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1. Porcine promyelocytic leukemia protein isoforms suppress Japanese encephalitis virus replication in PK15 cells

   Background

   Promyelocytic leukemia protein (PML) is a primary component of PML nuclear bodies (PML-NBs). PML and PML-NBs play critical roles in...

   Zhenyu Chen, Huai** Liu, ... Songbai Yang in Virology Journal

   Article Open access 29 November 2023
   

2. Building in vitro tools for livestock genomics: chromosomal variation within the PK15 cell line

   Background

   Cultured porcine cell lines are powerful tools for functional genomics and in vitro phenotypic testing of candidate causal variants....

   M. Johnsson, J. M. Hickey, M. K. Jungnickel in BMC Genomics

   Article Open access 11 January 2024
   

3. Genome-wide analysis of long noncoding RNA profiles in pseudorabies-virus-infected PK15 cells

   Recently, an increasing number of studies have shown that long noncoding RNAs (lncRNAs) are involved in host metabolism after infection with...

   Jian-guo Dong, Ming-rui Chen, ... Lei Na in Archives of Virology

   Article 05 September 2023
   

4. Low molecular weight sulfated chitosan efficiently reduces infection capacity of porcine circovirus type 2 (PCV2) in PK15 cells

   Background

   Porcine circovirus type 2 (PCV2)-associated diseases are a major problem for the swine industry worldwide. In addition to vaccines, the...

   Daniela Jiménez-Arriagada, Alejandro A. Hidalgo, ... Sergio A. Bucarey in Virology Journal

   Article Open access 24 March 2022
   

5. PK15 cell line stably overexpressing IL2 enhances PCV2 replication

   Porcine circovirus type 2 (PCV2) is the primary agent responsible for porcine circovirus-associated diseases (PCVADs), which is acknowledged as one...

   Xuliang Zhang, Yingfeng Zhao, ... Jie Liu in Virus Genes

   Article 03 January 2021
   

6. Coinfection with PEDV and BVDV induces inflammatory bowel disease pathway highly enriched in PK-15 cells

   Background

   From the 1078 diarrhea stools tested in our survey from 2017 to 2020 in local area of China, PEDV was the key pathogen that was closely...

   **ghua Cheng, Jie Tao, ... Huili Liu in Virology Journal

   Article Open access 16 July 2022
   

7. Transcriptomic analysis reveals impact of gE/gI/TK deletions on host response to PRV infection

   Background

   Pseudorabies virus (PRV) causes substantial losses in the swine industry worldwide. Attenuated PRV strains with deletions of...

   **aoli Wang, Yingguang Li, ... Hongliang Zhang in Virology Journal

   Article Open access 19 December 2023
   

8. Thallium Toxicity and its Interference with Potassium Pathways Tested on Various Cell Lines

   Thallium (Tl) is a highly toxic heavy metal whose mechanism of toxicity is still not completely understood. The aim of this study was to test Tl...

   Ana Marija Marjanović Čermak, Stipe Mustać, ... Ana-Marija Domijan in Biological Trace Element Research

   Article 13 February 2024
   

9. Genome-wide identification of functional enhancers and their potential roles in pig breeding

   Background

   The pig is an economically important livestock species and is a widely applied large animal model in medical research. Enhancers are...

   Yinqiao Wu, Yuedong Zhang, ... Ya** Zhang in Journal of Animal Science and Biotechnology

   Article Open access 04 July 2022
   

10. Isolation and genetic analysis of Porcine circovirus 2 in southern India evidences high circulation of Porcine circovirus 2d genotype

    Background

    Porcine circovirus 2 is globally noted swine pathogen with multiple genotypes associated with vast clinical and subclinical outcomes. This...

    S. Parthiban, A. Ramesh, ... Chintu Ravishankar in Molecular Biology Reports

    Article 10 October 2022
    

11. Resistance to pseudorabies virus by knockout of nectin1/2 in pig cells

    Pseudorabies virus (PRV) is a pig pathogen that causes substantial economic losses to the pig industry. Infection of host cells by PRV is mediated by...

    Yaoqiang Huang, Zicong Li, ... Huaqiang Yang in Archives of Virology

    Article 06 October 2020
    

12. Identification of miR-192 target genes in porcine endometrial epithelial cells based on miRNA pull-down

    Introduction

    MicroRNAs (miRNAs)—a class of small endogenous non-coding RNAs—are widely involved in post-transcriptional gene regulation of numerous...

    Qingchun Li, Ruonan Gao, ... Tao Huang in Molecular Biology Reports

    Article 14 March 2023
    

13. GADD34-mediated dephosphorylation of eIF2α facilitates pseudorabies virus replication by maintaining de novo protein synthesis

    Viruses have evolved multiple strategies to manipulate their host’s translational machinery for the synthesis of viral proteins. A common viral...

    Ting Zhu, Xueli Jiang, ... Baomin Qi in Veterinary Research

    Article Open access 20 December 2021
    

14. Truncated Rep protein of porcine circovirus 2 (PCV2) caused by a naturally occurring mutation reduced virus replication in PK15 cells

    Background

    Porcine circovirus 2 (PCV2) is the causative agent of porcine circovirus-associated diseases (PCVADs). The infection of PCV2 is widespread...

    Yi Hu, **ong Cai, ... Aibing Wang in BMC Veterinary Research

    Article Open access 15 July 2019
    

15. Molecular evidence of porcine circovirus 3 infection in swine: first report in southern India

    The present study examined 434 field samples including serum (n = 273), swabs from natural orifices (n = 52) and postmortem tissue samples (n = 109)...

    S. Parthiban, A. Ramesh, ... D. Balasubramaniyam in VirusDisease

    Article 25 July 2022
    

16. Cell-Based Biosensor to Visualize Nitric Oxide Release from Living Cells for Toxicity Assessment

    Fluorescence imaging provides a powerful technique to observe biomolecular dynamics in living systems, if fluorescent biosensors for the relevant...

    Moritoshi Sato, Yoshio Umezawa in Toxicity Assessment

    Protocol 2021
    

17. Integrated analysis of microRNA and messenger RNA expression profiles reveals functional microRNA in infectious bovine rhinotracheitis virus-induced mitochondrial damage in Madin-Darby bovine kidney cells

    Background

    Studies have confirmed that Infectious bovine rhinotracheitis virus (IBRV) infection induces mitochondrial damage. MicroRNAs (miRNAs) are a...

    Yingcai Ma, Xue** Guo, ... Xuelian Ma in BMC Genomics

    Article Open access 08 February 2024
    

18. Host Interferon-Stimulated Gene 20 Inhibits Pseudorabies Virus Proliferation

    Host interferon-stimulated gene 20 (ISG20) exerts antiviral effects on viruses by degrading viral RNA or by enhancing IFN signaling. Here, we...

    **aoyong Chen, Dage Sun, ... Guangzhi Tong in Virologica Sinica

    Article 08 April 2021
    

19. Isolation and artificial production of atypical porcine pestivirus, using the swine-kidney-derived cell line SK-L

    Congenital tremor (CT) in piglets was first reported in 1922, and although the causative pathogen was unknown for many years, atypical porcine...

    Mai Shiokawa, Yui Morita, ... Hiroshi Aoki in Archives of Virology

    Article 19 November 2023
    

20. Design of fusion protein for efficient preparation of cyanovirin-n and rapid enrichment of pseudorabies virus

    Objective

    Cyanovirin-N (CVN) is a cyanobacterial protein with potent neutralizing activity against enveloped virus. To achieve the economic and...

    Bin Wang, Zhi Yang, ... **aolan Yu in Biotechnology Letters

    Article 09 May 2021