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Pathophysiology of Microvascular Disease in Diabetes
Diabetes and its associated complications place an enormous economic burden on public health systems, globally, highlighting the need for early...
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Assessment of Flap Perfusion: Microvascular Flowmetry
Flap failure is a rare but catastrophic outcome following free tissue transfer. Clinical assessment remains the gold standard technique for...
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Ocular microvascular alteration in patients with myocardial infarction—a new OCTA study
Myocardial infarction is defined as a sudden decrease or interruption in blood flow to the coronary arteries, causing ischemic necrosis of the...
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Purpura and Microvascular Occlusion
Purpuric lesions can be induced by thrombocytopenia, thrombocytosis, and platelet defects, or can be a manifestation of pigmented purpuric...
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MAP4K4 exacerbates cardiac microvascular injury in diabetes by facilitating S-nitrosylation modification of Drp1
Dynamin-related protein 1 (Drp1) is a crucial regulator of mitochondrial dynamics, the overactivation of which can lead to cardiovascular disease....
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Percutaneous radiofrequency thermocoagulation and microvascular decompression for treating glossopharyngeal neuralgia: a retrospective clinical study
ObjectivesThis study aimed to investigate the differences in the effectiveness of percutaneous radiofrequency thermocoagulation (PRT) and...
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Endothelial MICU1 alleviates diabetic cardiomyopathy by attenuating nitrative stress-mediated cardiac microvascular injury
BackgroundMyocardial microvascular injury is the key event in early diabetic heart disease. The injury of myocardial microvascular endothelial cells...
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Technology for the formation of engineered microvascular network models and their biomedical applications
Tissue engineering and regenerative medicine have made great progress in recent decades, as the fields of bioengineering, materials science, and stem...
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Endothelial ILK induces cardioprotection by preventing coronary microvascular dysfunction and endothelial-to-mesenchymal transition
Endothelial dysfunction is an early event in coronary microvascular disease. Integrin-linked kinase (ILK) prevents endothelial nitric oxide synthase...
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Generation and characterisation of scalable and stable human pluripotent stem cell-derived microvascular-like endothelial cells for cardiac applications
Coronary microvascular disease (CMD) and its progression towards major adverse coronary events pose a significant health challenge. Accurate in vitro...
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Soluble pathogenic tau enters brain vascular endothelial cells and drives cellular senescence and brain microvascular dysfunction in a mouse model of tauopathy
Vascular mechanisms of Alzheimer’s disease (AD) may constitute a therapeutically addressable biological pathway underlying dementia. We previously...
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Accelerated Extracellular Nucleotide Metabolism in Brain Microvascular Endothelial Cells in Experimental Hypercholesterolemia
Hypercholesterolemia affects the neurovascular unit, including the cerebral blood vessel endothelium. Operation of this system, especially in the...
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Phenotype-based management of coronary microvascular dysfunction
40-70% of patients undergoing invasive coronary angiography with signs and symptoms of ischemia are found to have no obstructive coronary artery...
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Human blood vessel organoids reveal a critical role for CTGF in maintaining microvascular integrity
The microvasculature plays a key role in tissue perfusion and exchange of gases and metabolites. In this study we use human blood vessel organoids...
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Microvascular decompression for hemifacial spasm after Bell’s palsy: a retrospective clinical study
ObjectiveThis study aimed to investigate the clinical characteristics of hemifacial spasm (HFS) after Bell’s palsy and to evaluate the therapeutic...
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Empagliflozin attenuates cardiac microvascular ischemia/reperfusion injury through improving mitochondrial homeostasis
BackgroundEmpagliflozin has been reported to protect endothelial cell function, regardless of diabetes status. However, the role of empagliflozin in...
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Pathology and prevention of brain microvascular and neuronal dysfunction induced by a high-fructose diet in rats
A high-fructose diet causes metabolic abnormalities in rats, and the cluster of complications points to microvascular and neuronal disorders of the...
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Use superb microvascular imaging to diagnose and predict metastatic cervical lymph nodes in patients with papillary thyroid carcinoma
PurposePapillary thyroid carcinoma (PTC) with metastatic lymph nodes (LNs) is closely associated with disease recurrence. This study accessed the...
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Investigating the Function of MicroRNAs in Human Retinal Microvascular Endothelial Cells of Diabetic Retinopathy
Diabetic retinopathy (DR) is the main complication of diabetes mellitus (DM). Recent studies have implicated microRNAs dysfunction in human retinal...
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Insight into microvascular adaptive alterations in the Glisson system of biliary atresia after Kasai portoenterostomy using X-ray phase-contrast CT
ObjectivesTo investigate microvascular alterations in the Glisson system of biliary atresia (BA) patients after Kasai portoenterostomy (KP) using...
