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Lurcher Mouse
Lurcher mutant mouse is a natural model of hereditary cerebellar degeneration which is caused by a mutation in the δ2 glutamate receptor encoding...
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Mouse Models of Cell Cycle Regulators: New Paradigms
In yeast, a single cyclin-dependent kinase (Cdk) is able to regulate diverse cell cycle transitions (S and M phases) by associating with multiple...
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TRIM28 promotes luminal cell plasticity in a mouse model of prostate cancer
The Tripartite motif-containing 28 (TRIM28) transcriptional cofactor is significantly upregulated in high-grade and metastatic prostate cancers. To...
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Western Blot of Tau Protein from Mouse Brains Extracts: How to Avoid Signal Artifacts
Tau is a microtubule-associated protein enriched in the axonal compartment. Its most well-known function is to bind and stabilize microtubules. In...
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Automation at the service of the study of executive functions in preclinical models
Cognitive flexibility involves the capability to switch between different perspectives and implement novel strategies upon changed circumstances. The...
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Comparing mouse and human cingulate cortex organization using functional connectivity
The subdivisions of the extended cingulate cortex of the human brain are implicated in a number of high-level behaviors and affected by a range of...
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Mouse strain-specific polymorphic provirus functions as cis-regulatory element leading to epigenomic and transcriptomic variations
Polymorphic integrations of endogenous retroviruses (ERVs) have been previously detected in mouse and human genomes. While most are inert, a subset...
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Application of Cadherin cRNA Probes in Brains of Alzheimer’s Disease Mouse Model
AbstractThe cadherin superfamily molecules, functioning as cell adhesion molecules, are recognized to play roles in both physiological and...
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Genic constraint against nonsynonymous variation across the mouse genome
BackgroundSelective constraint, the depletion of variation due to negative selection, provides insights into the functional impact of variants and...
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In vivo affinity maturation of mouse B cells reprogrammed to express human antibodies
Mice adoptively transferred with mouse B cells edited via CRISPR to express human antibody variable chains could help evaluate candidate vaccines and...
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Mass spectrometry-based draft of the mouse proteome
The laboratory mouse ranks among the most important experimental systems for biomedical research and molecular reference maps of such models are...
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Advances in research of biological functions of Isthmin-1
Isthmin-1 (ISM1) was initially thought to be a brain secretory factor, but with the development of technical means of research and the refinement of...
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Biological Functions of the KDM2 Family of Histone Demethylases
The histone lysine demethylase 2 (KDM2) family of α-Ketoglutarate-Fe++-dependent dioxygenases were the first Jumonji-domain-containing proteins...
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Torn Between Love and Hate: Mouse Tracking Ambivalent Attitudes Towards Robots
Robots are a source of evaluative conflict and thus elicit ambivalence. In fact, psychological research has shown across domains that people...
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Role of RhoG as a regulator of cellular functions: integrating insights on immune cell activation, migration, and functions
BackgroundRhoG is a multifaceted member of the Rho family of small GTPases, sharing the highest sequence identity with the Rac subfamily members. It...
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Single cell transcriptome analysis of the THY-Tau22 mouse model of Alzheimer’s disease reveals sex-dependent dysregulations
Alzheimer’s disease (AD) progression and pathology show pronounced sex differences, but the factors driving these remain poorly understood. To gain...
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Species-specific metabolic reprogramming in human and mouse microglia during inflammatory pathway induction
Metabolic reprogramming is a hallmark of the immune cells in response to inflammatory stimuli. This metabolic process involves a switch from...
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A holistic view of mouse enhancer architectures reveals analogous pleiotropic effects and correlation with human disease
BackgroundEfforts to elucidate the function of enhancers in vivo are underway but their vast numbers alongside differing enhancer architectures make...
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Context-specific functions of chromatin remodellers in development and disease
Chromatin remodellers were once thought to be highly redundant and nonspecific in their actions. However, recent human genetic studies demonstrate...
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Computational immunohistochemical map** adds immune context to histological phenotypes in mouse models of colitis
Inflammatory bowel disease (IBD) is characterized by chronic, dysregulated inflammation in the gastrointestinal tract. The heterogeneity of IBD is...
