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**nbao Pill ameliorates heart failure via regulating the SGLT1/AMPK/PPARα axis to improve myocardial fatty acid energy metabolism
BackgroundHeart failure (HF) is characterized by a disorder of cardiomyocyte energy metabolism. **nbao Pill (XBW), a traditional Chinese medicine...
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miR-1268a Regulates Fatty Acid Metabolism by Targeting CD36 in Angiotensin II-induced Heart Failure
Multiple RNAs have been involved in the progress of heart failure. However, the role of miR-1268a in heart failure is still unclear. The...
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Increased circulating uric acid aggravates heart failure via impaired fatty acid metabolism
BackgroundIncreased circulating uric acid (UA) concentration may disrupt cardiac function in heart failure patients, but the specific mechanism...
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Aldose reductase inhibition alleviates diabetic cardiomyopathy and is associated with a decrease in myocardial fatty acid oxidation
BackgroundCardiovascular diseases, including diabetic cardiomyopathy, are major causes of death in people with type 2 diabetes. Aldose reductase...
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Fasting increases susceptibility to acute myocardial ischaemia/reperfusion injury through a sirtuin-3 mediated increase in fatty acid oxidation
Fasting increases susceptibility to acute myocardial ischaemia/reperfusion injury (IRI) but the mechanisms are unknown. Here, we investigate the role...
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Inhibition of fatty acid uptake by TGR5 prevents diabetic cardiomyopathy
Diabetic cardiomyopathy is characterized by myocardial lipid accumulation and cardiac dysfunction. Bile acid metabolism is known to play a crucial...
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Dysregulated palmitic acid metabolism promotes the formation of renal calcium-oxalate stones through ferroptosis induced by polyunsaturated fatty acids/phosphatidic acid
The pathogenesis of renal calcium-oxalate (CaOx) stones is complex and influenced by various metabolic factors. In parallel, palmitic acid (PA) has...
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Bawei Chenxiang Wan ameliorates right ventricular hypertrophy in rats with high altitude heart disease by SIRT3-HIF1α-PDK/PDH signaling pathway improving fatty acid and glucose metabolism
BackgroundBawei Chenxiang Wan ( BCW ) is among the most effective and widely used therapies for coronary heart disease and angina pectoris in Tibet....
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MARK4 aggravates cardiac dysfunction in mice with STZ-induced diabetic cardiomyopathy by regulating ACSL4-mediated myocardial lipid metabolism
Diabetic cardiomyopathy is a specific type of cardiomyopathy. In DCM, glucose uptake and utilization are impaired due to insulin deficiency or...
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4-phenylbutyric acid improves sepsis-induced cardiac dysfunction by modulating amino acid metabolism and lipid metabolism via Comt/Ptgs2/Ppara
IntroductionCardiac dysfunction after sepsis the most common and severe sepsis-related organ failure. The severity of cardiac damage in sepsis...
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Myocardial Metabolism in Heart Failure
Purpose of ReviewMyocardial metabolism is intricately linked to cardiac function. Perturbations of cardiac energy metabolism result in an...
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Altered acylcarnitine metabolism and inflexible mitochondrial fuel utilization characterize the loss of neonatal myocardial regeneration capacity
Myocardial regeneration capacity declines during the first week after birth, and this decline is linked to adaptation to oxidative metabolism....
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Pharmacological Effects of Botanical Drugs on Myocardial Metabolism in Chronic Heart Failure
Although there have been significant advances in the treatment of heart failure in recent years, chronic heart failure remains a leading cause of...
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Dual roles of myocardial mitochondrial AKT on diabetic cardiomyopathy and whole body metabolism
BackgroundThe PI3K/AKT pathway transduces the majority of the metabolic actions of insulin. In addition to cytosolic targets, insulin-stimulated...
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Targeting Myocardial Substrate Metabolism in the Failing Heart: Ready for Prime Time?
Purpose of ReviewWe review the clinical benefits of altering myocardial substrate metabolism in heart failure.
Recent FindingsModulation of cardiac...
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The abnormalities of free fatty acid metabolism in patients with hypertrophic cardiomyopathy, a single-center retrospective observational study
BackgroundPrevious studies have shown the importance of energy deficiency and malfunctioning mitochondria in the pathophysiology of hypertrophic...
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Pancreatic fatty replacement as risk marker for altered glucose metabolism and cardiac iron and complications in thalassemia major
ObjectivesThis multicenter study assessed the extent of pancreatic fatty replacement and its correlation with demographics, iron overload, glucose...
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Serum metabolism characteristics of patients with myocardial injury after noncardiac surgery explored by the untargeted metabolomics approach
BackgroundMyocardial injury after noncardiac surgery (MINS) is one of the most common complications associated with postoperative adverse...
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Targeting fatty acid metabolism for fibrotic disorders
Fibrosis is defined by abnormal accumulation of extracellular matrix, which can affect virtually every organ system under diseased conditions....
