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Exploring the Targets and Molecular Mechanisms of Curcumin for the Treatment of Bladder Cancer Based on Network Pharmacology, Molecular Docking and Molecular Dynamics
Curcumin, a phenolic compound derived from turmeric, has demonstrated anti-tumor properties in preclinical models of various cancers. However, the...
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Molecular targets of histone deacetylase inhibitors in neurodegeneration and neuroprotection
BackgroundNeurodegenerative diseases show various phenotypes of molecular and cellular malfunction including mitochondrial dysfunction and...
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Multifaceted Molecular Targets of Anti-Inflammatory Agents from Ayurvedic Plants
The relationship between prolonged inflammation and the occurrence of different fatal diseases like cancer was first identified in the nineteenth...
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Molecular docking as a tool for the discovery of molecular targets of nutraceuticals in diseases management
Molecular docking is a computational technique that predicts the binding affinity of ligands to receptor proteins. Although it has potential uses in...
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Potential molecular targets and drugs for basement membranes-related intervertebral disk degeneration through bioinformatics analysis and molecular docking
BackgroundThrough bioinformatics analysis to identify the hub genes of Intervertebral disc degeneration (IVDD) associated with basement membranes...
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Molecular modeling and simulation approaches to characterize potential molecular targets for burdock inulin to instigate protection against autoimmune diseases
In the current study, we utilized molecular modeling and simulation approaches to define putative potential molecular targets for Burdock Inulin,...
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Molecular targets in bone cancer pain: a systematic review of inflammatory cytokines
Bone cancer pain (BCP) profoundly impacts patient’s quality of life, demanding more effective pain management strategies. The aim of this systematic...
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Cardiac cell senescence: molecular mechanisms, key proteins and therapeutic targets
Cardiac aging, particularly cardiac cell senescence, is a natural process that occurs as we age. Heart function gradually declines in old age,...
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Identifying molecular targets of Aspiletrein-derived steroidal saponins in lung cancer using network pharmacology and molecular docking-based assessments
Lung cancer is one of the leading cancers and causes of cancer-related deaths worldwide. Due to its high prevalence and mortality rate, its clinical...
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Molecular targets and therapeutic strategies for triple-negative breast cancer
Triple-negative breast cancer (TNBC) is known for its heterogeneous complexity and is often difficult to treat. TNBC lacks the expression of major...
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Promising Molecular Targets and Novel Therapeutic Approaches in Neuroblastoma
Purpose of ReviewThis article provides a brief and up-to-date overview of promising molecular targets and novel therapeutic approaches in...
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Non-coding RNAs as skin disease biomarkers, molecular signatures, and therapeutic targets
Non-coding RNAs (ncRNAs) are emerging as biomarkers, molecular signatures, and therapeutic tools and targets for diseases. In this review, we focus...
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Parathyroid carcinoma: molecular therapeutic targets
Parathyroid carcinoma (PC) is an extremely rare malignant tumor of the parathyroid glands, accounting for less than 1% of primary...
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Identification of molecular targets of Trigonelline for treating breast cancer through network pharmacology and bioinformatics-based prediction
Breast cancer, a highly prevalent and fatal cancer that affects the female population worldwide, stands as a significant health challenge. Despite...
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Mechanisms and molecular targets surrounding the potential therapeutic effects of psychedelics
Psychedelics, also known as classical hallucinogens, have been investigated for decades due to their potential therapeutic effects in the treatment...
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Androgen receptor and hyaluronan-mediated motility receptor as new molecular targets of baicalein: new molecular mechanisms for its anticancer properties
Natural compounds known as phytochemicals have served as valuable resources for the development of new anti-cancer drugs and treatment of...
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Integrated investigation and discovery of therapeutic targets for 3-hydroxybakuchiol against diabetes based on molecular docking studies and cell experiments
BackgroundDiabetes mellitus is a prevalent endocrine condition. We aimed to investigate the anti-diabetic effects of 3-hydroxybakuchiol (HYD) by...
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Bladder Cancer Prevention: Potential Molecular Targets and Their Clinically Relevant Agents
Purpose of ReviewThis review summarizes the druggable targets within the critical signaling pathways and the promising clinically relevant drugs...
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Therapeutic Molecular Targets of Cancer and Animal Models: Adequacy and Drawbacks
Cancer has become a serious public health problem worldwide. The selection of applicable experimental animal models is essential for the transfer of...
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Integrating network pharmacology, bioinformatics, and experimental validation to unveil the molecular targets and mechanisms of galangin for treating hepatocellular carcinoma
BackgroundGalangin, a flavonoid compound, is derived from Alpinia officinarum Hance. Previous studies have shown that galangin can inhibit the...
