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Increasing dopamine synthesis in nigrostriatal circuits increases phasic dopamine release and alters dorsal striatal connectivity: implications for schizophrenia
One of the most robust neurochemical abnormalities reported in patients with schizophrenia is an increase in dopamine (DA) synthesis and release,...
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Synaptotagmin-1-dependent phasic axonal dopamine release is dispensable for basic motor behaviors in mice
In Parkinson’s disease (PD), motor dysfunctions only become apparent after extensive loss of DA innervation. This resilience has been hypothesized to...
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Enhanced cognitive flexibility and phasic striatal dopamine dynamics in a mouse model of low striatal tonic dopamine
The catecholamine neuromodulators dopamine and norepinephrine are implicated in motor function, motivation, and cognition. Although roles for...
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Action and Interaction of Amyloid-β and Insulin on Dopamine Release and Reuptake in the Dorsal Lateral Striatum of Rats
AbstractAccumulation of amyloid-β (Aβ) in the brain is an important link in the pathogenesis of Alzheimer's disease. Experimental studies show that...
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The Impact of Temperature on the Formation, Release Mechanism, and Degradation of PLGA-based In-Situ Forming Implants
This study explores the impact of varying temperatures on the release behavior of Triptorelin Acetate (TA) from a PLGA-based in-situ forming implant...
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Bioinspired bi-phasic 3D nanoflowers of MgO/Mg(OH)2 coated melamine sponge as a novel bactericidal agent
By roughly mimicking the surface architectural design of dragonfly wings, novel bi-phasic 3D nanoflowers of MgO/Mg(OH) 2 were successfully synthesized...
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Phasic firing of dopaminergic neurons in the ventral tegmental area triggers peripheral immune responses
Dopaminergic neurons in the ventral tegmental area (VTA) play a crucial role in the processing of reward-related information. Recent studies with...
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Mechanisms underlying spontaneous phasic contractions and sympathetic control of smooth muscle in the rat caudal epididymis
Here we investigate mechanisms underlying spontaneous phasic contractions (SPCs) and sympathetic control of contractility in the rat epididymis, a...
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β-Amyloid and Lithium Affect the Magnitude of Phasic Dopamine Release in the Shell of the Nucleus Accumbens
Published data indicate that impairments to dopaminergic secretion in the shell of the nucleus accumbens play a role in the pathogenesis of...
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Left atrium phasic impairments in paroxysmal atrial fibrillation patients assessed by cardiovascular magnetic resonance feature tracking
Atrial fibrillation (AF) is an abnormal and irregular heartbeat caused by uncoordinated electrical impulses in the left atrium (LA), which could...
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Quantifying fat zonation in liver lobules: an integrated multiscale in silico model combining disturbed microperfusion and fat metabolism via a continuum biomechanical bi-scale, tri-phasic approach
Metabolic zonation refers to the spatial separation of metabolic functions along the sinusoidal axes of the liver. This phenomenon forms the...
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Interactions of calmodulin kinase II with the dopamine transporter facilitate cocaine-induced enhancement of evoked dopamine release
Typical and atypical dopamine uptake inhibitors (DUIs) prefer distinct conformations of the dopamine transporter (DAT) to form ligand-transporter...
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Imaging Neuropeptide Release at Drosophila Neuromuscular Junction with a Genetically Engineered Neuropeptide Release Reporter
Despite the important roles of neuropeptides in a variety of physiological processes, there still lacks a method to probe neuropeptide release events...
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Phasic pupillary responses modulate object-based attentional prioritization
Visual attention studies have demonstrated that the shape of space-based selection can be governed by salient object contours: when a portion of an...
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Pharmacological evaluation of the gabapentin salicylaldehyde derivative, gabapentsal, against tonic and phasic pain models, inflammation, and pyrexia
Gabapentinoids are effective drugs in most animal models of pain and inflammation with variable effects in humans. The current study evaluated the...
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Norepinephrine release in the cerebellum contributes to aversive learning
The modulation of dopamine release from midbrain projections to the striatum has long been demonstrated in reward-based learning, but the synaptic...
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A chemogenetic approach for dopamine imaging with tunable sensitivity
Genetically-encoded dopamine (DA) sensors enable high-resolution imaging of DA release, but their ability to detect a wide range of extracellular DA...
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Potassium Permanganate–Based Controlled Release Beads to Remediate Groundwater Pollution: Alkylbenzene Degradation and Permanganate Release Kinetics
Groundwater pollution is a significant threat to the public health and environment. Existing groundwater remedial approaches include ex situ...
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Amyloid-β42 stimulated hippocampal lactate release is coupled to glutamate uptake
Since brain glucose hypometabolism is a feature of Alzheimer’s disease (AD) progression, lactate utilization as an energy source may become critical...
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What does dopamine release reveal about latent inhibition?
A recent paper by Kutlu et al. (
2022 ) argues that changes in dopamine release during stimulus pre-exposure reflect non-associative changes in...