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Minimalist “in situ” tumor vaccine leveraging versatile dendrimer nanoplatform coordinated ICD and immunoagonist for boosted chemoimmunotherapy
As a burgeoning combination tactic, cancer chemoimmunotherapy has brightened up the potential possibility of conventional chemotherapy by virtue of...
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Development of finely tuned liposome nanoplatform for macrophage depletion
BackgroundImmunotherapy with clodronate-encapsulated liposomes, which induce macrophage depletion, has been studied extensively. However, previously...
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Surface curvature-induced oriented assembly of sushi-like Janus therapeutic nanoplatform for combined chemodynamic therapy
BackgroundChemodynamic therapy (CDT) based on Fenton/Fenton-like reaction has emerged as a promising cancer treatment strategy. Yet, the strong...
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A multifunctional integrated biomimetic spore nanoplatform for successively overcoming oral biological barriers
The biological barriers have seriously restricted the efficacious responses of oral delivery system in diseases treatment. Utilizing a carrier based...
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Sertaconazole-repurposed nanoplatform enhances lung cancer therapy via CD44-targeted drug delivery
BackgroundLung cancer is one of the most frequent causes of cancer-related deaths worldwide. Drug repurposing and nano-drug delivery systems are...
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Near infrared II excitation nanoplatform for photothermal/chemodynamic/antibiotic synergistic therapy combating bacterial biofilm infections
Drug-resistant bacterial biofilm infections (BBIs) are refractory to elimination. Near-infrared-II photothermal therapy (NIR-II PTT) and chemodynamic...
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Laser-activatable oxygen self-supplying nanoplatform for efficiently overcoming colorectal cancer resistance by enhanced ferroptosis and alleviated hypoxic microenvironment
BackgroundColorectal cancer (CRC) is the second most deadly cancer worldwide, with chemo-resistance remaining a major obstacle in CRC treatment....
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Osteosarcoma-targeted Cu and Ce based oxide nanoplatform for NIR II fluorescence/magnetic resonance dual-mode imaging and ros cascade amplification along with immunotherapy
BackgroundAs the lethal bone tumor, osteosarcoma often frequently occurs in children and adolescents with locally destructive and high metastasis....
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A novel ROS-Related chemiluminescent semiconducting polymer nanoplatform for acute pancreatitis early diagnosis and severity assessment
Acute pancreatitis (AP) is a common and potentially life-threatening inflammatory disease of the pancreas. Reactive oxygen species (ROS) play a key...
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A nanoplatform self-assembled by coordination delivers siRNA for lung cancer therapy
The high incidence and mortality of lung cancer have present threaten in front of people all over the world. Researches in clinical trials find that...
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Rational design of NIR-II molecule-engineered nanoplatform for preoperative downstaging and imaging-guided surgery of orthotopic hepatic tumor
Orthotopic advanced hepatic tumor resection without precise location and preoperative downstaging may cause clinical postoperative recurrence and...
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Tumor-penetrating nanoplatform with ultrasound “unlocking” for cascade synergistic therapy and visual feedback under hypoxia
BackgroundCombined therapy based on the effects of cascade reactions of nanoplatforms to combat specific solid tumor microenvironments is considered...
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Dual-targeted delivery of temozolomide by multi-responsive nanoplatform via tumor microenvironment modulation for overcoming drug resistance to treat glioblastoma
Glioblastoma (GBM) is the most aggressive primary brain tumor with low survival rate. Currently, temozolomide (TMZ) is the first-line drug for GBM...
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Microwave triggered multifunctional nanoplatform for targeted photothermal-chemotherapy in castration-resistant prostate cancer
Lacking a precise targeting strategy, castration-resistant prostate cancer (CRPC) is still hard to be treat effectively. Exploring treatment options...
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Inflammatory microenvironment regulation and osteogenesis promotion by bone-targeting calcium and magnesium repletion nanoplatform for osteoporosis therapy
Osteoporosis is the most common bone metabolic disease that affects the health of middle-aged and elderly people, which is hallmarked by imbalanced...
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High-temperature PTT/CDT coordination nanoplatform realizing exacerbated hypoxia for enhancing hypoxia-activated chemotherapy to overcome tumor drug resistance
BackgroundHypoxia-activated prodrugs present new opportunities for safe and effective tumor drug resistance therapy due to their high selectivity for...
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Ce6-modified Fe ions-doped carbon dots as multifunctional nanoplatform for ferroptosis and photodynamic synergistic therapy of melanoma
BackgroundDespite the higher sensitivity of melanoma towards ferroptosis and photodynamic therapy (PDT), the lack of efficient ferroptosis inducers...
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An Oxygen-Independent Photodynamic Therapy Nanoplatform for Combating Anaerobic Infection
Anaerobic bacteria infections remain a major threat to humans. Oxidative stress mediated by photodynamic therapy (PDT) has shown great potential in...
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Two-dimensional Nb2C-based nanoplatform augmented sonodynamic antibacterial therapy and bone regeneration
Rapid disinfection and promotion of bone regeneration are two crucial aspects of the clinical treatment of osteomyelitis. There is an urgent need to...
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Biodegradable FePS3 nanoplatform for efficient treatment of osteosarcoma by combination of gene and NIR-II photothermal therapy
As a common tumor with high incidence, osteosarcoma possesses extremely poor prognosis and high mortality. Improving the survival of osteosarcoma...
