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Plasma Cell Dyscrasias: Multiple Myeloma and Precursors
Multiple myeloma is a plasma cell dyscrasia that affects primarily the bone marrow by infiltration and replacement of normal hematopoietic marrow....
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The exploration of B cell maturation antigen expression in plasma cell dyscrasias beyond multiple myeloma
BackgroundB cell maturation antigen (BCMA) targeted immunotherapies have demonstrated remarkable clinical efficacy in multiple myeloma (MM). Here, we...
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Stem Cell Transplant for Plasma Cell Dyscrasias
Multiple myeloma is a malignancy of plasma cells which are post-germinal center terminally differentiated B lymphocytes. The patients commonly...
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Correlation of plasma cell assessment by phenotypic methods and molecular profiles by NGS in patients with plasma cell dyscrasias
BackgroundNext-generation sequencing (NGS) detects somatic mutations in a high proportion of plasma cell dyscrasias (PCD), but is currently not...
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The role of therapeutic plasma exchange in plasma cell disorders
Therapeutic plasma exchange (TPE) is an extracorporeal technique where patient’s plasma containing pathogenic substances is separated and removed...
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Enhancing prognostic power in multiple myeloma using a plasma cell signature derived from single-cell RNA sequencing
Multiple myeloma (MM) is a heterogenous plasma cell malignancy, for which the established prognostic models exhibit limitations in capturing the full...
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Characteristics and outcomes of COVID-19 in patients with plasma cell dyscrasias during the first Omicron wave in Bei**g since December 2022: a retrospective study at a National Clinical Research Center for Hematologic Disease
The wave of coronavirus disease 2019 (COVID-19) with Omicron variant reached its first peak in Bei**g, China in December 2022. We delineated...
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Quantitative and qualitative assessment of plasma cell dyscrasias in dual-layer spectral CT
ObjectivesVirtual non-calcium (VNCa) images could improve assessment of plasma cell dyscrasias by enhancing visibility of bone marrow. Thus, VNCa...
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Improved Outcome of Primary Plasma Cell Leukemia in the Current Era with the Use of Novel Agents and Autologous Bone Marrow Transplants—A Single Centre Experience
Primary Plasma cell leukemia (pPCL) is an aggressive variant of plasma cell dyscrasias. Diagnostic criteria of plasma cell leukemia were recently...
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Drug-Induced Blood Dyscrasias
Drug-induced hematological disorders though rare have long been an impending risk of modern pharmacotherapy. They can be life-threatening at times....
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Primary plasma cell leukemia: consensus definition by the International Myeloma Working Group according to peripheral blood plasma cell percentage
Primary plasma cell leukemia (PCL) has a consistently ominous prognosis, even after progress in the last decades. PCL deserves a prompt...
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Triclonal Gammopathy in Multiple Myeloma with Bleeding Diathesis: A Case Report
IntroductionGammopathies have clinical and diagnostic significance for lymphoproliferative disorders and plasma cell dyscrasias such as multiple...
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Short Research Communication Anti-Spike Antibody Response to COVISHIELD™ (SII-ChAdOx1 nCoV-19) Vaccine in Patients with B-Cell and Plasma Cell Malignancies and Hematopoietic Cell Transplantation Recipients
IntroductionThere is limited data on the serologic antibody responses after the ChAdOx1 vaccine in patients with hematological malignancies and...
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Idiopathic Lympho-Plasma Cellular Mucositis; A Diagnostic Predicament
The term “idiopathic lymphoplasmacellular mucositis” (ILPM) refers to a set of conditions marked by extensive lymphocyte and plasma cell infiltrates...
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Non-invasive prenatal test identifies circulating cell-free DNA chromosomal abnormalities derived from clonal hematopoiesis in aggressive hematological malignancies
Liquid biopsy is a minimally invasive diagnostic tool for identification of tumor-related mutations in circulating cell-free DNA (cfDNA). The aim of...
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Interleukin-6 Blockade with Tocilizumab in Idiopathic Multicentric Plasma Cell Variant Castleman Disease: Case Report
Castleman disease represents a group of rare lymphoproliferative disorders with heterogeneous manifestations and similar histopathological features....
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AL Lambda Amyloidosis Activates Acute Liver Failure in the Absence of Plasma Cell Dyscrasia
A patient with systemic amyloidosis developed portal hypertension, acute liver failure and multiorgan dysfunction. Extensive testing was unrevealing...
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Pain Syndromes of Hematologic Malignancies
Despite significant advances in the therapeutic options and prognoses of hematologic malignancies (HM), pain remains a significant complication that...
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Downregulation of ITGA6 confers to the invasion of multiple myeloma and promotes progression to plasma cell leukaemia
BackgroundSecondary plasma cell leukaemia (sPCL) is an aggressive form of multiple myeloma (MM), but the mechanism underlying MM progresses into PCL...
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Plasma Cell Neoplasms (Including Plasma Cell Myeloma)
Plasma cell neoplasms (also known as plasma cell dyscrasias) are diseases in which abnormal plasma cells proliferate and form tumors in the bones or...