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SLC27A2 mediates FAO in colorectal cancer through nongenic crosstalk regulation of the PPARs pathway
BackgroundPeroxisome proliferator activated receptors ( PPARs ) are a nuclear hormone receptors superfamily that is closely related to fatty acid (FA)...
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Multi-regulator of EZH2-PPARs Therapeutic Targets: A Hallmark for Prospective Restoration of Pancreatic Insulin Production and Cancer Dysregulation
The unexpected rise in cancer and diabetes statistics has been a significant global threat, inciting ongoing research into various biomarkers that...
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PPARs and Their Emerging Role in Vascular Biology, Inflammation and Atherosclerosis
Peroxisome proliferator-activated receptors (PPARs) are powerful, ligand-activated, steroid hormone DNA-binding receptors that determine...
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Effect of Galactooligosaccharide on PPARs/PI3K/Akt Pathway and Gut Microbiota in High-Fat and High-Sugar Diet Combined with STZ-Induced GDM Rat Model
Gestational diabetes mellitus (GDM) is a metabolic disorder, characterized by underlying glucose intolerance, diabetes onset or first diagnosis...
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Targeting PPARs Signaling Pathways in Cardiotoxicity by Natural Compounds
Cardiotoxicity can be a complication of both drugs and a variety of other chemicals that affects morbidity, quality of life, and even mortality. The...
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Effects of active, inactive, and derivatives of Akkermansia muciniphila on the expression of the endocannabinoid system and PPARs genes
This study aimed to investigate the effects of active and heat-inactivated forms of Akkermansia muciniphila , bacterium-derived outer membrane...
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Therapeutic Potential of PPARs in Alzheimer’s Disease
Alzheimer’s disease (AD) is the most leading cause of dementia, characterized by the accumulation of amyloid beta (Aβ) plaques in the brain, leading...
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A dietary anthocyanin cyanidin-3-O-glucoside binds to PPARs to regulate glucose metabolism and insulin sensitivity in mice
We demonstrate the mechanism by which C3G, a major dietary anthocyanin, regulates energy metabolism and insulin sensitivity. Oral administration of...
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Rubus chingii var. suavissimus alleviates high-fat diet-induced lipid metabolism disorder via modulation of the PPARs/SREBP pathway in Syrian golden hamsters
While the underlying mechanism remains unknown, Rubus chingii var. suavissimus (S. K. Lee) L. T. Lu or Rubus suavissimus S. Lee (RS), a sweet plant...
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Unlocking new avenues for neuropsychiatric disease therapy: the emerging potential of Peroxisome proliferator-activated receptors as promising therapeutic targets
RationalePeroxisome proliferator-activated receptors (PPARs) are transcription factors that regulate various physiological processes such as...
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The Strategy of Targeting Peroxisome Proliferator-Activated Receptor (PPAR) in the Treatment of Neuropsychiatric Disorders
Peroxisome proliferator-activated receptors (PPARs) are nonsteroid nuclear receptors and transcription factors that regulate several...
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Perfluoroalkyl Substances (PFAS) and Their Effects on the Placenta, Pregnancy, and Child Development: a Potential Mechanistic Role for Placental Peroxisome Proliferator–Activated Receptors (PPARs)
Purpose of ReviewThis review summarizes studies highlighting perfluoroalkyl substances (PFAS) and their effects on the placenta, pregnancy outcomes,...
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Genome-wide identification and expression of the peroxisome proliferator-activated receptor gene family in the Tibetan highland fish Gymnocypris przewalskii
Peroxisome proliferator-activated receptor (PPAR) plays an important role in the regulation of lipid metabolism and has been widely identified in...
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Leptin signaling in breast cancer and its crosstalk with peroxisome proliferator-activated receptors α and γ
Obesity may create a mitogenic microenvironment that influences tumor initiation and progression. The obesity-associated adipokine, leptin regulates...
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Targeting lipid-sensing nuclear receptors PPAR (α, γ, β/δ): HTVS and molecular docking/dynamics analysis of pharmacological ligands as potential pan-PPAR agonists
The global prevalence of obesity-related systemic disorders, including non-alcoholic fatty liver disease (NAFLD), and cancers are rapidly rising....
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The cross-talk between leptin and circadian rhythm signaling proteins in physiological processes: a systematic review
BackgroundToday, modern lifestyles and disrupted sleep patterns cause circadian clock rhythm impairments that are associated with altered leptin...
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The effect of Faecalibacterium prausnitzii and its extracellular vesicles on the permeability of intestinal epithelial cells and expression of PPARs and ANGPTL4 in the Caco-2 cell culture model
Background and Objectives:Gut microbiota such as Faecalibacterium prausnitzii play a major role in the regulation of gut barrier, inflammation and...
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The PPAR System in Diabetes
Peroxisome proliferative activated receptors (PPARs) act as ligand-activated transcription factors involved in glucose and lipoprotein metabolism,...
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Ligand dependent interaction between PC-TP and PPARδ mitigates diet-induced hepatic steatosis in male mice
Phosphatidylcholine transfer protein (PC-TP; synonym StarD2) is a soluble lipid-binding protein that transports phosphatidylcholine (PC) between...
