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Structure-based virtual screening against multiple Plasmodium falciparum kinases reveals antimalarial compounds
The continuous emergence of resistance against most frontline antimalarial drugs has led to countless deaths in malaria-endemic countries, counting...
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Hydroxychloroquine an Antimalarial Drug, Exhibits Potent Antifungal Efficacy Against Candida albicans Through Multitargeting
Candida albicans is the primary etiological agent associated with candidiasis in humans. Unrestricted growth of C. albicans can progress to systemic...
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Glycyrrhizin and boswellic acids, the golden nutraceuticals: multitargeting for treatment of mild–moderate COVID-19 and prevention of post-COVID cognitive impairment
Breakthrough infections have been reported in fully vaccinated persons. Furthermore, rebound symptoms have been reported following the new FDA...
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Polymeric magnetic nanoparticles: a multitargeting approach for brain tumour therapy and imaging
The most challenging task in targeting the brain is trespassing the blood–brain barrier (BBB) which restricts the movement of about 98% small...
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Probing the multitargeting potential of n-hexane fraction of Gongronema latifolium leaves in neurodegeneration via in vitro, GC–MS and in silico studies
BackgroundNeurodegenerative disorders (NDDs) are associated with increased activities of brain acetylcholinesterase (AChE), butyrylcholinesterase...
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Synergistic Herb-Drug Interactions Against Bacteria
Pharmacodynamic phytochemical/extract-antibiotic interactions can modify the efficacy of the antibiotic by reversal of antibiotic resistance...
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Synergistic Herb-Drug Interactions Against Viral Diseases
Emerging or reemerging viruses are of serious concern as they are associated with higher degree of mortality and deleterious impact on human life....
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Synergistic Herb Interactions with Anticancer Drugs
Cancer is emerging globally as one of the most important public health concerns. Lung, colorectal, prostate, stomach, and breast cancers account for...
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Multifunctional peptide conjugated amphiphilic cationic copolymer for enhancing ECs targeting, penetrating and nuclear accumulation
Gene therapy has drawn great attention in the treatments of many diseases, especially for cardiovascular diseases. However, the development of gene...
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Identification of FDA-approved drugs with triple targeting mode of action for the treatment of monkeypox: a high throughput virtual screening study
According to the Center for Disease Control and Prevention, as of August 23, 94 countries had confirmed 42,954 Monkeypox Virus cases. As specific...
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Versatile Structurally Diverse Natural Products and Their Semisynthetic Analogs as Potential Antileishmanial Drugs
Mortalities associated with leishmaniasis are skyrocketing at an alarming rate. Lack of vaccine for leishmaniasis treatment is making the fight...
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Drug Polypharmacology Toward Drug Repurposing
Polypharmacology has emerged as a new paradigm in drug discovery as several drugs exert their effects through interaction with multiple targets,...
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Polypharmacology and Natural Products
Natural products (NPs) play an important role in drug discovery. No less than 50% of the Food and Drug Administration (FDA)-approved drugs were NPs...
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Therapeutic Effects of Combination of Nebivolol and Donepezil: Targeting Multifactorial Mechanisms in ALS
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive loss of motor neurons in the spinal cord....
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Tumor Treating Fields (TTFields) combined with the drug repurposing approach CUSP9v3 induce metabolic reprogramming and synergistic anti-glioblastoma activity in vitro
BackgroundGlioblastoma represents a brain tumor with a notoriously poor prognosis. First-line therapy may include adjunctive Tumor Treating Fields...
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Molecular In Vitro and In Vivo Diagnostics as the Impartible Basis of Multimodal Therapy Approaches in Precision Oncology
In 2000, more than two decades ago, genome-wide gene expression profiling became available and thereafter led to the dissection of cancer biology...
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Advances in plant-derived natural products for antitumor immunotherapy
In recent years, immunotherapy has emerged as a novel antitumor strategy in addition to traditional surgery, radiotherapy and chemotherapy. It...
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Synergistic Herb-Drug Interactions Against Tuberculosis
Tuberculosis is an age-old disease that still torments the health system despite decades of vaccination and chemotherapeutic interventions. The...
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Memantine-Based Derivatives: Synthesis and Their Biological Evaluation
Alzheimer’s disease (AD) is a chronic neurological disorder characterized by memory loss and cognitive decline. It is a multifactorial disease, and a...
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A Cocktail of Natural Compounds Holds Promise for New Immunotherapeutic Potential in Head and Neck Cancer
ObjectiveTo obtain detailed understanding on the gene regulation of natural compounds in altering prognosis of head and neck squamous cell carcinomas...