pharmacokinetic analyses of methotrexate in pediatric patients: a systematic review
Background and objectivesMethotrexate is widely utilized in the chemotherapy of malignant tumors and autoimmune diseases in the pediatric population,...
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Dosage Optimization of Digoxin in Older Patients with Heart Failure and Chronic Kidney Disease: A Population Pharmacokinetic Analysis
BackgroundRenal function is an important index for digoxin dose adjustment, especially in patients with chronic kidney disease (CKD). Decreased...
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A Population Pharmacokinetic Analysis of l-Glutamine Exposure in Patients with Sickle Cell Disease: Evaluation of Dose and Food Effects
Background and Objectivel -Glutamine is a treatment for children and adults with sickle cell disease. A comprehensive evaluation of the...
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Population Pharmacokinetic Analysis for Model-Based Therapeutic Drug Monitoring of Tacrolimus in Chinese Han Heart Transplant Patients
Background and ObjectiveTacrolimus has become the first-line immunosuppressant for preventing rejection after heart transplantation. The present...
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Evolution of Ritlecitinib Population Pharmacokinetic Models During Clinical Drug Development
BackgroundRitlecitinib is an oral Janus kinase 3/tyrosine kinase expressed in hepatocellular carcinoma family inhibitor undergoing parallel clinical...
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External Evaluation of Population Pharmacokinetic Models of Piperacillin in Preterm and Term Patients from Neonatal Intensive Care
Background and ObjectivesPiperacillin/tazobactam is extensively used off-label to treat late-onset neonatal sepsis, but safety and pharmacokinetic...
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Pooled Population Pharmacokinetic Analysis for Exploring Ciprofloxacin Pharmacokinetic Variability in Intensive Care Patients
Background and ObjectivePrevious pharmacokinetic (PK) studies of ciprofloxacin in intensive care (ICU) patients have shown large differences in...
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Population Pharmacokinetic Analysis to Support and Facilitate Switching from Risperidone Formulations to Rykindo in Patients with Schizophrenia
IntroductionRYKINDO® (Rykindo) is a novel, long-acting injectable risperidone formulation administered biweekly (Q2W) through intramuscular gluteal...
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Predictive performance of population pharmacokinetic models of imatinib in chronic myeloid leukemia patients
Background and aimChronic myeloid leukemia is a myeloproliferative neoplasm associated with the specific chromosomal translocation known as the...
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External validation of population pharmacokinetic models of tacrolimus in Thai adult liver transplant recipients
ObjectiveSeveral population pharmacokinetic models of tacrolimus in liver transplant patients were built, and their predictability was evaluated in...
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Population pharmacokinetic analysis of lopinavir in HIV negative individuals exposed to SARS-CoV-2: a COPEP (COronavirus Post-Exposure Prophylaxis) sub-study
BackgroundLopinavir/ritonavir (LPV/r) is a drug traditionally used for the treatment of HIV that has been repurposed as a potential post-exposure...
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Population pharmacokinetic modeling of multiple-dose intravenous fosfomycin in critically ill patients during continuous venovenous hemodialysis
The aim of this study was to investigate the pharmacokinetics of multiple-dose intravenous (i.v.) fosfomycin in critically ill patients during...
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Predictive Performance of Population Pharmacokinetic Models for Amikacin in Term Neonates
Background and ObjectiveAmikacin is preferred in treating Gram-negative infections in neonates and it has a narrow therapeutic window. The population...
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Population Pharmacokinetic Analysis of Vancomycin in Patients with Solid or Hematological Malignancy in Relation to the Quick Sequential Organ Failure Assessment Scores
Background and ObjectiveIt remains unclear whether sepsis in patients with malignancy interferes with the predictive performance of the...
