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rs822336 binding to C/EBPβ and NFIC modulates induction of PD-L1 expression and predicts anti-PD-1/PD-L1 therapy in advanced NSCLC
Efficient predictive biomarkers are needed for immune checkpoint inhibitor (ICI)-based immunotherapy in non-small cell lung cancer (NSCLC). Testing...
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An alternatively spliced PD-L1 isoform PD-L1∆3, and PD-L2 expression in breast cancers: implications for eligibility scoring and immunotherapy response
Targeting PD-1/PD-L1 has shown substantial therapeutic response and unprecedented long-term durable responses in the clinic. However, several...
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Development of small-molecular-based radiotracers for PET imaging of PD-L1 expression and guiding the PD-L1 therapeutics
PurposeProgrammed cell death protein ligand 1 (PD-L1) is a crucial biomarker for immunotherapy. However, nearly 70% of patients do not respond to...
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Exploratory analyses of treatment subgroup interaction by PD-L1 status and according to PD-L1 expression in the JAVELIN Bladder 100 trial
PurposePost hoc analysis of the JAVELIN Bladder 100 trial of avelumab maintenance in locally advanced/metastatic urothelial carcinoma (la/mUC) to...
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Factors correlating the expression of PD-L1
ObjectivePD-L1 was an important biomarker in lung adenocarcinoma. The study was to confirm the most important factor affecting the expression of...
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MIIP downregulates PD-L1 expression through HDAC6 in cutaneous melanoma
PurposeImmune checkpoint inhibitors have improved the objective response rate and survival of melanoma patients. However, there are still many...
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Scoring PD-L1 Expression in Urothelial Carcinoma: An International Multi-Institutional Study on Comparison of Manual and Artificial Intelligence Measurement Model (AIM-PD-L1) Pathology Assessments
Assessing programmed death ligand 1 (PD-L1) expression on tumor cells (TCs) using Food and Drug Administration-approved, validated immunoassays can...
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NUP43 promotes PD-L1/nPD-L1/PD-L1 feedback loop via TM4SF1/JAK/STAT3 pathway in colorectal cancer progression and metastatsis
Programmed cell death-ligand 1 (PD-L1) has a significant role in tumor progression and metastasis, facilitating tumor cell evasion from immune...
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Role of stromal PD-L1 expression in colorectal liver metastasis
Background and AimThe outcomes of immune checkpoint blockade for colorectal cancer (CRC) treatment are unsatisfactory. Furthermore, the efficacy of...
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KEAP1 promotes anti-tumor immunity by inhibiting PD-L1 expression in NSCLC
Immunotherapy has become a prominent first-line cancer treatment strategy. In non-small cell lung cancer (NSCLC), the expression of PD-L1 induces an...
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IGFBP3 induces PD-L1 expression to promote glioblastoma immune evasion
BackgroundGlioblastoma (GBM) characterized by immune escape is the most malignant primary brain tumors, which has strong immunosuppressive effect....
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Assessing PD-L1 Expression in Different Tumor Types
The assessment of PD-L1 immunohistochemical staining in cytology and especially tissue samples is one of the tasks a pathologist must undertake in...
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PD-L1 Expression in Colorectal Carcinoma Correlates with the Immune Microenvironment
Introduction/BackgroundColorectal carcinoma (CRC) is a common malignancy, with its diverse clinical, pathological, and molecular features. The immune...
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PD-L1 Expression in Nonbacterial Chronic Cystitis and Bladder Cancer
Introduction and hypothesisThe objective was to assess PD-L1 expression in nonbacterial chronic cystitis (NCC) and bladder cancer (BC).
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PD-L1 expression in ovarian clear cell carcinoma using the 22C3 pharmDx assay
BackgroundOvarian clear cell carcinoma (OCCC), well known for its chemoresistance to platinum-based chemotherapy, exhibited a good response in...
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Cell fusion upregulates PD-L1 expression for evasion from immunosurveillance
MSCs (mesenchymal stem cells), responsible for tissue repair, rarely undergo cell fusion with somatic cells. Here, we show that ~5% of bladder cancer...
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FAT10 induces immune suppression by upregulating PD-L1 expression in hepatocellular carcinoma
The upregulation of programmed death ligand 1 (PD-L1) plays a crucial role in facilitating cancer cells to evade immune surveillance through...
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LncTUG1 promotes hepatocellular carcinoma immune evasion via upregulating PD-L1 expression
HCC is one of the most common malignant tumors worldwide. Although traditional treatment methods have been improved in recent years, the survival...
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Correlation of PD-1 and PD-L1 expression in oral leukoplakia and oral squamous cell carcinoma: an immunohistochemical study
The programmed cell death protein (PD-1)/programmed cell death protein ligand (PD-L1) pathway and cytotoxic T lymphocyte antigen are the most...
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Impact of glucose metabolism on PD-L1 expression in sorafenib-resistant hepatocellular carcinoma cells
Hepatocellular carcinoma (HCC) is the fifth leading cause of cancer-related mortality worldwide. Programmed cell death ligand-1 (PD-L1) is an immune...
